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Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer’s disease

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Hosoi T., Nomura J., Ozawa K., Nishi A., Nomura Y.
Endoplasmic Reticulum Stress in Diseases
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2015
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vol. 2
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issue 1
EN
The endoplasmic reticulum (ER) is an organelle that plays a crucial role in protein quality control such as protein folding. Evidence to indicate the involvement of ER in maintaining cellular homeostasis is increasing. However, when cells are exposed to stressful conditions, which perturb ER function, unfolded proteins accumulate leading to ER stress. Cells then activate the unfolded protein response (UPR) to cope with this stressful condition. In the present review, we will discuss and summarize recent advances in research on the basic mechanisms of the UPR. We also discuss the possible involvement of ER stress in the pathogenesis of Alzheimer’s disease (AD). Potential therapeutic opportunities for diseases targeting ER stress is also described.
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Genesis of ER Stress in Huntington’s Disease

86%
Shenkman M., Eiger H., Lederkremer G. Z.
Endoplasmic Reticulum Stress in Diseases
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2015
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vol. 2
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issue 1
EN
Recent research has identified ER stress as a major mechanism implicated in cytotoxicity in many neurodegenerative diseases, among them Huntington’s disease. This genetic disorder is of late-onset, progressive and fatal, affecting cognition and movement. There is presently no cure nor any effective therapy for the disease. This review focuses on recent findings that shed light on the mechanisms of the advent and development of ER stress in Huntington’s disease and on its implications, highlighting possible therapeutic avenues that are being or could be explored.
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