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Introduction: Desmoid tumors are rare and locally aggressive neoplasms originating from fibroblasts, characterized by a variable and often unpredictable clinical course. Case report: We present the case of a 43-year-old man with a neck lump who was diagnosed with a desmoid tumor of the left periverterbal space adjacent to the C5 and C6 roots of the brachial plexus. Conclusions: Treatment of desmoid tumors is challenging. Each case should be approached individually, and the course of action depends on the location and symptomatology of the tumor. Available management options include: active surveillance, systemic treatment (chemotherapy, hormone therapy and molecular drugs), radiotherapy and surgery.
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