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  1. 1 Biotechnologia

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  1. 1 1996

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  1. 1 Rola J.

  2. 1 Zmudzinski J.

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Genome organization and function of BHV 1 protein

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Rola J., Zmudzinski J.
Biotechnologia
|
1996
|
issue 3
53-59
EN
Bivine herpervirus 1 (BHV 1) called also IBR/IPV virus is a member of the Herpersviridae family, Alphaherpersviridae subfsmily.The BHV 1 virus is an important pathogen of cattle, widely spread in the world.It is responsible for various diseases like infractious bovine rhinotracheitis (IBR), pustular vulvovaginitis (IPV), encephalitis, conjunctivitis, mastitis, enteritis and abortion.Four clinical forms of BHV 1 infections have been confirmed in Poland.THe paper summarized the research review on genome organization and function of the essential BHV 1 protein, BHV 1 genome is composed of a unique long segment UL anda unique short segment Us flanked by inverted repeats IRS and TRS.THe genome codes for 28-35 major envelope proteins among which gB, gC and gD play an important role in virus attachement and penetration into cells.Glycoprotein gD plays a crucial role in the stimulation of immune response and antibodies against gD, neutralizing virus infectivity.
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