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Changes of Cardiac Biomarkers in Ultramarathon Runners

100%

Nosek M., Balko S., Chytry V., Adamec J., Partlova D.

Physical Activity Review

2019

issue 7

89-95

The aim of this study is to examine and evaluate the effects of long-term stress on muscle and heart biomarkers after completing a 100 km ultramarathon. Material and Methods: Venous blood samples of nine runners (average age 38.8±10.2 years), who successfully finished a 100 km ultramarathon at an elevation of 3130 m, were examined before the start, at the finish line immediately after the run, one day after the run and then after 5 and 10 days. Clinical, laboratory, and somatometric data were obtained from all measurements, and biomarkers: aspartate aminotransferase (AST), cortisol (COR), troponin T (cTnT), creatine kinase (CK) and C-reactive protein (CRP). Also, their training experience and ultramarathon experience was monitored. Discovered values were further analyzed with the use of t-test a ω2 (ω2≥0.1), and Spearman's rank correlation coefficient (r) at the significance level of p<0.05. Results: The average finish time of the runners was 13:55:40 (min: 12:12:35, max: 16:52:02). After finishing the ultramarathon, runners showed an average weight loss of 2.4 kg (p<0.05). The results show that hematological changes were caused by physiological stress and long-term physical load. The values of all monitored biomarkers showed a significant exceeding of the normal values immediately after the race in 8 competitors out of 9. The values of cTnT showed an increase of more than 50 % (pre -race: 8.2±2.3, post-race: 34.22±25.9 ng/l, max=98 ng/l). After 24 hours, however, this condition had returned to the normal values for all participants. The results show that the AST hepatic enzymes significantly correlated with the training experience (r=-0.41, p=0.043), the total number of kilometers run per year (r=-0.45, p=0.04) and the achieved finish time (r=0.67, p=0.001). At the same time, athletes who had the best finish time achieved lower CRP values (r=0.74, p=0.023) and cTnT values (r=0.49, p=0.040). The study found that the competitors who had the longest experience with ultramaraton had the lowest cTnT (r=0.44, p=0.050). Conclusion: Long-term physical stress is associated with metabolic and cardiovascular changes. Blood abnormalities found in our study suggest that due to long-lasting extreme stress, heart exhaustion may occur. However, these changes did not last long and after a few days they returned to the normal values for all runners.

The oncological treatment and cardiotoxicity problem – the role of biomarkers

88%

Dudek M., Kałużna-Oleksy M., Migaj J., Lesiak M., Straburzyńska-Migaj E.

OncoReview

2020

vol. 10

issue 4

130-133

Cancer and cardiovascular diseases are a leading causes of morbidity and mortality in developed countries. Cardiological complications of oncological treatment are a significant problem that can be manifested in both permanent and transient cardiac dysfunction including myocardial damage, left ventricular dysfunction, and heart failure, hypertension, ischemia, as well as arrhythmias or QT prolongation, which can be life-threatening. Early detection of cardiotoxicity due to cancer treatment is crucial in the prevention of adverse cardiovascular outcomes in this group of patients. In this review we try to summarize the role of biomarkers in the detection of cardiotoxicity due to cancer treatment.

Mózgowy czynnik natriuretyczny a udar niedokrwienny mózgu

63%

Pyzik M., Gawor R.

Aktualności Neurologiczne

2007

vol. 7

issue 1

45-48

BNP, brain natriuretic peptide, is a member of a family of hormones with natriuretic, diuretic and vasorelaxant activity. It is secreted mostly from the cardiac ventricles, but it is synthetized in the human brain too. Till now measurement of BNP has been valuable in the rapid diagnosis of heart failure. Reports of changes in BNP content in cerebrovascular diseases suggest that BNP plays a role in pathogenesis and pathophysiology of ischemic stroke. BNP is elevated in nearly two thirds of acute stroke patients. This rise is caused inter alia 1) by the sympathetic system activation, which may have toxic effect on the myocardium, leading to myocardial dysfunction and increased secretion of BNP from the damaged heart, and 2) by increased production of BNP by the damaged part of brain. The attempts to find correlation between circulating NT-proBNP concentration and stroke topography, infarct size or severity of neurological deficit do not give unequivocal results. The same applies to prognostic value of BNP concentration during ischemic stroke. Despite the contradictory findings, it is worth continuing this research, because there is an association between cardiac failure and poor prognosis in acute cerebrovascular diseases. Early prognosis of heart failure in ischemic stroke may be useful in the selection of an adequate therapy and may improve prognosis of acute stroke patients.

BNP, czyli mózgowy czynnik natriuretyczny, należy do rodziny hormonów o działaniu natriuretycznym, diuretycznym i wazodylatacyjnym. Jest uwalniany przede wszystkim przez tkankę mięśniową komór serca, ale syntetyzuje go również ludzki mózg. Dotychczas oznaczanie BNP było użyteczne w szybkiej diagnostyce niewydolności mięśnia sercowego. Doniesienia o zmianach stężenia tego czynnika w chorobach naczyniowych mózgu sugerują jego udział także w patogenezie i patofizjologii udaru niedokrwiennego mózgu. Stężenie BNP wzrasta u blisko 2/3 pacjentów w ostrej fazie niedokrwienia. Przyczyną tego wzrostu jest m.in. 1) aktywacja układu współczulnego, która wywołuje toksyczny efekt na miokardium, prowadząc do zaburzeń funkcji serca i uwalniania BNP, oraz 2) zwiększona produkcja tego czynnika w uszkodzonych częściach mózgu. Próby powiązania wzrostu stężenia hormonu natriuretycznego typu B z różnymi parametrami udaru niedokrwiennego (topografia, wielkość, stopień deficytu neurologicznego) nie przynoszą jednoznacznych wyników. Brak również zgody w określeniu wartości prognostycznej BNP w przebiegu niedokrwienia mózgu. Mimo sprzecznych doniesień, należy kontynuować te badania, m.in. dlatego, że niewydolność serca ma związek ze złym rokowaniem w przebiegu ostrych incydentów naczyniowych OUN. Jej wczesne rozpoznanie w udarze niedokrwiennym mózgu może ułatwić szybkie wdrożeniu adekwatnej farmakoterapii i poprawić rokowanie pacjentów z udarem.

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1 Aktualności Neurologiczne

1 OncoReview

1 Physical Activity Review

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1 Adamec J.

1 Balko S.

1 Chytry V.

1 Dudek M.

1 Gawor R.

1 Kałużna-Oleksy M.

1 Lesiak M.

1 Migaj J.

1 Nosek M.

1 Partlova D.

1 Pyzik M.

1 Straburzyńska-Migaj E.

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Changes of Cardiac Biomarkers in Ultramarathon Runners

The oncological treatment and cardiotoxicity problem – the role of biomarkers

Mózgowy czynnik natriuretyczny a udar niedokrwienny mózgu