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1

Structure and function of RNA elements present in enteroviral genomes

100%

Dutkiewicz M., Stachowiak A., Swiatkowska A., Ciesiołka J.

Acta Biochimica Polonica

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2016

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vol. 63

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issue 4

623-630

EN

Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in the host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.

2

Probing the anticodon loop structue in yest tRNA^Phe_-Y with single strand-specific nuclease S_1

100%

Marciniec T., Ciesiołka J., Krzyżosiak W.

Acta Biochimica Polonica

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1989

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vol. 36

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issue 2

123-130

3

The role of the 5' terminal region of p53 mRNA in the p53 gene expression

100%

Swiatkowska A., Zydowicz P., Sroka J., Ciesiołka J.

Acta Biochimica Polonica

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2016

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vol. 63

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issue 4

645-651

EN

The p53 tumour suppressor protein is one of the major factors responsible for cell cycle regulation and protection against cancer development. This is why it is often referred to as "the guardian of the genome". On the other hand, mutations in the p53 gene are connected with more than 50% of tumours of various types. The thirty-six years of extensive research on the p53 gene and its protein products have shown how sophisticated the p53-based cell system control is. An additional level of complexity of the p53 research is connected with at least twelve p53 isoforms which have been identified in the cell. Importantly, disturbance of the p53 isoforms' expression seems to play a key role in tumorigenesis, cell differentiation and cell response to pathogenic bacteria, and RNA and DNA viruses. Expression of various p53 isoforms results from the usage of different transcription promoters, alternative splicing events and translation initiation from alternative AUG codons. The importance of the 5'-terminal regions of different p53 mRNA transcripts in the multi-level regulation of the p53 gene has recently been documented. In this review we focus on the structural features of these regions and their specific role in the p53 translation initiation process.

4

The response of the double strand-specific nuclease V_1 to Y-base removal in yeast tRNA^Phe

100%

Marciniec T., Ciesiołka J., Krzyżosiak W.

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5

Specificity and mechanism of the cleavages induced in yeast tRNA^Phe by magnesium ions

88%

Marciniec T., Ciesiołka J., Wrzesiński J., Wiewiórowski M., Krzyżosiak W. J.

Acta Biochimica Polonica

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1989

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vol. 36

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issue 3-4

183-194

6

Ribozymes of the hepatitis delta virus: Recent findings on their structure, mechanism of catalysis and possible applications.

88%

Ciesiołka J., Wrzesinski J., Łęgiewicz M., Smólska B., Dutkiewicz M.

Acta Biochimica Polonica

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2001

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vol. 48

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issue 2

409-418

EN

Although the delta ribozymes have been studied for more than ten years the most important information concerning their structure and mechanism of catalysis were only obtained very recently. The crystal structure of the genomic delta ribozyme turns out to be an excellent example of the extraordinary properties of RNA molecules to fold into uniquely compact structures. Details of the X-ray structure have greatly stimulated further studies on the folding of the ribozymes into functionally active molecules as well as on the mechanism of RNA catalysis. The ability of the delta ribozymes to carry out general acid-base catalysis by nucleotide side chains has been assumed in two proposed mechanisms of self-cleavage. Recently, considerable progress has been also made in characterizing the catalytic properties of trans-acting ribozyme variants that are potentially attractive tools in the strategy of directed RNA degradation.

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1 Łęgiewicz M.

Structure and function of RNA elements present in enteroviral genomes

Probing the anticodon loop structue in yest tRNA^Phe_-Y with single strand-specific nuclease S_1

The role of the 5' terminal region of p53 mRNA in the p53 gene expression

The response of the double strand-specific nuclease V_1 to Y-base removal in yeast tRNA^Phe

Specificity and mechanism of the cleavages induced in yeast tRNA^Phe by magnesium ions

Ribozymes of the hepatitis delta virus: Recent findings on their structure, mechanism of catalysis and possible applications.