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1

INVESTIGATION OF FENOFIBRATE DISSOLUTION RATE INCORPORATED ON SOLID DISPERSIONS INTO CHITOSAN

100%

Grimling B., Szcześniak M., Meler J., Pluta J.

Progress on Chemistry and Application of Chitin and its Derivatives

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2013

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vol. 18

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issue 18

149-156

EN

The aim of the study was to investigate the effect of chitosan on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in physical mixtures at the drug to polymer ratio of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 13 to 70 times) in fenofibrate solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of fenofibrate in the presence of chitosan at the weight ratio 1:9 increased with the increment of the molecular weight of the chitosan. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.

2

The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha-1 and beta-adrenoceptors in the rat cerebral cortex

100%

Nalepa I., Vetulani J.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 2

201-205

EN

Chronic co-administration of nifedipine and ECT or imipramine results in an increase in responsiveness of cerebral cortical alfa1-adrenoceptor as measured by accumulation of inositol phosphate in cortical slices after noradrenaline stimulation; the responsiveness of beta-adrenoceptor, measured by accumulation of cyclic AMP, was depressed similarly by antidepressant treatment with and without nifedipine.

3

PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

100%

Małolepsza-Jarmołowska K.

Progress on Chemistry and Application of Chitin and its Derivatives

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2022

|

vol. 27

175-182

EN

The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.

4

Disturbances in neurotransmission processes in aging and age-related diseases

100%

Ossowska K.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 2

109-131

EN

This paper reviews the changes in dopaminergic, cholinergic and glutamatergic neurotransmission, which occur in the aging of central nervous system CNS and in age-related diseases: Parkinson's disease (PD) and Alzheimer's disease (AD).

5

The effect of calcium channel blockade during electroconvulsive treatment on cerebral cortical adrenoceptor subpopulations in the rat

100%

Antkiewicz-Michaluk L., Michalik J., Romanska I., Vetulani J.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 2

197-200

EN

Chronic administration of nifedipine (5 mg/kg/day for 10 days) induced some biochemical effects consistent with those of antidepressants: a significant depression in cortical alfa2-adrenoceptor density and reduction of beta-adrenoceptor affinity; nifedipine co-administration with electroconvulsive treatment potentiated the beta-downregulatory effect of the latter.

6

Electroconvulsive shock-induced impairment of spatial learning is aggravated by nifedipine

100%

Popik P., Mamczarz J., Vetulani J.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 2

185-190

EN

Chronic electroconvulsive treatment applied immediately after a training session or with a 15 min delay impairs spatial learning and memory in the Morris water maze paradigm, and this impairment is not counteracted, but rather aggravated by co-administration of a calcium channel blocker, nifedipine.

7

PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

100%

Małolepsza-Jarmołowska K.

Progress on Chemistry and Application of Chitin and its Derivatives

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2018

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vol. 23

130 - 139

EN

The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.

8

Rennin inhibitors containinig statine and 6-aminohexanoic acid. Part III

100%

Paruszewski R., Tautt J., Dudkiewicz J.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 1

75-82

EN

Five peptide renin inhibitors were synthesized and their potency was assayed in vitro by a spectrofluorometric method (assay of Leu-Val-Tyr-Ser released from N-acetyltetradecapeptide substrate by renin in the presence of an inhibitor). Their stability was tested by assay of Phe and Pro-Phe released after incubation with chymotrypsin. The most potent inhibitor was Boc-Phe-His-Sta-epsilonAhx-OME, the most stable - Boc-Pro-Phe-His-Sta-epsilonAhx-OME (resistant to incubation with chymotrypsin for 4 h).

9

The effect of chronic treatment with imipramine on the G-proteins mRNA level in the rat hippocampus - an interaction with a calcium channel antagonist

100%

Lason W., Przewlocki R.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 2

219-226

EN

The effect of long-term administration of imipramine (10 mg/kg po, twice daily, 30 days) with or without nifedipine (5 mg/kg ip, twice daily, 28 days) on the G protein alfa subunit, Gs-alfa, Go-alfa and Gi-alfa mRNA levels was investigated in the rat hippocampus. An in situ hybridization histochemistry showed that imipramine decreased the Go-alfa mRNA level in CA1 (by ca. 40%) and CA3 (by ca. 37%) hippocampal fields and, to a lesser extent, in the dentate gyrus (by ca. 25%), but had no effect on the Gs-alfa and Gi-alfa mRNA levels in those structures. Nifedipine decreased (by ca. 30%) the Gs-alfa level in the studied fields of hippocampal formation, having no imfluence on the level of mRNA which codes other subunits of G protein, Coadministration of nifedipine and imipramine reversed the imipramine effect on Go-alfa, but had no effect on the nifedipine induced decrease at the Gs-alfa mRNA level. These results suggest that inhibition of L calcium channels modifies the effect of imipramine at the level of intracellular signal transduction.

