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CANNABINOIDS AS ANTIEMETICS: A SHORT REVIEW

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Mikołajczak P. Ł., Calavia Liano H., Zakowicz P.
Acta Poloniae Pharmaceutica - Drug Research
|
2018
|
vol. 75
|
issue 5
1063-1068
EN
Chemotherapy Induced Nausea and Vomiting (CINV) remains one of the most frequent adverse effects of cancer chemotherapy, often leading to patient non-adherence to the prescribed chemotherapeutic regime, as well as several associated complications. Current antiemetic therapy has been reported to provide relief of CINV in 75%-80% of patients, still leaving margin for improvement. This makes the development and study of novel antiemetics, especially those providing relief of both early and late phases of CINV, a matter of prime importance. The purpose of this review is to illustrate the mechanism of action of cannabinoid substances and provide a general view into their current use as antiemetic drugs in clinical practice. Several research articles pertaining the subject were compiled and studied. This review presents the information thereby obtained. It is concluded that cannabinoids possess value as antiemetic drugs, along with certain properties that set them apart from other classes of antiemetic substances.
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