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1

Medicinal Based Plants: A Call to Nature

100%

Awotedu O. L., Ogunbamowo P. O., Chukwudebe E. P., Ariwoola O. S.

World News of Natural Sciences

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2020

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vol. 31

92-109

EN

Herbal plants play an unprecedented role in preventing and treating of human diseases. For many years, people have been using medicinal plants in traditional medicine. Human civilization around the world have been associated with plants, however, plants are known as a rich source of phytochemical compounds that enable it to have a medicinal value. In the development of herbal and conventional drugs, medicinal plants are potential sources. In the 21st century, medicinal plants have been considered due to its pharmacological effects as a promising drug for the management of diverse health implication. The resurgence of interest to discover medicinal plants as a potential source of new drug has become imperative. Even though synthetic drugs are gaining ground in the healthcare system all over the world, however, available evidences suggest that nature will be a pointer for drug discovery. Hence, there is a need to understand and discover the knowledge of medicinal plants as a rich source of herbal drugs knowing fully well its active compositions.

2

Investigating pH-Dependent Modulations in Haemoglobin Response to Linoleic Acid: A Spectroscopic Analysis

100%

Adaeze B. C.-A., Ikechukwu C.

World News of Natural Sciences

|

2024

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vol. 53

231-243

EN

This study investigates the pH-dependent modulations in haemoglobin response to linoleic acid, employing a spectroscopic analysis across HbAA, HbAS, and HbSS variants. Concentration-dependent effects of linoleic acid at varying pH levels reveal nuanced behaviours in absorbance, peak maintenance, and spectra characteristics. At pH 7.2, HbAA and HbSS display increased absorbance with peak maintenance, while HbAS exhibits gradual absorbance rise. pH 5.0 induces absorbance increase in all variants, with maintained peaks at 415nm and gradual decrease at the oxy-band region. Variants exhibit distinct spectra characteristics, emphasizing the need for tailored approaches in clinical management. Findings align with empirical literature, emphasizing haemoglobin's multifunctionality. Implications span clinical considerations, dietary influences, and broader insights into haemoglobin stability. Suggestions for future studies propose molecular explorations, disease-specific investigations, computational modelling integration, longitudinal studies, and intervention strategy explorations. This study contributes to the evolving understanding of haemoglobin responses to environmental factors, laying groundwork for personalized approaches in healthcare and dietary recommendations.

3

A study on the toxicity of aluminum in rice, Oryza sativa L.

100%

Muthukumaran M.

World News of Natural Sciences

|

2022

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vol. 40

13-25

EN

Aluminum trivalent (Al3+), which commonly occurs on 40% of arable land, is highly phytotoxic to crop growth and yield in acidic soils. As one of the major pollutants in the atmosphere, this element reduces chlorophyll activity, CO2 assimilation, and photosynthesis. Rice is a staple food crop in India and Asian countries. A widely recognized metal toxicity of rice (Oryza sativa) includes soluble aluminum. The processes of senescence are known to be characterized by loss of chlorophyll, lipids, total protein, photosynthetic activity, and RNA. The author illustrates the aluminum effect in rice plants (ADT 43 & PA 6129) under different aluminum exposure levels (100 µM, 200 µM, & 300 µM), in regard to photosynthetic activity (total chlorophyll degradation, depleted CO2 fixation, inhibited stomatal conductance) bioaccumulation, and histological analysis during leaf senescence. Rice varieties PA 6129 and ADT 43 were compared to assess photosynthetic degradation, bioaccumulation, and histological changes associated with aluminum-mediated degradation. Consequently, accelerated leaf senescence was observed after prolonged exposure to variety PA 6129 with increasing aluminum concentration. As an alternative, there is ADT 43, a precision aluminum tolerance mechanism.

4

Materiały konferencyjne Collegium Medicum UJ: sesja konkursowa - aktualne kierunki chemii medycznej

100%

Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe

|

2014

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issue 8

21-32

5

Chemical composition of Dacyrodes edulis seed oil

100%

Okafor N. A., Ezim O. E., Anadebe V. C., Ume C. S.

