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Influence of Total Thyroidectomy on Orbital Opthalmopathy and Levels of Antithyroid Antibodies in Patients with Graves' Disease

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Domosławski P., Łukieńczuk T., Forkasiewicz Z., Balcerzak W., Bednarz W., Dawiskiba J., Krawczyk Z., Wojtczak B., Olewiński R., Podhorska-Okołów M.

Polish Journal of Surgery

2007

vol. 79

issue 3

167-172

Graves' disease is an autoimmune disease. One of the most severe complications of Graves' disease is orbitopathy.The aim of the study was to estimate the influence of total thyroidectomy on the postoperative course of exophthalmus and determine the levels of thyroid antibodies after surgery.Material and methods. During the period between 2002 and 2005, 1514 strumectomies were performed at the I Chair and Department of General, Gastroenterological and Endocrine Surgery, Medical University in Wroclaw. The study included 69 (4.5%) patients, who were operated on because of Graves' disease. Forty-two (60%) of these patients had progressive opthalmopathy and were subjected to total thyroidectomy (35 women and 7 men, mean age was 31 years). The diagnosis of Graves' disease was established on the basis of the clinical evaluation, fT3, fT4 and TSH values, as well as the determination of serum thyroid antibody levels. Every patient was subjected to an opthalmological examination, with measurements of the degree of exopthalmus, as compared to the ATA (American Thyroid Association) scale. Above-mentioned parameters were measured before surgery and 6, 12 and 18 months after total thyroidectomy.Results. Considering patients after total thyroidectomy, exophthalmus did not proceed. In 17 (40%) patients, 2- 3 mm of eyeball retraction was noted, mainly during the initial six months. After surgery, a statistically significant reduction of TSH-receptor and anti-TPO antibody values were observed.Conclusions. Total thyroidectomy in patients with Graves' disease and orbital opthalmopathy significantly reduced the progression of orbitopathy. It also leads to the normalization of serum anti-recepor (TRAb) and anti-peroxidase (anti-TPO) antibody levels.Total thyroidectomy is a quick and effective procedure in the hands of an experienced surgeon and should be performed in secondary or tertiary care centers.

Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose

100%

Fraczyk J., Walczak M., Balcerzak W., Pokajewicz K., Wieczorek P., Młynarski W., Fendler W., Kaminski Z. J.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 4

1017-1029

A novel diagnostic method based on recognition of qualitative and quantitative composition of healthy and tumor tissue samples by library of molecular receptors was presented. Molecular receptors were formed by self-organization of N-lipidated peptides attached in the regular fashion via aminophenylamino-1,3,5-triazine linker to the surface of cellulose plate. For samples testing, the library was cloned into multiple, identical copies and for each experiment the new clone was used. The binding process was monitored by staining the discs with Brilliant Black and quantitative color measurement was performed in 256 grade gray scale. Substantial differences in the composition of healthy and tumor samples were observed in most cases. The highly individual chemical fingerprints were found to be reliant on the cancer type. For malignant papillary thyroid cancer statistical analysis identified two receptors most useful for diagnostic purposes.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 Polish Journal of Surgery

1 2018

1 2007

2 Balcerzak W.

1 Bednarz W.

1 Dawiskiba J.

1 Domosławski P.

1 Fendler W.

1 Forkasiewicz Z.

1 Fraczyk J.

1 Kaminski Z. J.

1 Krawczyk Z.

1 Młynarski W.

1 Olewiński R.

1 Podhorska-Okołów M.

1 Pokajewicz K.

1 Walczak M.

1 Wieczorek P.

1 Wojtczak B.

1 Łukieńczuk T.

Search results

Influence of Total Thyroidectomy on Orbital Opthalmopathy and Levels of Antithyroid Antibodies in Patients with Graves' Disease

Molecular Fingerprints of Thyroid Cancer Cells by Using Library of Molecular Receptors Formed by N-Lipidated Peptides Immobilized on Cellulose