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Specific inhibitors of the

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Mirowski M., Wierzbicki R.
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vol. 47
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issue 2
147-157
EN
The article contains a survay of the recent papers on the which regulate the process of - PAI-1 and PAI-2. Both of them belong to serine family and are specific for tPA as well as uPA, forming stable complexes in molar ratio 1 : 1 with them. PAI-1, secreted mainly by and , is the main plasmic inhibitor of plasminogen activation. PAI-2, originated essentially from , appears in during .
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