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Synthesis, spectral analysis and antimicrobial activity of 2(1H)-quinolinone tethered 1,3,5-triazine derivatives

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Savaniya N. P., Khakhariya A. D., Pankhaniya P. P., Ladva K. D.
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vol. 55
25-32
EN
A series of novel quinolinone containing 1,3,5-triazine derivatives have been synthesized, characterized and screened for antimicrobial activity. 7-((4-((3-fluoro-4-morpholinophenyl)amino)-6-(arylamino)-1,3,5-triazin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one derivatives were prepared by condensation of 7-((4-chloro-6-((3-fluoro-4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one with differently substituted aniline derivatives. The designed compounds were confirmed via IR, 1H NMR, Mass spectral data. The synthesized compounds checked for their antimicrobial activity using gram-positive bacteria, gram-negative bacteria and fungi against standard drugs.
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