10

APPLICATION OF CHITOSAN IN THE FORMULATION OF DERMATOLOGICAL HYDROGELS PREPARED ON THE BASIS OF MACROMOLECULAR COMPOUNDS

100%

Szcześniak M., Grimling B., Meler J., Karolewicz B.

Progress on Chemistry and Application of Chitin and its Derivatives

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2018

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vol. 23

179 - 184

EN

The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.

11

CHARACTERISATION AND DISSOLUTION PROPERTIES OF KETOPROFEN IN BINARY SOLID DISPERSION WITH CHITOSAN

100%

Grimling B., Górniak A., Meler J., Szcześniak M.

Progress on Chemistry and Application of Chitin and its Derivatives

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2014

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vol. 19

23-31

EN

BCS class II includes drugs with low solubility and high permeability. Ketoprofen is an example of this class of drugs. The aim of the study was to investigate the effect of chitosan with average molecular weights in various formulations on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in solid dispersions using a method of the solvent evaporations at the drug to polymer ratios of 1:9. 3:7, and 5:5. The highest dissolution of fenofibrate, amounting to 98.8%, was observed after 60 minutes from solid dispersions with a drug-polymer weight ratio 1:9 in the presence of chitosan B and was 32-times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. DSC and IR investigations showed that ketoprofen remained in its crystalline state in solid dispersion. There was no change in the chemical structure of the drug after the incorporation of the drug onto the polymer. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.

12

WHAT IS “INFLAMMATORY BOWEL DISEASE” & HOW CAN IT BE TREATED?

100%

Lustyk K., Sapa J.

Medicina Internacia Revuo

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2013

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vol. 25

|

issue 100

106- 111

EN

Ulcerative colitis and Crohn's disease are chronic diseases of the gastrointestinal tract, which are usually grouped together as inflammatory bowel disease (IBD). Despite many researches, the etiology is still unknown, but it is believed that IBD is caused by a combination of genetic and environmental factors that interact with the immunological system. Many people worldwide (around 4 million) suffer from a form IBD and the incidence of Crohn's disease is still increasing. Aminosalicylates, corticosteroids, immunomodulators, biologic medicines reduce the inflammation, relieve symptoms, prevent flare-ups, but new, more effective drugs with smaller amount of side effects are wanted and examined.

13

RH analogs with 4-nitro- and 4-N-butyloxycarbonylamino-1-methyl-2-pyrolylcarboxylic acid in position 1. Synthesis and logical properties

100%

Patalan D., Kruszynski M., Zboinska J., Kupryszewski G., Grehn L., Alexandrova M., Strbak V.

Polish Journal of Pharmacology

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1993

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vol. 45

|

issue 1

83-94

EN

Two new analogs of thyrotropin-releasing hormone TRH, obtained by the replacement of the L-pyroglutamic acid residue with 4-nitro- or 4-N-butyloxycarbonylamino-1-methyl-2-pyrolyl-carboxylic acid (analogs 1, 3), and three related derivatives, in which also the L-histidine residue was replaced with L-norvaline (analogs 2, 4) or L-norleucine (analog 5), were synthesized and tested for endocrine and central nervous system (CNS) activity. The replacement of the L-pyroglutamic acid residue with 4-nitro-1-methyl-2-pyrolylcarboxylic acid (analogs 1 and 2) resulted in the separation of the endocrine from the direct CNS activity. The effect of these analogs on the sleeping time rectal temperature and breathing frequency, was either the same or greater than that of TRH. However, neither the correlation between the binding of analogs to TRH receptors in the brain nor their activity on the CNS parameters measured was found. Analogs 3, 4 and 5, containing 4-butyloxycarbonylamino-1-methyl-2-pyrolylcarboxylic acid in place of L-pyroglutamic acid, were inactive.