World News of Natural Sciences

|

2017

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vol. 14

72-78

EN

Dacyrodes edulis seed were collected peeled, dried and powdered. The oil were extracted by simple method of cold extraction, the extracts were characterized by the Phytochemical analysis, Fourier transform infrared spectroscopy (FTIR) and Gas Chromatography (GC) to identify the fatty acid profile present in the seed oil. The FTIR analysis shows the variation of the peaks which indicate there is synergy among the functional groups of the extract. The phytochemical analysis revealed the presence of alkaloids, flavonoids, phenol, saponins, tannins and steroids, the study reveal the chemical constituents of Dacyrodes edulis seed oil that these constituents may be behind their medicinal values in phytomedicine.

6

ZINC, THE TRACE ELEMENT ESSENTIAL IN LIVING ORGANISMS

100%

SOLÉ PASCUAL A., TYSZKA-CZOCHARA M., GDULA-ARGASIŃSKA J., LIBROWSKI T., GRZYWACZ A., OPOKA W.

Medicina Internacia Revuo

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2012

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vol. 25

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issue 99

55-59

EN

Zinc is a metallic element, of symbol Zn and atomic number 30, that is placed in the group 12 of the periodic table. As an essential trace element, zinc is required to support human biochemical processes. It is found in nearly 200 specific enzymes in the living organisms, and it also serves as structural cofactor for many cellular proteins. [1] Zinc may exert pleiotropic effects in organism; for that, deficits of cellular zinc content can have catastrophic consequences and are linked to major pathophysiology, such as diabetes, stroke and malformations of brain function [2]. The complexity and importance of zinc homeostasis is reflected by the large variety and number of zinc-related proteins found in almost every cell compartment; for example, this biometal is transported through ZnT (Zn2+ transporter) family and ZIP family, proteins that are completely dedicated to zinc transport [2]. It is also noticeable, that between three and ten percent of all protein products of genes in mammalian genomes bind zinc, which is essential for their folding, activity or conformational change [2].

7

Phytochemical and in vitro antioxidant assessment of Yoyo bitters

100%

James-Okoro P.-P. O., Iheagwam F. N., Sholeye M. I., Umoren I. A., Adetuyi B. O., Ogundipe A. E., Braimah A. A., Adekunbi T. S., Ogunlana O. E., Ogunlana O. O.

World News of Natural Sciences

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2021

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vol. 37

1-17

EN

In this paper, herbal bitters are widely used due to their numerous acclaimed health benefits in many Nigerian homes; however, many have not been subjected to scientific scrutiny. The aim of this study was to determine the phytochemical composition and antioxidant capacity of a non-alcoholic polyherbal formulation, Yoyo bitters, towards validating its broad pharmacological claims. The phytochemical components of Yoyo bitters were ascertained by phytochemical screening assays and gas chromatography-mass spectrometry (GC-MS). The antioxidant activity was investigated in vitro using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) scavenging activity, total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays. Qualitative phytochemical analysis of Yoyo bitters showed the presence of saponins, tannins, flavonoids, terpenoids, cardiac glycosides and anthocyanins. The total phenols, flavonoids, flavanols, tannins and carotenoids content were 14.741 ±0.64 mg GAE/ml, 0.152 ±0.01 mg RE/ml, 0.437 ±0.02 mg RE/ml, 0.368 ±0.04 mg TAE/ml and 0.016 ±0.00 mg CAE/ml respectively. GC-MS chromatogram revealed the presence of forty-three (43) phytochemical compounds with D-allose (41.81%), 1,6-anhydro-beta-D-glucofuranose (24.15%), 5-hydroxymethylfurfural (8.02%) and Z-6-pentadecen-1-ol acetate (3.50%) as the most abundant constituents. Yoyo bitters demonstrated effective antioxidant activity against DPPH and H2O2 with IC50 values of 0.492 mg/ml and 0.629 mg/ml respectively compared to ascorbic acid of 0.161 mg/ml and 0.130 mg/ml respectively. Total antioxidant capacity and ferric reducing antioxidant power of Yoyo bitters were 0.432 mg AAE/ml and 2.236 mg AAE/ml respectively. This study validates the antioxidant capacity of Yoyo bitters and provides chemical basis for its acclaimed pharmacological actions.

