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EN
Soft tissue angiofibroma is a benign vascular neoplasm that occurs predominantly in the nasopharynx area of adolescent males. Primary extranasopharyngeal location without involvement of the nasopharynx is unusual and tends to occur at a later age. Extra nasopharyngeal angiofibromas are clinically different from juvenile nasopharyngeal angiofibromas. According to a vast literature search, presenting angiofibroma in the oral cavity is extremely rare. Extranasopharyngeal angiofibroma arising from the ridge of the maxilla in the oral cavity has not been reported up to now and this case is probably the first to be reported.
EN
Introduction: Tumors which most frequently metastasize to the heart include: malignant melanoma, lung cancer, breast cancer, ovarian cancer, kidney cancer, leukemia, lymphomas and esophageal cancer. Purpose: The purpose of this paper was clinical analysis of a group of patients operated in deep hypothermic circulatory arrest due to tumors of the right atrium and the inferior vena cava. Material and method: The study covered 7 patients operated at the Cardiac Surgery Clinic with a cardiac tumor diagnosed on the basis of an echocardiographic assessment in the years 2012–2019. Before qualifying for surgical treatment, each patient underwent: thorough interview and physical examination, 12-lead ECG, laboratory tests and echocardiography. Patients additionally underwent: computed tomography of the chest or abdomen, magnetic resonance imaging and coronary angiography on the basis of which patients with significant coronary artery changes underwent simultaneous coronary artery bypass graft. After preparation, the tumor was excised from the vena cava and right atrium with simultaneous removal of the primary tumor, most often kidney cancer. Early and distant results of treatment were analyzed in the examined group of patients to determine the following endpoints: hospital mortality and survival after surgery: after 3 months and 12 months. Results: Of all operated patients: 2 individuals died in the early postoperative period due to hemorrhagic complications (hospital mortality – 28.6%), and 5 patients (71.4%) were discharged from the Clinic in a good general condition. In total, 3-month survival was 71.4%, and 12-month survival amounted to 28.6%. Conclusions: Surgeries are very complex and challenging, and usually take on average 8–10 hours. It can improve the outcomes of palliative oncological treatment, better physical function (cardiovascular fitness) and extend life from several months to several years in more than ²/3 patients.
EN
We report a case of rare solitary pancreatic tuberculoma. 70 years old woman admitted to hospital in order to conduct diagnostics of a tumor located in the head of the pancreas. All symptoms pointed at pancreatic cancer, but histopathological examinations were inconclusive. Additionally, there were no clinical signs or symptoms of tuberculosis in the lungs. X-ray of the chest showed no abnormalities. The patient denied tuberculosis in the medical interview. There were no bacilli in the sputum. During exploratory laparotomy, the samples of tissue have been taken for pathomorphological examination. The microscopic image caused suspicion of Mycobacterium tuberculosis etiology, which was confirmed by Ziehl-Neelsen staining. In recent years, tuberculosis has become more and more common in Europe, which is why the described case can be a guide for doctors to help to avoid diagnostic errors and speed up the treatment process.
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Direct tumor damage mechanisms of photodynamic therapy.

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EN
Photodynamic therapy (PDT) is a clinically approved and rapidly developing cancer treatment regimen. It is a minimally invasive two-stage procedure that requires administration of a photosensitizing agent followed by illumination of the tumor with visible light usually generated by laser sources. A third component of PDT is molecular oxygen which is required for the most effective antitumor effects. In the presence of the latter, light of an appropriate wavelength excites the photosensitizer thereby producing cytotoxic intermediates that damage cellular structures. PDT has been approved in many countries for the treatment of lung, esophageal, bladder, skin and head and neck cancers. The antitumor effects of this treatment result from the combination of direct tumor cell photodamage, destruction of tumor vasculature and activation of an immune response. The mechanisms of the direct photodamage of tumor cells, the signaling pathways that lead to apoptosis or survival of sublethaly damaged cells, and potential novel strategies of improving the antitumor efficacy of PDT are discussed.
EN
In the current case report we present a novel case of a successful coil embolization of the left internal carotid artery aneurysm. The patient presented with neck pain and a palpable pulsating tumor and was admitted to the vascular surgery clinic where an angio-CT scan of the neck was performed. Angio-CT revealed a left internal carotid artery aneurysm with a narrow neck. The patient was admitted to the department of vascular surgery where she was enrolled into endovascular coil embolization. After the procedure, control angiography showed complete embolization of the aneurysm. Three months following the procedure, doppler ultrasonography of the carotid arteries showed no demonstrable flow into the aneurysm. Six months following the procedure, angio-CT confirmed complete aneurysm thrombosis. Based on this case, endovascular coil embolization of the carotid artery aneurysms is a safe and effective method of treatment.
