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In vitro cytostatic activity of some amino acid 4-N-substituted cytosines

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Hladon B., Sloderbach A., Radosh P., Spychala J., Golankiewicz K.
Archivum Immunologiae et Therapiae Experimentalis
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1992
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vol. 40
|
issue 2
145-150
EN
Cytotoxicity of 22 amino acid 4-N-substitued cytosine derivatives was studied on KB and HeLa human tissue cultures. The secondary modification of tryptamine substituent seems to be a determining factor of the cytotoxic activity of 4-N-pyrimidinyl amino acids. The activity of the investigated compounds was inversely dependent on their solubility limited by the results of the solubility-activity relationship analysis.
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