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Effect of zinc oxide nanoparticles on the expression of proinflammatory proteins in murine macrophages raw 264.7 cells

100%
Olbert M., Gryc K., SROCZYŃSKA K., ZAJĄC A., LIPKOWSKA A., LIBROWSKI T., GDULA-ARGASIŃSKA J.
Medicina Internacia Revuo
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2017
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vol. 28
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issue 109
262-265
EN
Zinc is a microelement essential for the body. It has a great impact on the proper development and renewal of tissues, reproductive system, skin condition, or immune processes. Zincis involved practically in all aspects of the immune system and the production and activation of white blood cells. This work aimed to determine the effect of zinc oxide nanoparticles (ZnONP) on the expression of pro-inflammatory proteins in murine macrophages RAW 264.7, activated with lipopolysaccharide (LPS). Using the immunodetection technique the expression of cyclooxygenase 2 (COX-2), prostaglandin E2 synthase (cPGES), prostaglandin F2α receptor (FP receptor) and nuclear factor Nrf2 was determined. Statistically the highest expression of COX-2, cPGES, and FP receptor was observed in LPS-activated macrophages. RAW 264.7 cells supplementation with ZnONP 100 nmol and 500 nmol and LPS activation resulted in repression of COX-2 and cPGES, and an increased expression of Nrf2 protein when compared to control. The results suggest an anti-inflammatory effect and activation of the antioxidant system by ZnONP in RAW 264.7 macrophages. It seems appropriate to conduct further research on the molecular mechanism of action of ZnONP in eukaryotic cells.
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THE INFLUENCE OF KETOPROFEN AND ZINC OXIDE NANOPARTICLES ON SERUM COPPER LEVEL IN RATS

88%
Medicina Internacia Revuo
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2018
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vol. 28
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issue 110
11-22
EN
The role of copper in anti-inflammatory response includes several mechanisms. Antagonism between zinc (Zn) and copper (Cu) and proper balance between the two elements in the organism may affect the course of inflammatory diseases. Copper is a component of Zn/Cu superoxide dismutase (Zn/Cu SOD) and other enzymes involved in the anti-inflammatory response of the organism. To investigate the serum copper level during inflammation and diseases, numerous researches were conducted. Copper deficiency or copper intoxication may lead to biological consequences. Copper deficiency may be caused by various factors, one of them is excessive zinc supplementation. The aim of the study was to investigate the alterations in the serum copper level after 2-week zinc oxide nanoparticles (NPs-ZnO) administration. The second aim was to investigate serum copper level alterations after 2-week NPs-ZnO and single ketoprofen administration. The inflammatory state was induced in each group by the carrageenan injection at the 15th day of the experiment. The results indicate for the decrease in serum copper level in group receiving NPs-ZnO compared to control. Moreover, in groups receiving NPs-ZnO as well as ketoprofen, a decrease in serum copper level was observed. We may conclude that NPs-ZnO administration and also ketoprofen administration acts as anti-inflammatory agents and may induce a decrease in serum copper level.
3
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Insecticidal efficiency and safety of zinc oxide and hydrophilic silica nanoparticles against some stored seed insects

75%
Haroun S. A., Elnaggar M. E., Zein D. M., Gad R. I., Haroun S. A., Elnaggar M. E., Zein D. M., Gad R. I.
Journal of Plant Protection Research
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2020
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vol. 60
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issue 1
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