14

PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH THE ADDITION OF HYDROPHILISING SUBSTANCES CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%

Małolepsza-Jarmołowska K.

Progress on Chemistry and Application of Chitin and its Derivatives

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2014

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vol. 19

95-101

EN

Research on gynaecological preparations followed that of optimising their pharmaceutical properties, which is beneficial for gynaecological powders. Gels obtained from powders containing lactic acid complexed with chitosan revealed a stoichiometric ratio 1:1, 2;1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyethylene glycol-400 increases the pH from 4.52 to 4.92 for 1:1 gels and from 2.54 to 3.41 for the 8:1 ratio. A modification of the composition of the tested powders containing 5% polyethylene glycol-400 increased the range of the dynamic viscosity of formulations suitably from 78 to 520 mPa.s for 1:1 gels and from 39 to 423 mPa.s for the 8:1 ratio. Measurements performed in a biopharmaceutical model revealed that the gels obtained from powders containing lactic acid complexed with chitosan are able to move from 25 to 28 cm.

15

Characterization of Catechins from Smilax domingensis Willd. in Cuba

100%

Soledispa P. A., González J., Cuéllar A., Pérez J., Monan M.

World News of Natural Sciences

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2019

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vol. 23

297-305

EN

Gas Chromatography coupled with mass spectrometry was applied to study the fragmentation of selected flavonoids from the ethanolic extract of Smilax domingensis Willd., Smilacaceae, known as zarzaparrilla, after Soxhlet extraction during 20 hours. Compounds belonging to one of the major subgroups found in common plants, i.e. flavanols were studied. Following solvent extraction and derivatization using BSTFA, possibly two different metabolites from the same chemical group were characterized in one analytical run: (+)-catechin and (-)-epicatechin. For the very first time, qualitative data on these analytes in the drug were determined after detailed validation of a sensitive, cheap and reliable GC-MS method.

16

ANXIOLYTIC-LIKE ACTIVITY OF PZ-1433, A NOVEL ARYLSULFONAMIDE DERIVATIVE OF ARYLOXY(PROPYL)PIPERIDINE, IN RODENTS

100%

PARTYKA A.

Medicina Internacia Revuo

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2018

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vol. 28

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issue 110

35-46

EN

A novel arylsulfonamide derivative of aryloxy(propyl)piperidine PZ-1433, has been proved to possess a preclinical activity profile appropriate for the treatment of depression and memory impairments. In the present study its pharmacological activity toward anxiety symptoms as well as its anxiolytic properties have been examined in mouse and rat models. PZ-1433 significantly increased the number of punished crossings and decreased the number of buried marbles in two tests conducted in mice. Moreover, PZ-1433 evoked anxiolytic-like activity in “conditional” anxiety paradigm in rats, meaningly increasing the number of accepted shocks in the Vogel conflict drinking test. However, it did not produce a significant anxiolytic-like effect in “unconditional” anxiety model, i.e. the elevated plus-maze test. From these results, it is likely that direct antagonism toward serotonin 5-HT7 receptors may be involved in the anxiolytic action of PZ-1433. However, in vitro detected inhibition of serotonin transporter evoked by PZ-1433, might also contribute to this effect.

17

INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

100%

Małolepsza-Jarmołowska K.

Progress on Chemistry and Application of Chitin and its Derivatives

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2022

|

vol. 27

183-193

EN

Gastro-oesophageal reflux disease is a serious social problem that affects every sphere of life. The quality of life of people with this disease is reduced due to the presence of troublesome symptoms, which translates into reduced work efficiency and vitality. The major problem is acidic gastro-oesophageal reflux. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and carboxymethylcellulose sodium salt on the protective properties of prepared gels in the treatment of acid reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. Preparations containing 0.3% carboxymethylcellulose sodium salt showed the highest pH. The texture tests showed the effect of carboxymethylcellulose sodium salt concentration on the adhesion work of the tested gels. These gels could be used in the treatment of advanced acid reflux.

18

Green tobacco sickness – A brief review

100%

Reddy M. N. T., Ashok N.

