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In Vitro Evaluation of Alpha-Glucosidase and Alpha-Amylase Inhibitory Activity of Copper(II) Complex of King of Bitters Crude Extract

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Oladipo M. A., Ojo A. O., Ishola K. T., Adepoju A. J.
World News of Natural Sciences
|
2023
|
vol. 49
38-50
EN
Diabetes mellitus is a chronic disorder which characterized by high concentration of blood glucose. It is known as one of the major deadly diseases that require a serious attention. Many conventional drugs which have been employing in treating the disease are reported to less effective, expensive and some are not locally available. Therefore, in order to search for more effective, inexpensive and locally available drug, this study investigated antidiabetic activity of Cu(II) complex of King of bitters leaves crude extract. The crude extract of the plant was obtained in n-hexane. The metal complex of the crude extract was synthesized and characterized using solubility tests, Infrared and Ultraviolet-Visible spectroscopic analyses. The antidiabetic activities of the crude extract and its metal complex were examined against α-amylase and α-glucosidase enzymes while acarbose drug was employed as a standard drug. The metal complex showed different degrees of solubility in different solvents. Infrared analysis suggested coordination of the crude extract to the metal ion through oxygen donor atom while the formation of the complex was affirmed through the occurrence of d-d transitions in the visible region of the metal complex. The crude extract and its metal complex displayed good activities against α-amylase and α-glucosidase enzymes. It is suggested that the compounds are promising candidates to inhibit α-amylase and α-glucosidase.
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