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Contactless Electroreflectance Study of Temperature Dependence of Fundamental Band Gap of ZnSe

100%

Krystek W., Malikova L., Pollak F. H., Tamargo M. C., Dai N., Zeng L., Cavus A.

Acta Physica Polonica A

1995

vol. 88

issue 5

1013-1017

We report a systematic study of the temperature variation of the energy [E_{0}(T)] and broadening parameter [Γ_{0}(T)] of the fundamental band gap of ZnSe in the range 27 K < T < 370 K using contactless electroreflectance. The obtained values of E_{0}(T) and Γ_{0}(T) have been fit to various semi-empirical expressions to obtain information about the exciton-phonon coupling in this system. The experimentally determined E_{0}(T) also is of significance for technological applications since it can be used to determine the operating temperature of ZnSe-based devices such as quantum well lasers.

Immunomodulatory effects of HMG-CoA reductase inhibitors

100%

Danesh F. R., Anel R. L., Zeng L., Lomasney L., Sahai A., Kanwar Y. S.

3-Hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins are competitive inhibitors of the rate limiting enzyme in cholesterol synthesis. Several clinical trials have shown a marked reduction in cholesterol levels associated with decreased cardiovascular mortality in patients treated with statins. However, more recent observations have suggested that the clinical benefits of statins may be, at least in part, independent of the effect of statins on cholesterol synthesis. These so-called pleiotropic or cholesterol-independent effects of statins could be the result of reduction in the formation of intermediaries in the mevalonate pathway as statins by inhibiting L-mevalonic acid synthesis also prevent the production of isoprenoids in the cholesterol biosynthetic pathway. Isoprenoids serve as important lipid attachments for the posttranslational modification of a variety of proteins such as small GTP-binding proteins of the Ras superfamily implicated in intracellular signaling. The list of different pleitropic effects of statins is still growing and include among others direct effects of statins on modulating endothelial function, decreasing oxidative stress, and more recently anti-inflammatory and immunomodulatory actions of statins. For instance, statins decrease T cell activation, the recruitment of inflammatory cells into atherosclerotic lesions, and inhibit IFN-gamma expression of MHCII on antigen-presenting cells. This review article summarizes the anti-inflammatory and immunomodulatory effects of statins and thus provides a new rationale to use statins as a new class of immunosuppressive agents.

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1 Acta Physica Polonica A

1 Archivum Immunologiae et Therapiae Experimentalis

1 2003

1 1995

2 Zeng L.

1 Anel R. L.

1 Cavus A.

1 Dai N.

1 Danesh F. R.

1 Kanwar Y. S.

1 Krystek W.

1 Lomasney L.

1 Malikova L.

1 Pollak F. H.

1 Sahai A.

1 Tamargo M. C.

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Contactless Electroreflectance Study of Temperature Dependence of Fundamental Band Gap of ZnSe

Immunomodulatory effects of HMG-CoA reductase inhibitors