EN
The aim of this study was to assess short-term outcomes of surgical treatment of pancreatic cystic tumors (PCTs). Material and methods: We retrospectively reviewed medical records of 46 patients (31 women and 15 men) who had undergone surgery for pancreatic cystic tumors in our department. Results: Pancreatic cystic tumors were located within the pancreatic head (21), body (11), tail (13), and whole pancreas (1). The following surgical procedures were performed: pancreatoduodenectomy (20), central pancreatectomy (9), distal pancreatectomy (3), distal pancreatectomy with splenectomy (3), distal extended pancreatectomy with splenectomy (2), total pancreatectomy (1), duodenum preserving pancreatic head resection (1), local tumor resection (4), and other procedures (2). Histopathological tumor types were as follows: serous cystadenoma (14), intraductal papillary mucinous adenoma (5), intraductal papillary mucinous carcinoma (5), solid pseudopapillary tumor (5), mucinous cystadenoma (5), mucinous cystadenoma with border malignancy (1), mucinous cystadenocarcinoma (2), adenocarcinoma (4), and other tumors (5). Early postoperative complications were observed in 14 (30.43%) patients. Reoperations were performed in 9 (19.56%) patients. The perioperative mortality rate was 6.52%. Conclusions: Serous cystadenoma was the most common pancreatic cystic tumor in the analyzed group. PCTs were most frequently located within the pancreatic head. Pancreatic resection was possible in most patients, and pancreatoduodenectomy was the most common pancreatic resection type.
EN
Posterior interosseous nerve palsy caused by a ganglion is not common and most previous patients were treated with excisional surgery. We treated a case conservatively with needle aspiration using ultrasonography, after a nerve conduction study. A 77-year-old man presented with impaired active finger extension of the left metacarpophalangeal joints. The nerve conduction study revealed conduction block of the left radial nerve near the elbow. Ultrasonography demonstrated a hypoechoic mass anterior to the radial neck compressing the posterior interosseous nerve. Then, needle aspiration of the mass was conducted under ultrasonography. Two months later, active finger extension recovered to normal. A ganglion can be diagnosed with ultrasonography and needle aspiration can be carried out safely under ultrasonography. A nerve conduction study can assess the degree of nerve damage. The combination of ultrasonography and a nerve conduction study can facilitate conservative treatment of needle aspiration for posterior interosseous nerve palsy caused by a ganglion.
PL
Porażenie nerwu międzykostnego tylnego spowodowane obecnością ganglionu nie jest zjawiskiem powszechnym. Po raz pierwszy zostało opisane przez Bowena(1). Większość wcześniejszych przypadków leczono przy pomocy wycięcia chirurgicznego. U naszego pacjenta potwierdziliśmy rozpoznanie i określiliśmy lokalizację ucisku nerwu w badaniu elektromiograficznym. Pacjent został skierowany na leczenie zachowawcze metodą aspiracji igłowej pod kontrolą ultrasonografii (USG). Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/wydawnictwa/volume-17-no-68
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vol. 86
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issue 12
598-600
EN
We reported two cases of the giant mediastinal neurogenic tumors. Patients were women in middle age. In both cases the chest X-ray and CT (computed tomography) demonstrated the huge mass in a pleural cavity without intraspinal invasion. Radical procedures with removal of the giant tumors were performed. The postoperative treatment course was uneventful. The pathology showed schwannoma and neurofibroma. The follow up examination (6-24 months) showed no recurrence of the disease.
