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Flora i roślinność starych drzewostanów sosnowych w uroczysku Broników (Załęczański Park Krajobrazowy

100%

Janiak A., Łódzki U.

Acta Universitatis Lodziensis. Folia Botanica

2001

vol. 16

In this paper the geobotanical character of some parts of the Broników forest range is presented. The results of researches taken place during 1998 and 1999 are 36 taxons of lichens, 24 species of bryophytes and 77 species of vascular plants found on this area. The following plant communities were distinguished: Cladonio-Pinetum, Leucohryo-Pinetum, Molinio-Pinetum, Vaccinio uliginosi-Pineium. The location of distinguished communities was shown on a real vegetation map.

Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal activity.

45%

Janiak A., Cybulska B., Szlinder-Richter J., Borowski E., Milewski S.

vol. 49

issue 1

77-86

N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) and 2-amino-2-deoxy-D-glucitol-6-phosphate (ADGP) are strong inhibitors of the essential fungal enzyme, glucosamine-6-phosphate synthase, but their antifungal activity is poor, due to slow penetration of these agents through the cytoplasmic membrane. In the present studies we have exploited the possibility of enhancement of ADGP and FMDP antifungal activity by improving their transport properties. It has been found that membrane-permeabilising polyene macrolides amphotericin B (AMB) and its N-methyl-N-fructosyl methyl ester derivative (MF-AME), at subinhibitory concentrations, facilitate diffusion of ADGP through the fungal cell membrane, thus allowing a decrease of its minimal inhibitory concentration (MIC). Synergistic effects have been observed for combinations of ADGP with AMB or MF-AME. Fractional inhibitory concentration (FIC) indexes, determined against a number of Candida spp., have been in the 0.18-0.81 range. Weak antifungal synergistic effects have been found for combinations of FMDP with AMB or MF-AME. ADGP can be easily encapsulated into unilamellar lipid vesicles. Liposomal preparations of ADGP demonstrated stronger antifungal activity against some fungal strains than free ADGP.

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1 Acta Biochimica Polonica

1 Acta Universitatis Lodziensis. Folia Botanica

1 2002

1 2001

2 Janiak A.

1 Borowski E.

1 Cybulska B.

1 Milewski S.

1 Szlinder-Richter J.

1 Łódzki U.

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Flora i roślinność starych drzewostanów sosnowych w uroczysku Broników (Załęczański Park Krajobrazowy

Facilitated diffusion of glucosamine-6-phosphate synthase inhibitors enhances their antifungal activity.