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Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies

100%

Gondek S., Ogledzinski M., Lin W., Milejczyk K., Juengel B., Potter L., Bachul P. J., Basto L., Perea L., Wang L.-J., Tibudan M., Witkowska Z., Barth R., Fung J., Witkowski P.

European Journal of Translational and Clinical Medicine

2023

vol. 6

issue 1

9-13

Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.

En bloc liver and pancreas transplantation after total pancreatectomy with autologous islet transplantation

88%

Generette G. S., Bachul P. J., Golab K., Basto L., Pyda J. S., Borek P., Tibudan M., Anteby R., Perea L., Charlton M., Perez-Gutierrez A., Jayant K., Lucander A., Matthews J. B., Millis J. M., Fung J., Witkowski P.

European Journal of Translational and Clinical Medicine

2020

vol. 3

issue 2

11-17

We present a patient with intractable and debilitating pain secondary to chronic pancreatitis who was effectively treated with total pancreatectomy with islet autotransplantation (TPIAT). Islets engrafted into his liver significantly contributed to improved blood glucose control and quality of life. Subsequently, the patient developed alcohol related acute liver failure and en bloc liver and pancreas transplantation was performed to replace the failing liver with engrafted islets. Pancreas transplantation was required to resolve his life-threatening severe hypoglycemic episodes. Herein, we detail an innovative and multidisciplinary management of this complex medical problem.

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2 European Journal of Translational and Clinical Medicine

1 2023

1 2020

2 Bachul P. J.

2 Basto L.

2 Fung J.

2 Perea L.

2 Tibudan M.

2 Witkowski P.

1 Anteby R.

1 Barth R.

1 Borek P.

1 Charlton M.

1 Generette G. S.

1 Golab K.

1 Gondek S.

1 Jayant K.

1 Juengel B.

1 Lin W.

1 Lucander A.

1 Matthews J. B.

1 Milejczyk K.

1 Millis J. M.

1 Ogledzinski M.

1 Perez-Gutierrez A.

1 Potter L.

1 Pyda J. S.

1 Wang L.-J.

1 Witkowska Z.

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Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies

En bloc liver and pancreas transplantation after total pancreatectomy with autologous islet transplantation