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  1. 1 Open Chemistry

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  1. 1 2004

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  1. 1 Czuchajowski L.

  2. 1 Gajewski M.

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Phosphorus (V) porphyrin diaxially substituted with Leu-enkephalin

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Gajewski M., Czuchajowski L.
Open Chemistry
|
2004
|
vol. 2
|
issue 3
446-455
EN
Synthesis of the first phosphorus (V) porphyrin-peptide conjugate was successfully accomplished. A biologically active peptide, leucine enkephalin, was constructed on the phosphorus atom of the 5,10,15,20-meso-tetraphenylporphinato dichlorophosphorus (V) chloride. The method involved solution phase peptide synthesis. The first C-terminal amino acid in the sequence of the peptide was axially attached to the porphyrin through a linker, 3-aminopropanol, and the remainder of leucine enkephalin was synthesized by subsequent additions of amino acids. Leucine enkephalin-P(V) porphyrin conjugate represents a new group of compounds, and its synthesis broadens potential applications of P(V) porphyrine, e.g. in photodynamic therapy.
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