8

Batch adsorption of malachite green dye from aqueous solution using sawdust of Swietenia macrophylla (mahogany wood)

100%

Opia C. F., Obinna N. V., Chizoruo I. F., Obinna I. B.

World News of Natural Sciences

|

2023

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vol. 50

222-246

EN

Sawdust of Swietenia macrophylla waste was used as a bio-sorbent for the removal malachite green from aqueous solutions in this study. Various parameters’ effect such as contact time, pH, initial dye concentration, temperature and adsorbent dosage were studied on the bio-sorbent. Spectrophotometric technique was implemented for the measurement of dye concentration before and after adsorption. The study indicated that the quantity of dye adsorbed increased steadily with increase in the dye’s initial concentration and contact time because as the concentration increases the dye molecules available for adsorption also increases. There was a sharp rise in the quantity of dye adsorbed as the pH increases from pH 2 to pH 7, equilibrium was obtained at pH 10 after which the quantity of dye adsorbed decreased with an increased to pH 12. As the temperature increases the quantity of dye adsorbed decreased, this can be attributed to an increase in solubility as the temperature increases. The experimental data were fitted to the Langmuir and Freundlich adsorption isotherms with Langmuir isotherm showing a better fit than Freundlich isotherm model, this shows that the adsorption follows a homogenous coverage signifying saturated monolayer coverage of the solute molecules on the adsorbent surface. The adsorption kinetics data were fitted to pseudo-first and pseudo-second order kinetic model with pseudo-second order kinetic model showing a better fit than pseudo-first order kinetic model, indicating that more than one process affects the adsorption of malachite green dye onto Swietenia macrophylla. In terms of thermodynamic parameters, negative values were obtained for Gibbs free energy ∆G o, indicating a spontaneous adsorption process; also the enthalpy change ∆H° was negative signifying the adsorption is exothermic in nature. Similarly, entropy ∆S° values were negative indicating that the degree of disorderliness of malachite green reduced as it got adsorbed onto the surface of the adsorbent.

9

Ameliorative Effect of Ethanolic Extract of Laportea aestuans (L.) Chew on Gastric Oxidative Damage in Aspirin - Induced Gastric Ulcer in Male Rats

100%

Onadeko A., Akinola O.

World News of Natural Sciences

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2021

|

vol. 39

86-94

EN

Non-steroidal anti-inflammatory drugs (NSAIDs) are connected with the generation of free radicals and one of its adverse effects is gastric ulceration. Ulceration was induced orally using aspirin. Twenty-four male Wistar rats were used for this study (120-150g). Rats were divided into 6 groups with each group containing 4 rats. Rats were pre-treated orally with cimetidine, a reference drug. Group 1 rats orally received 1% gum acacia solution as the control group, Group 2 rats orally administered 25 mg/kg aspirin and served as the ulcerated, untreated group, rats in groups 3 and 4 were pre-treated orally with 200 mg/kg and 400 mg/kg respectively for 3 days while rats in groups 5 and 6 were pre-treated orally with 50 mg/kg cimetidine and 50 mg/kg catechin respectively for 3 days. The result of this study shows that the ulcerated, untreated rats showed increased concentrations of gastric volume with a concomitant decrease in protein concentration compared to the control group, cimetidine and catechin reversed these observations. Activities of glutathione, catalase were decreased in the ulcerated, untreated group but pre-treatment with different doses, cimetidine and catechin reversed these observations. In conclusion, the ethanoic extract of L. aestuans can be said to be used as an anti-ulcerogenic agent against aspirin-induced gastric ulcer which is due to the presence of phytochemicals in the plant.

10

Biosynthesis of cobalt oxide (Co3O4) nanoparticles using plant extract of Camellia sinensis (L.) Kuntze and Apium graveolens L. as the antibacterial application

100%

Urabe A. A., Aziz W. J.