World News of Natural Sciences

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2019

|

vol. 24

209-214

EN

Green Tobacco Sickness (GTS) has been one of the unexplored areas of occupational health safety. Green Tobacco Sickness is caused by the absorption of nicotine through the skin from wet tobacco plants who have direct contact with tobacco plants during cultivation and harvesting. The present review was carried out to discuss the etiology, symptoms, diagnosis, treatment and prevention of GTS. It is caused by the absorption of nicotine through the skin while the workers are engaged in handling the uncured tobacco leaves. The symptoms include nausea, vomiting, pallor, dizziness, headaches, increased perspiration, chills, abdominal pain, diarrhea, increased salivation, prostration, weakness, breathlessness, and occasional lowering of blood pressure. The use of personal protective equipment like water‑resistant clothing, chemical‑resistant gloves, plastic aprons, and rain‑suits with boots should be used by the tobacco farmers to prevent its occurrence. An international‑level awareness campaign has to be taken up and more stringent workers safety regulations have to be formulated.

19

The effect of vasopressin analog on learning and memory processes in rats with experimental amnesia

100%

Car H., Borawska M., Wisniewski K.

Polish Journal of Pharmacology

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1993

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vol. 45

|

issue 1

11-22

EN

We investigated the effect of a single 2 microg dose of a vasopressin (AVP) analog [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP on processes of retrieval, consolidation and acquisition of conditioned reflexes in rats with experimentally induced amnesia. The investigated amnesia models were: long term ethanol intoxication, electroconvulsive shocks (ECS), and hypoxia. They all profoundly impaired the learning and memory processes in all tests used. The AVP analog - [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP facilitated retrieval of passive avoidance in all amnesia models. It improved consolidation of active avoidance of rats previously treated with alcohol, but did not affect the acquisition of active avoidance.[d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP lack antidiuretic properties.

20

THE PROPERTIES OF INTRAVAGINAL GLOBULES CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

100%

Małolepsza-Jarmołowska K.

Progress on Chemistry and Application of Chitin and its Derivatives

|

2019

|

vol. 24

127 - 134

EN

Continuing the implementation of research on the problem of treatment of vaginal pH disorders, intravaginal globules were examined as vaginal drug form which carries the lactic acid complexes with chitosan. The intravaginal application of globules that transform into gel under natural conditions is aimed at achieving the physiological pH of the vaginal environment. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional hydroxypropylmethylcellulose and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and hydroxypropylmethylcellulose in comparison to the gels without hydroxypropylmethylcellulose. The study of the work of adhesion showed the effect of hydroxypropylmethylcellulose and their concentration on the value of the work of adhesion.

Refine search results

INVESTIGATION OF FENOFIBRATE DISSOLUTION RATE INCORPORATED ON SOLID DISPERSIONS INTO CHITOSAN

The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha-1 and beta-adrenoceptors in the rat cerebral cortex

PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

Disturbances in neurotransmission processes in aging and age-related diseases

The effect of calcium channel blockade during electroconvulsive treatment on cerebral cortical adrenoceptor subpopulations in the rat

Electroconvulsive shock-induced impairment of spatial learning is aggravated by nifedipine

PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

Rennin inhibitors containinig statine and 6-aminohexanoic acid. Part III

The effect of chronic treatment with imipramine on the G-proteins mRNA level in the rat hippocampus - an interaction with a calcium channel antagonist

APPLICATION OF CHITOSAN IN THE FORMULATION OF DERMATOLOGICAL HYDROGELS PREPARED ON THE BASIS OF MACROMOLECULAR COMPOUNDS

CHARACTERISATION AND DISSOLUTION PROPERTIES OF KETOPROFEN IN BINARY SOLID DISPERSION WITH CHITOSAN

WHAT IS “INFLAMMATORY BOWEL DISEASE” & HOW CAN IT BE TREATED?

RH analogs with 4-nitro- and 4-N-butyloxycarbonylamino-1-methyl-2-pyrolylcarboxylic acid in position 1. Synthesis and logical properties

PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH THE ADDITION OF HYDROPHILISING SUBSTANCES CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

Characterization of Catechins from Smilax domingensis Willd. in Cuba

ANXIOLYTIC-LIKE ACTIVITY OF PZ-1433, A NOVEL ARYLSULFONAMIDE DERIVATIVE OF ARYLOXY(PROPYL)PIPERIDINE, IN RODENTS

INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

Green tobacco sickness – A brief review

The effect of vasopressin analog on learning and memory processes in rats with experimental amnesia

THE PROPERTIES OF INTRAVAGINAL GLOBULES CONTAINING A LACTIC ACID-CHITOSAN COMPLEX