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Is tumor expression of the major histocompatibility complex antigen required for T cell immune surveillance?

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Liu Y., Zheng P.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
|
vol. 49
|
issue 2 suppl.
61-64
EN
Tumor expression of major histocompatibility complex antigen (MHC) class I and class II is not essential for the induction of memory T cells. However, induction of MHC class I-restricted effector cytotoxic T cells (CTL) appears dependent on MHC class I expression on tumors. Moreover, the effector function of tumor-specific CTL requires direct recognition of the tumor. In contrast, both the inductive and the effector phases of MHC class II-restricted T cells are independent of MHC class II expression on tumors.
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