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Dielectric and Electrooptic Investigations of B Phases οf Banana-Shaped Thioesters

100%

Wierzejska-Adamowicz M., Ossowska-Chruściel D., Chruściel J., Douali R., Legrand C., Marzec M., Mikułko A., Sikorska A., Wróbel S.

Acta Physica Polonica A

2010

vol. 117

issue 4

557-561

Electrooptic and dielectric measurements were done for B phases of two banana-shaped homologues 1,3-phenylene bis{4-[(4-nonylo-xy-benzoyl)sulfanyl]benzoate (9OSOR) and 1,3-phenylene bis{4-[(4-dodecylo-xy-benzoyl)sulfanyl]benzoate (12OSOR). Polarizing microscopy allowed to identify B_{1} phase for 9OSOR and B_{2} phase for 12OSOR on the basis of texture observation. Spontaneous polarization measurements were performed using reversal current method. The current response to applied triangular voltage shows that B_{1} phase is a ferroelectric and B_{2} phase - antiferroelectric one for which two well separated peaks were observed. Polarization for phase B_{1} of 9OSOR is rather small and its temperature dependence is unusual for ferroelectric liquid crystals - it increases with temperature. Spontaneous polarization for B_{2} phase of 12OSOR compound is of about 600 nC/cm^{2}. Dielectric spectra measured with bias field for B_{2} phase of 12OSOR show two well separated relaxation processes. In the low frequency range the relaxation process is connected with fluctuations of ferroelectric domains. The relaxation process in the high frequency range appearing also without bias field is connected with molecular reorientation. The dielectric spectra measured for B_{1} phase of 9OSOR with and without bias voltage showed only one dielectric relaxation process connected with molecular reorientation around the short axis.

Family with Li-Fraumeni syndrome and no evidence of a germline mutation of the p53 gene or chromosomal aberrations

72%

Sikorska A., Traczyk T. Z., Traczyk Z., Konopka K. L., Konopka L., Fiszer-Maliszewska F.-M. L., Fiszer-Maliszewska L., Wojciechowska W. B., Wojciechowska B., Pienkowska-Grela P.-G. B., Pienkowska-Grela B., Rygier R. J., Rygier J., Woroniecka W. R., Woroniecka R., Witkowska W. A., Witkowska A., Rusin R. M., Rusin M.

Journal of Applied Genetics

2001

vol. 42

issue 3

379-384

Li-Fraumeni syndrome is a rare autosomal, dominant trait of diverse types of cancers in children and young adults, with a predominance of soft tissue sarcomas, osteosarcomas, brain tumours, adrenocortical and breast carcinomas, as well as leukaemias. We present a family with an unusual cancer history fulfilling the criteria of Li-Fraumeni syndrome. Mutational analysis of the p53 gene in constitutional DNA of several affected members of the family did not show any germline p53 defect. Cytogenetic studies did not reveal any structural aberrations.

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1 Acta Physica Polonica A

1 Journal of Applied Genetics

1 2010

1 2001

2 Sikorska A.

1 Chruściel J.

1 Douali R.

1 Fiszer-Maliszewska F.-M. L.

1 Fiszer-Maliszewska L.

1 Konopka K. L.

1 Konopka L.

1 Legrand C.

1 Marzec M.

1 Mikułko A.

1 Ossowska-Chruściel D.

1 Pienkowska-Grela B.

1 Pienkowska-Grela P.-G. B.

1 Rusin M.

1 Rusin R. M.

1 Rygier J.

1 Rygier R. J.

1 Traczyk T. Z.

1 Traczyk Z.

1 Wierzejska-Adamowicz M.

1 Witkowska A.

1 Witkowska W. A.

1 Wojciechowska B.

1 Wojciechowska W. B.

1 Woroniecka R.

1 Woroniecka W. R.

1 Wróbel S.

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Dielectric and Electrooptic Investigations of B Phases οf Banana-Shaped Thioesters

Family with Li-Fraumeni syndrome and no evidence of a germline mutation of the p53 gene or chromosomal aberrations