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CD30-positive T-cell lymphoproliferation of the bulbar conjuntival mucosa showing spontaneous remission

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Paula M. Á., Garrido Ceca G., Guijarro Rojas M.
OphthaTherapy
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2021
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vol. 8
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issue 1
45-48
EN
Introduction: CD30-positive T-cell lymphoproliferative lesions represent a spectrum of heterogeneous disorders. Clinical case: An incision biopsy was performed in a 25-year-old man with a lump in the bulbar conjunctiva. Immunohistochemistry indicated membrane positivity for CD3 and CD30 in over 75%. PCR identified the monoclonal nature of the T-cells. The hematological study was normal. Following biopsy, the conjunctival tumor diminished until disappear. Conclusions: Mucosal CD30-positive T-cell lymphoproliferation could be ascribed to a reactive process but it is necessary to rule out a primary conjunctival tumor or the first manifestation of an anaplastic large cell lymphoma.
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An unusual presentation of corneal intraepithelial neoplasia

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Marticorena-Álvarez P., Garrido Ceca G., Celdrán Vivancos D. A.
OphthaTherapy
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2020
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vol. 7
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issue 4
302-304
EN
Introduction: Conjunctival/corneal intraepithelial neoplasms are premalignant lesions usually showing conjunctival or limbal involvement. We report the rare case of an isolated corneal intraepithelial lesion. Clinical case: An 80-year-old woman with an elevated, avascular, well-demarcated grey corneal plaque. After epitheliectomy and alcohol, the excised lesion was identified as a high-grade epithelial neoplasia. Treatment was topical interferon α-2b for 1 month without recurrences. Conclusions: A well-defined greyish corneal opacity should always raise suspicion of an intraepithelial neoplasia. In the present case, epitheliectomy and topical recombinant interferon proved successful.
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