World News of Natural Sciences

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2019

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vol. 24

356-364

EN

In this work, we prepared cobalt oxide nanoparticles using Celery stalks and green tea leaves extract. The synthesized cobalt-oxide NPs were characterized using X-Ray diffraction. This showed the highest peak and top control (222) at (38.18 degree) with regard to Camellia sinensis extract and (220) at (30.14 degree) for Apium graveolens extract, Field Emission scanning electron microscopy (EF_SEM) at the range of 21-72 nm, revealed the highly uniform shape of particles, while UV-Visible spectroscopy techniques recorded the highest value of the absorptive at 230 nm and the energy band gap to be 3.55 eV for Camellia sinensis and 225 nm and energy band gap 3.85 eV at Apium graveolens, respectively. Our results indicate that the best achievable result in inhibiting bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa comes by way of using Camellia sinensis extract (27-29 mm).

11

Biomateriały stosowane w inżynierii tkankowej do regeneracji tkanek

100%

Laska A.

Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe

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2017

|

issue 14

187-196

EN

Tissue engineering is an interdisciplinary field of science that develops very intensively in recent years. New ways of treatment of damaged tissues and organs are constantly sought. Scaffolds for cell culture appear to be a breakthrough solution with great implementation possibilities in regenerative medicine. Currently, various porous structures supporting adhesion, cell differentiation and cell proliferation are investigated and developed. Choosing the right biomaterial for tissue regeneration is one of the key issues in designing scaffolds and entire treatment process. There is a numerous group of biomaterials used in scaffold production. It is worth listing such as polylactide (PLA), polyglycolide (PGA), polylactide-glycolide (PLGA), polycapro- lactone (PCL), chitin, collagen, bioactive calcium phosphate (TCP) and hydroxyapatite (HAp). The purpose of this paper is to present a literature review of the biomaterials used for the production of three-dimensional scaffolds for cell culture. Discussed materials are divided into three groups, i.e. polymers, ceramics and metals.

PL

Inżynieria tkankowa jest interdyscyplinarną dziedziną nauki, rozwijającą się bardzo intensywnie w ostatnich kilkunastu latach. Nowe sposoby leczenia uszkodzonych tka- nek i narządów są nieustannie poszukiwane. Rusztowania tkankowe do hodowli komórki pacjenta wydają się przełomowym rozwiązaniem, mającym ogromne możliwości wdrożeniowe w medycynie regeneracyjnej. Aktualnie bada się różnorodne porowate struktury wspierające adhezję, różnicowanie i proliferację komórek. Dobór odpowiedniego biomateriału, na którym będzie się rozwijać nowa tkanka pacjenta, jest jednym z kluczowych zagadnień w trakcie projektowania nowoczesnego rusztowania tkankowego i całego procesu leczenia. Spośród licznej grupy biomateriałów stosowanych do wytwarzania trójwymiarowych skafoldów na szczególną uwagę za- sługują biodegradowalne polimery, takie jak polilaktyd (PLA), poliglikolid (PGA), ko- polimer polilaktyd-glikolid (PLGA), polikaprolakton (PCL), chityna, kolagen oraz bioaktywna ceramika – trójfosforan wapnia (TCP) i hydroksyapatyt (HAp). Celem niniejszej pracy jest przedstawienie przeglądu literaturowego dotyczącego biomateriałów wykorzystywanych do wytwarzania trójwymiarowych rusztowań tkankowych do hodowli komórkowej. Stosowane materiały podzielono na trzy grupy – polimery, cerami- kę i metale – z uwzględnieniem aktualnie panujących trendów.

12

Synthesis, spectral analysis and antimicrobial activity of 2(1H)-quinolinone tethered 1,3,5-triazine derivatives

100%

Savaniya N. P., Khakhariya A. D., Pankhaniya P. P., Ladva K. D.

World News of Natural Sciences

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2024

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vol. 55

25-32

EN

A series of novel quinolinone containing 1,3,5-triazine derivatives have been synthesized, characterized and screened for antimicrobial activity. 7-((4-((3-fluoro-4-morpholinophenyl)amino)-6-(arylamino)-1,3,5-triazin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one derivatives were prepared by condensation of 7-((4-chloro-6-((3-fluoro-4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)oxy)-3,4-dihydroquinolin-2(1H)-one with differently substituted aniline derivatives. The designed compounds were confirmed via IR, 1H NMR, Mass spectral data. The synthesized compounds checked for their antimicrobial activity using gram-positive bacteria, gram-negative bacteria and fungi against standard drugs.

