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1

The modulatory effect of aminothiols on the clastogenic activity of X-rays assayed by the in vivo mouse micronucleus test

100%
Mazur L.
Folia Biologica
|
1996
|
vol. 44
55-59
EN
The modulatory effect of AET (S-2-aminoethylisothio-uronium bromide hydrobromide) and WR-2721 (S-2-/3-ami- nopropylamino/ethylphosphorothioic acid) on the clastogenic activity of X-rays was assessed by the in vivo mouse micronucleus test. The frequency of micronucleated polychromatic erythrocytes (MNPCEs) in the peripheral blood of adult male Swiss mice exposed to 5 Gy X-rays alone, or treated with AET or WR-2721, at a dose of 200 mg/kg body weight, 15 or 30 minutes prior to X-irradiation, respectively, was determined during a fifteen-day period. The number of micronuclei increased on day 1 post-irradiation in X-irradiated mice and declined thereafter with the frequency of MNPCEs remaining lower in the thiol pre-treated mice. A more effective protection against the clastogenic activity of X-rays in the erythropoietic system was observed after WR-2721 administration than AET application.
2

Frequency of micronuclei in mouse peropheral erythrocytes following WR -2721 application and X-irradiation

100%
Mazur L.
Folia Biologica
|
1995
|
vol. 43
|
issue 3-4
111-114
EN
The grequency of micronucleated polychromatic erythrocytes (MNPCEs) in the mouse peripheral bloos was assessed after WR-2721 (S-2-/3-aminopropylamino/ethylphosphorothioic acid) application and X-irradiation.The genotoxic was demonstratred for X-rays and WR-2721, as well as a protective effect of the thiol drug against X-ray-induced genotoxicity in the erythropoietic system.After X-irradiation of the mice, the number of MNPCEs was distincly increased.WR-2721 administration prior to X-irradiation resulted in a reduction of the X-ray- induced rise in the frequency of micronuclei.WR-2721 given alone, without subsequent X-irradiation, increased the number of MNPCES.The genotoxic and radioprotective effect of WR-2721 depended on the dose applied and the time interval between the thiol agent treatment and exposure of the mice to X-rays.
3

Induction of DNA breakage in U937 cells by oxazaphosphorines

45%
Mazur L., Opydo-Chanek M., Stojak M., Baran J., Niemeyer U.
Folia Biologica
|
2010
|
vol. 58
|
issue 1-2
15-20
EN
Oxazaphosphorines are a class of DNA alkylating agents. The aim of the present study was to compare the possible influence of three new generation oxazaphosphorines, D-17272 (mafosfamide cyclohexylamine salt), D-18864 (4-hydro-peroxy-cyclophosphamide), and D-19575 (glufosfamide, beta-D-glucose-isophosphoramide mustard) on DNA damage induction in the human histiocytic lymphoma U937 cells. The flow cytometry APO-BRDUTM assay, based on the TUNEL method, was used for the in situ detection of DNA strand breaks. After exposure of U937 cells to the oxazaphosphorines, the patterns of temporary changes in the frequency of TUNEL positive U937 cells, expressing DNA breakage, were determined. The effects of the oxazaphosphorines on U937 cells were dependent on the agent tested and its dose, and the time intervals after the drug application. The different potential of D-17272, D-18864 and D-19575 to induce DNA strand breakage in the human histiocytic lymphoma U937 cells was shown.
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