EN
Cellular stress responses determine tissue development, homeostasis and pathogenesis. Paracrine signaling, exchange of mechanical stimuli and intercellular transfer of small metabolites via connexin-built gap junctional channels are involved in the cellular stress detection and propagation of stress stimuli in multicellular networks. Cellular stress responses are also regulated through the activity of unpaired connexons (hemichannels) and via the intracellular interference of connexins with the cell cycle and pro-apoptotic machinery. Therefore, connexins are considered as multidirectional transmitters of the "outside-in" and "inside-out" stress signaling that are crucial for tissue homeostasis, regeneration and pathology. In particular, the disturbance of connexin function during the multi-stage process of tumor development leads to abnormal reactions of tumor cells to stress stimuli. In this review, we outline the current knowledge on the multidirectional role of connexins in the detection of stress signals. We also discuss the role of connexin-mediated intercellular transmittance of stress signals in tumour promotion, progression and metastatic cascade. Highlights: 1. Connexins and gap junctions protect cells from the microenvironmental stress and are involved in propagation and intracellular processing of stress signals. 2. The quality and quantity of stress stimuli, which may lead to cell adaptation or death by apoptosis, is determined by intrinsic properties of connexins and the cell phenotype. 3. Connexin deficiency increases the resistance of tumor cells to the "outside-in" stress signaling. 4. The connexin-mediated "inside-out" stress signaling participates in tumor cell invasion during the metastatic cascade.
EN
Introduction: Parotid gland neoplasms represent a heterogenous group of tumors, either benign or malignant. The diagnosis and management of parotid gland tumors is complicated by their relative infrequency and their diverse biologic behavior. Aim: The aim of this study is to investigate the epidemiological characteristics, the recurrence rates and the surgical approach employed for parotid gland tumors in Northern Greece. Material and methods: This is a single-center retrospective study. All patients admitted to the ENT department of “G. Papanikolaou” General Hospital of Thessaloniki from January 2012 to June 2019 with the diagnosis of parotid gland tumor were included in the study. Patients with incomplete charts and patients that underwent revision surgeries were excluded. Chi-squared tests were used to assess the associations between variables. Results: A total of 207 patients with a mean age of 54.97 (range 16–91) were included in the study. Benign neoplasms accounted for 87.9% of the cases. Warthin’s tumor was the most common neoplasm encountered, with an incidence of 46.8%, followed by pleomorphic adenoma (31.9%). There was a higher incidence of parotid gland tumors in males and smokers (P = 0.025, P = 0.001 respectively). The majority of the patients were treated with an extracapsular resection (60.4%) or with a partial superficial parotidectomy (22.6%). In 12 cases (5.7%), there was a recurrence of the lesion. The most common complications encountered were facial nerve injury, Frey’s syndrome and hematoma formation. Conclusions: Parotid gland tumors are typically benign, non-aggressive tumors, more frequently seen in men than women. There is a positive association between smoking and parotid gland tumor development. Comprehensive information regarding recurrence and complication rates is presented.
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2012
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vol. 12
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issue 51
381-401
EN
Most soft tissue mass lesions of the hand are benign. Ganglia are the commonest lesions encountered, followed by giant cell tumors of the tendon sheath. Malignant tumors are rare. Often a specific diagnosis can be achieved on imaging by considering the location and anatomical relations of the lesion within the hand or wrist, and assessing its morphology. Magnetic resonance imaging is an excellent modality for evaluating soft tissue tumors with its multiplanar capability and ability to characterize tissue. Ultrasound plays a complementary role to MRI. It is often the initial modality used for assessing masses as it is cheap and available, and allows reliable differentiation of cystic from solid lesions, along with a real time assessment of vascularity. This review describes the US appearances of the most frequently encountered soft tissue masses of the wrist and hand, correlating the findings with MRI where appropriate.
PL
Większość guzów tkanek miękkich ręki ma łagodny charakter. Do najczęstszych należą gangliony oraz guzy olbrzymiokomórkowe pochewki ścięgnistej. Zmiany złośliwe występują rzadko. W wielu przypadkach ustalenie rozpoznania jest możliwe w badaniach obrazowych na podstawie oceny lokalizacji i morfologii zmian oraz stosunków anatomicznych w obrębie ręki. Rezonans magnetyczny jest doskonałą metodą oceny guzów tkanek miękkich dzięki możliwości wielopłaszczyznowego obrazowania oraz określenia charakteru tkanek. Ultrasonografia stanowi uzupełnienie badania techniką rezonansu magnetycznego. Często jest badaniem pierwszego wyboru z uwagi na niższy koszt i większą dostępność w porównaniu z rezonansem magnetycznym. Pozwala na wiarygodne odróżnienie przestrzeni płynowych od zmian litych oraz na ocenę unaczynienia zmian. Niniejszy artykuł przedstawia obrazy ultrasonograficzne najczęstszych zmian guzowatych tkanek miękkich ręki w korelacji z obrazami rezonansu magnetycznego.
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