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Blue toe syndrome as the initial manifestation of ANCA-associated vasculitis

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Marinchev L., Hristova M., Baleva M., Kolarov Z.

Open Medicine

2013

vol. 8

issue 5

577-579

The blue (or purple) toe syndrome describes the development of a blue or violaceous discoloration in one or more toes in the absence of obvious trauma, serious cold-induced injury or disorders producing generalized cyanosis. The presence of blue toe syndrome requires the clinician to search for primary systemic vasculitides, as well as for malignancy, underlying infection, thrombosis, cardiovascular pathology and other diseases. An accurate diagnosis is critical because many of the causes threaten life or limb, but the patient’s medical history, accompanying non-dermatologic findings on physical examination and the use of discriminatory laboratory tests are usually more important than the nature of the cutaneous abnormalities. We describe the case of a 53-year-old Caucasian male patient presenting with blue toe syndrome as the initial manifestation of ANCA-associated vasculitis.

Diagnostic significance of anti-annexin-A5 antibody determination

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Baleva M., Hristova M., Nikolov K.

Open Medicine

2010

vol. 5

issue 1

6-11

Anti-annexin A5 antibodies are directed against annexin A5 - a phospholipid-binding protein that belongs to the ubiquitous annexin family. These antibodies were first discovered in 1994 by Matsuda et al. in women with recurrent fetal loss or preeclampsia and in patients with systemic lupus erythematosus and positive lupus anticoagulant and/or anticardiolipin antibodies. Since then anti-annexin A5 antibodies have been the focus of research. In addition to their well known prothrombotic and procoagulant activities the authors discuss the involvement of these antibodies in the pathogenesis of antiphospholipid syndrome, recurrent pregnancy loss, systemic lupus erythematosus and other immune and non-immune disorders. Controversial reports are presented and a possible interpretation of the results is given. The authors suggest the significance of anti-annexin A5 antibodies as an additional diagnostic marker and discuss the necessity of more extensive research on their clinical significance.

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2 Open Medicine

1 2013

1 2010

2 Baleva M.

2 Hristova M.

1 Kolarov Z.

1 Marinchev L.

1 Nikolov K.

Search results

Blue toe syndrome as the initial manifestation of ANCA-associated vasculitis

Diagnostic significance of anti-annexin-A5 antibody determination