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Nephroprotective role of Potentilla reptans L. aqueous extract on paracetamol - induced kidney nephrotoxicity in male mice

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Muthulingam M., Prabhahar C., Senthilmurugan S., Pugazhendy K., Vijayan P., Baranitharan M.
World News of Natural Sciences
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2021
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vol. 39
76-85
EN
Nephroprotective effects (NPE) of simple Potentilla reptans - aqueous leaf extract (Pr-ALE) leaves on Paracetamol induced kidney poisonousness in wistar rats. Adult male wistar rats (weight range (WR): 200-220g) were divided into 6 groups (n=6). Paracetamol (PA) and Silymarin (SY) stayed managed intraperitoneally arranged the 5th day to rats in all groups but the normal control. Furthermore, a significant nephroprotective (NP) of the aqueous leaf extract (ALE) and oral dose of PA and SY. Pr-ALE did not mortality or significant changes in the body weight. Progression of nephrotoxicity (NT) induced by PA in rats was interfered by Pr-ALE managed, and these effects were correspond to those managed with SY. This is the first record on NPE of Pr against PA-induced NT.
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Entomotoxicity properties of eco-friendly methanol extract fractions from Phyla nodiflora (L.) Greene leaf exhibits mosquito larvicidal, pupicidal and antimicrobial activity

100%
Irrusappan H., Gokulakrishnan J., Elumalai K., Senthilmurugan S., Vijayan P., Baranitharan M.
World News of Natural Sciences
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2022
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vol. 42
107-122
EN
Mosquitocidal activity of Phyla nodiflora methanol leaf extract fractions (Pn-MLEFr) was controlled and using main components on malarial vector, Anopheles stephensi (An. stephensi). Pn-MLE were characterized utilizing tools containing TLC, CC, FTIR and GCMS, and it against 3rd instars larvae of An. stephensi, followed by pupicidal activity was determined to concentration of 1, 3, 5 ppm. In phytochemical, characterized by GCMS analysis was carried out to be eligible for the constituents of the MLE. Pn-MLE Fr-6 showed the highest LC50 and LC90 values of 25.80 and 68.45 ppm, respectively. Fr-6 was found to be most effective for this activity provided pupa stage at death and stage of non-mortality values were 22.85 (NDP), 76.1 (TDP), 1.2 (DP), 0.7 (DA), 78% (TM%) and 6.6 (NAE), 22 (AE%) at 1 ppm against An. stephensi. Moreover, 3 and 5 ppm were provided TM% and AE% values of 94.43% and 5.57%; 100% and no adults emerged. In GC-MS analyzes, a total of 21 compounds were identified in the Pn-MLE, the main component was Ergosta-5,22-dien-3-ol, acetate, (3á,22E)-. Further, the AgNPs synthesized using Fm-ALE showed enhanced anti-bacterial activity. The reports revealed the Ergosta-5,22-dien-3-ol, acetate, (3á,22E)- was the most one of the important a compound provides malarial vector control from Pn-MLEFr.
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