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Inclusion-dependent mechanism of modification of cyclodextrins with heterocycles

100%

Musiol R., Girek T.

Open Chemistry

2005

vol. 3

issue 4

742-746

Mono(6-deoxy-dimethylpyridinium)-β-cyclodextrins have been synthesized in reaction of mono (p-toluenesulfonyl) derivative of β cyclodextrin with the appropriate lutidine under microwave irradiation and conventional conditions. The results indicate that the mechanism consists of inclusion complex formation.

RP-HPLC determination of lipophilicity in series of quinoline derivatives

61%

Musiol R., Jampilek J., Podeszwa B., Finster J., Tabak D., Dohnal J., Polanski J.

Open Chemistry

2009

vol. 7

issue 3

586-597

In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds. [...]

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2 Open Chemistry

1 2009

1 2005

2 Musiol R.

1 Dohnal J.

1 Finster J.

1 Girek T.

1 Jampilek J.

1 Podeszwa B.

1 Polanski J.

1 Tabak D.

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Inclusion-dependent mechanism of modification of cyclodextrins with heterocycles

RP-HPLC determination of lipophilicity in series of quinoline derivatives