The applications of chitin are limited due to its insolubility in most organic solvents. The chemical modification of chitin to generate new bio-functional materials can bring more desirable properties. A concentration of 5% can be obtained. We have successfully prepared chitin fibres and spheres by dissolving chitin in 85% phosphoric acid in various coagulating agents and then regenerating it in 10% sodium hydroxide. The change in molecular structure was studied by Fourier Transform Infrared Spectroscopy (FTIR). The surface morphology of different biomaterials was observed using scanning electron microscopy (SEM) and optical microscopy (OM).
In this study, a solution of dibutyrylchitin (DBC)/polylactide (PLA) blend micro and nanofibres were successfully fabricated using blends of 2,2,2-trifluoroethanol (TFE) as solvents. Fibres were produced from the solutions by electrospinning. The DBC/PLA blend solutions in various ratios were studied for electrospinning into micro/nanofibres. The morphology of the micro and nanofibres was observed by scanning electron microscope (SEM). The biggest diameters of DBC/PLA fibres were obtained for the blended microfibres in ratios of 10/90 and 25/75. The smallest diameter was observed for pure polymers. The antibacterial properties were examined for materials obtained by electrospinning. In the experiments, materials with antibacterial properties were made. It is likely that the electrospun micro and nanofibres will be used in the native extracellular matrix for tissue engineering.
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