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The lateralizing and localizing value of peri-ictal cough in epileptic seizures

100%

Korkmaz B., Erşen G., Delil Ş., Özkara Ç., Yeni S. N.

vol. 21

issue 2

71-77

Introduction. Coughing may be observed as an epiphenomenon during or after epileptic seizures. Aim. In this paper we discuss the lateralization and localization value of cough as an epileptic peri/post ictal semiological phenomenon. Material and Methods. Seven patients presenting cough as a part of their symptomatology are presented. We will discuss cough in the context of these seven patients. Results. Six out of these seven patients were multidrug resistant temporal lobe epilepsy patients, all were right handed. They were all examined for possible epilepsy surgery and four underwent surgery with complete seizure freedom. We do not have certain evidence for lateralization in one patient with hot water epilepsy though déjà vu as an initial symptom in this patient implies a temporal lobe onset. The seven other patients had temporal lobe epilepsy. Among the patients who had surgery, three had left sided and one had right sided temporal lobe surgery with consequent seizure freedom. Conclusion. Referring to the argument in the literature, with our small patient sample, we might conclude that cough has significant value in localizing seizures to the temporal lobe but overall these limited data do not suggest a lateralizing value.

Neurobiological and clinical predictors of remission and antiepileptic treatment efficacy in partial epilepsies

72%

Kalinin V. V., Zemlyanaya A. A., Zheleznova E. V., Sokolova L. V.

vol. 21

issue 1

15-25

Introduction.The current knowledge of significance of some neurobiological and clinical variables in the prediction of remission length and seizures reduction in partial epilepsies remains sparse and even controversial. Aim. The current study has been carried out in order to evaluate the possible relationship between epilepsy forms, gender, focus lateralization and handedness with therapeutic remission and seizures reduction during antiepileptic treatment in persons with partial forms of epilepsy. Material and methods. One hundred and eight patients were studied. Handedness was evaluated using the Annett's scale. Focus lateralization was detected by use of the EEG. Of the patients studied temporal lobe epilepsy (TLE) was diagnosed in 61 cases and frontal lobe epilepsy (FLE) in 47 cases. There were 44 men and 64 women, of which 83 were right-handed and 25 were left-handed. A left-sided focus was detected in 59 persons whilst a right-sided focus was noted in 49 persons. MANOVA was used for the analysis of interrelationship between four nominal fixed factors (epilepsy forms, gender, handedness, and focus laterality) and dependent variables of therapeutic remission and percentage seizures reduction. Results. A favorable prognostic significance of FLE vs TLE was observed. In contrast gender, handedness, and focus laterality had no influence on the dependent variables when analyzed separately. However, when two, three and four independent variables were combined an influence on the dependent variables was observed; and some combinations may be used for prediction purposes of therapeutic remission and percentage in seizure reduction. The FLE in the men with the right-handedness and the left focus (FLE • M • Rh • LF) resulted in the maximal length of therapeutic remission and maximal seizures reduction, while the other combinations have resulted in less favorable treatment results. The TLE • M • Rh • RF and TLE • M • Lh • LF were the worst combinations for the remission length and TLE • Fe • Lh • LF for the seizures reduction. Conclusions. The current study revealed the significance of combinations of some neurobiological and clinical variables in prediction of therapeutic remission and percent of seizures reduction irrespective of used antiepileptic drugs. These results may be used so as to aid patient selection before drug treatment in order to form the homogenous groups of persons.

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2 Journal of Epileptology

2 2013

1 Delil Ş.

1 Erşen G.

1 Kalinin V. V.

1 Korkmaz B.

1 Sokolova L. V.

1 Yeni S. N.

1 Zemlyanaya A. A.

1 Zheleznova E. V.

1 Özkara Ç.

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The lateralizing and localizing value of peri-ictal cough in epileptic seizures

Neurobiological and clinical predictors of remission and antiepileptic treatment efficacy in partial epilepsies