13

Spectroscopic analysis of phytochemical compounds in Garcina kola leaf extract

100%

Anadebe V. C., Okafor N. A., Okafor B. O., Emmanuel C. C.

World News of Natural Sciences

|

2017

|

vol. 15

162-168

EN

Garcina kola leaves were collected, washed, dried and powdered. The ethanol extracts were first prepared by the simple method of cold extraction. The extracts were then characterized by the Phytochemical analysis, Fourier transform infrared spectroscopy (FTIR) and Gas chromatography mass spectroscopy (GC-MS) to identify the fatty acids and heterocyclic compounds present in the leaf extracts. The FTIR analysis shows a variation of the peaks that indicate there is synergy among the functional groups of the extract. Moreover, the phytochemical analysis revealed the presence of alkaloids, flavonoids, phenol, saponins, tannins and steroids. The study reveals that the chemical constituents of Garcina kola leaf may be behind their medicinal values in phytomedicine.

14

Changes in the reproductive hormone levels of male and female rats consuming monosodium glutamate and soybean extracts

100%

Agada A. B.-C., Ohiagu F. O.

World News of Natural Sciences

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2023

|

vol. 51

70-82

EN

The present study sought to analyze the possible changes that might be caused by MSG and soybean on the secretion of both the male and female reproductive hormones in wistar rats. Two hundred and ten wistar rats (105 female and 105 male rats) were used for this study. The 105 female rats were equally divided into three groups representing the various experimental durations of 2, 4, and 6 months. Each of these groups consisting of 35 rats were further divided equally into 7 subgroups each containing 5 rats. 3 out of the 7 subgroups were orally administered MSG, another 3 out of the 7 subgroups were orally administered soybean according to the established LD50 as follows: 1000 mg/kg b.w (low dose, LD), 2000 mg/kg b.w (medium dose, MD), 3000 mg/kg b.w (High dose, HD) daily, while the 7th group served as the control group and was given only water and normal rat chow. The 105 male rats were also grouped in same manner and orally administered the MSG and soybean. The levels of LH, FSH, progesterone (PRG), oestrogen (E2) and testosterone were analyzed by ELISA technique. Long period administration of MSG significantly (p<0.05) decreased the levels of LH, PRG, E2 and FSH in the female rats when compared with the control group. Consumption of soybean for a long period of time significantly (p<0.05) decreased the level of E2 and FSH in the female rats, while short period administration significantly (p<0.05) increased the PRG level and long period administration significantly (p<0.05) decreased the PRG level in comparison with the control. Long and short period consumption of MSG as well as soybean significantly (p<0.05) decreased the levels of testosterone and LH in the male rats, while only long period administration of both significantly (p<0.05) decreased the level of FSH in the male rats when compared with the control group. The consumption of both small and large amounts of MSG and soybean elicit reproductive hormonal imbalance irrespective of the gender through the alteration of the levels of FSH, LH, E2, testesterone and PRG.

15

Infrared Studies and Mineral Element Analysis of the leaf of Vernonia amygdalina

100%

Duru I. A., Duru C. E.

World News of Natural Sciences

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2017

|

vol. 13

1-9

EN

Used in traditional medicine, infrared characterization of column eluates and elemental analysis of V. amygdalina was carried out to establish preliminary views of the chemical and mineral element composition of the leaf of this plant. In the five pure eluates obtained, we found that they contained saturated aliphatic esters, nitro-groups conjugated with benzene ring, secondary amines/nitrogen heterocycles, 1,3-disubstituted benzene and oxazine/oxazoline fragments, respectively. Moreover, we established that potassium, magnesium and sodium were the major minerals in the leaf, while copper, zinc, iron, nickel, manganese and chromium occurred in trace amounts. Research attention should therefore be focused on this plant for the full exploration and exploitation of its obvious antibiotic and mineral values.

16

Phytoconstitution and Antioxidant Activity of the Ethanolic Extract of an Antimalarial Herbal Mixture

100%

Odokwo E. O., Onifade M. S.

