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New analogue of cyclolinopeptide B modified by amphiphilic residue of α-hydroxymethylmethionine.

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Witkowska R., Donigiewicz A., Zimecki M., Zabrocki J.
Acta Biochimica Polonica
|
2004
|
vol. 51
|
issue 1
67-72
EN
In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-a-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.
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