World News of Natural Sciences

|

2024

|

vol. 54

38-44

EN

The phytoconstitution and antioxidant profiling of mixture of herbs used in the treatment of malaria has been carried out. Herbs used as alternative medicines in the local treatment of malaria were collected from a herbal vendor in Ibadan. The herbal materials were extracted using absolute ethanol and the crude extract, EEA subjected to qualitative phytochemical screening and 2,2-diphenyl-1-picrylhydrazyl (DPPH) standard procedures. The presence of alkaloids, saponins, tannins, terpeniods, flavonoids and phenols were identified. EEA was found to exhibit antioxidant activity in the dose range of 25-400 μgml-1. The significant presence of major series of phytochemicals has justified the associated antimalarial ethnomedicinal claim. Thus, the present study has established the phytoconstitution and antioxidant activity of an antimalaria herbal mixture.

17

Isolation of Flavonoids, Antioxidant and Antimicrobial Activities of Costus afer Ker Gawl. Stem Extracts

100%

Ekoro I. A., Edema M. O., Ogwuche C. E.

World News of Natural Sciences

|

2024

|

vol. 53

1-16

EN

ABSTRACT Resistance to antimicrobial agents has become an increasingly important and pressing global problem. Hence, the need for substantial investment and research in the field of anti-infectives are now desperately needed if a public health crisis is to be averted. This study aims to determine the antioxidant and antimicrobial activity of Costus afer stem and isolate the flavonoids in the extracts. The method used for isolation was a combination of thin layer chromatography (TLC) and column chromatography (CC). Phytochemical screening tests were used for identification of the eluate fractions of CC to ascertain the flavonoid-rich fraction. The flavonoid content in dry stem extracts (DSE); 153 µg/g was lesser than that in fresh stem extracts (FSE) 186 µg/g. All the extracts showed activity against test organisms (Staphylococcus aureus, Escherichia coli, Pseudomonas spp.) in a concentration-dependent manner. There was an observed resistance of S. aureus against FSE at 25 mg/ml. E.coli and Pseudomonas spp were sensitive to DSE at almost all concentrations Pseudomonas spp was sensitive to almost all the control drugs except cefuroxime where it recorded a resistance. DPPH radical scavenging activity was positively correlated to the concentration of the stem extracts. FSE sample showed higher DPPH radical scavenging activity than DSE as evident in Table 3 and Fig. 2. The reducing power of the extracts followed the order of DSE < FSE < VITC. ABTS radical scavenging activity was also positively correlated to the concentrations of the stem extracts. In this analysis, FSE sample showed higher radical scavenging activity of ABTS than the DSE sample.

18

Trace metal, FTIR and phytochemical analysis of Viscum album leaves harvested from Pentaclethra macrophylla

100%

Chizoruo I. F., Onyekachi I. B., Ebere E. C.

World News of Natural Sciences

|

2019

|

vol. 25

61-71

EN

The leaves of mistletoe (Viscum album) harvested from oil bean tree (Pentaclethra macrophylla) in Imo State South Eastern Nigeria was studied. The study was aimed at carrying out trace metal, Fourier Transform Infra-red (FTIR) and phytochemical analysis of ethanol leave extracts of Viscum album harvested from Pentaclethra macrophylla. The sample for trace metal analysis was digested with a mixture of concentrated HNO3 and HClO4 at a ratio of 1:1 for 24 hours. Ethanol was then used to extract the sample meant for FTIR and phytochemical analysis. Herein, trace metal determination indicates the presence of Mg, Zn, Fe, Cu and Cr, and the concentration of Ca and Mn is at < 0.00 mg/kg. The result of the phytochemical screening demonstrates the presence of flavonoids, alkaloids, phenols, saponins and tannins. FTIR analysis confirmed the presence of alcohols, amides, aromatics and carbonyl compounds in ethanol extracts of Viscum album harvested from Pentaclethra macrophylla. The presence of some trace metals and phytochemicals, as well as some important functional groups in the plant sample, as indicated by the result of the study, authenticates its use in traditional medicine.

19

Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives

100%

Vishnupriya P., Rubala mary M.

World News of Natural Sciences

|

2018

|

vol. 18

|

issue 2

72-78

EN

The tremendous rise in development of resistance to antimicrobials has created an alarming situation for researchers and clinicians. In this regard, an attempt has been made to develop a series of azole-based derivatives. The presented study consists of the design and synthesis of some newer derivatives by incorporating the isoxazole nucleus in the pharmacophore. These are also characterized physicochemically and by spectral means (IR and microanalysis). Moreover, the antioxidant activity of these derivatives was assessed using DPPH radical scavenging methods Finally, all of the newly isolated compounds were tested for their antimicrobial activities. Herein, antimicrobial screening using the agar disc diffusion method revealed that the majority of the derivatives are most active.

20

Mechanism of Action of Chaperones in Protein Function

100%

Adio W. S., Obunadike C. V., Ogunsanmi A. O.

World News of Natural Sciences

|

2022

|

vol. 44

333-354

EN

The building blocks of living cells, proteins are enormous collections of nitrogenous organic molecules that are polymers of the amino acids that animals must consume to grow and repair their tissues. ATP-dependent proteins known as chaperones serve as foldases (protein folding assistants), holdases (bind folding intermediates), and disaggregates (convert aberrant protein to monomers). Chaperones include, but are not limited to, DnaJ, DnaK, GrpE, and Hsp33. The majority of chaperones have a cleft containing the nucleotide-binding site that divides the ATPase domain into two subdomains. The features of the C-terminal domain depend on the kind of bound nucleotide. In the presence of ATP, peptides bind and dissociate quickly and with low affinity. In contrast, the affinity increases significantly while the rate of peptide binding reduces when neither ADP nor nucleotide are connected to the N-terminal domain. Hsp90 is a homodimer with a 60 n dissociation constant. In reaction to high temperature or other types of cellular stress that prevent protein folding, several chaperones turn on their activity. Neurodegenerative, Parkinson's, and polyQ diseases, among others, can all be treated with chaperones. This is possible when a protein prevents the accumulation of protein species with improper folding. The suppression of dangerous protein oligomers by clustering, illness response related to protein aggregation, and cancer maintenance are a few new functions for chaperones that are still being discovered.

Refine search results

Medicinal Based Plants: A Call to Nature

Investigating pH-Dependent Modulations in Haemoglobin Response to Linoleic Acid: A Spectroscopic Analysis

A study on the toxicity of aluminum in rice, Oryza sativa L.

Materiały konferencyjne Collegium Medicum UJ: sesja konkursowa - aktualne kierunki chemii medycznej

Chemical composition of Dacyrodes edulis seed oil

ZINC, THE TRACE ELEMENT ESSENTIAL IN LIVING ORGANISMS

Phytochemical and in vitro antioxidant assessment of Yoyo bitters

Batch adsorption of malachite green dye from aqueous solution using sawdust of Swietenia macrophylla (mahogany wood)

Ameliorative Effect of Ethanolic Extract of Laportea aestuans (L.) Chew on Gastric Oxidative Damage in Aspirin - Induced Gastric Ulcer in Male Rats

Biosynthesis of cobalt oxide (Co3O4) nanoparticles using plant extract of Camellia sinensis (L.) Kuntze and Apium graveolens L. as the antibacterial application

Biomateriały stosowane w inżynierii tkankowej do regeneracji tkanek

Synthesis, spectral analysis and antimicrobial activity of 2(1H)-quinolinone tethered 1,3,5-triazine derivatives

Spectroscopic analysis of phytochemical compounds in Garcina kola leaf extract

Changes in the reproductive hormone levels of male and female rats consuming monosodium glutamate and soybean extracts

Infrared Studies and Mineral Element Analysis of the leaf of Vernonia amygdalina

Phytoconstitution and Antioxidant Activity of the Ethanolic Extract of an Antimalarial Herbal Mixture

Isolation of Flavonoids, Antioxidant and Antimicrobial Activities of Costus afer Ker Gawl. Stem Extracts

Trace metal, FTIR and phytochemical analysis of Viscum album leaves harvested from Pentaclethra macrophylla

Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives

Mechanism of Action of Chaperones in Protein Function