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Soft tissue angiofibroma on the ridge of the maxilla: a rare case report

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VahedI M., Fathi S., Hayati Z., Hashemi A. H.
Polski Przegląd Otorynolaryngologiczny
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2015
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vol. 4(4)
49-52
EN
Soft tissue angiofibroma is a benign vascular neoplasm that occurs predominantly in the nasopharynx area of adolescent males. Primary extranasopharyngeal location without involvement of the nasopharynx is unusual and tends to occur at a later age. Extra nasopharyngeal angiofibromas are clinically different from juvenile nasopharyngeal angiofibromas. According to a vast literature search, presenting angiofibroma in the oral cavity is extremely rare. Extranasopharyngeal angiofibroma arising from the ridge of the maxilla in the oral cavity has not been reported up to now and this case is probably the first to be reported.
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Soft tissue sarcomas of the head and neck region: clinical and histopathological study of 39 patients

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Markowski J., Długosz-Karbowska A., Ciupińska M., Smółka W., Dobrosz Z., Ślaska-Kaspera A., Lesniewska-Skowerska O., Likus W., Mazurek K.
Polish Journal of Otolaryngology
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2024
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vol. 78
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issue 4
21-28
EN
Introduction: Soft tissue sarcomas (STS) constitute about 1–2% of all malignant tumors, with approximately 10% of them located in the head and neck region. Aim: The aim of this study was the assessment of treatment efficiency in head and neck STS of adult patients of the ENT Department of Medical University of Silesia, treated surgically in the period 1980–2023. Materials and methods: Retrospective analysis of 39 patients with the diagnosis of head and neck STS. Results: Histopathological examination showed 21 different types of STS located most commonly in: paranasal sinuses (13 cases), orbital cavity (6 cases), nasal cavity (3 cases), and larynx (3 cases). Other locations: parapharyngeal space, parotid gland, nasal septum, bridge of the nose, soft and hard palate, mandibular mucosa, tongue, auricle, palatine tonsil, and cheek. All those patients underwent chemoradiation as postoperative treatment. Radical surgical procedure was achieved in 32 patients (82%). However, in 11 patients (28%), microscopic examination did not confirm radical resection (R1 – PSM – positive surgical margin). In 7 patients (18%), the surgical procedure turned out to be not radical on macroscopic examination (R2). Dissemination of neoplasms (distant metastases) was found in 7 patients (18%). Five-year survival time without local recurrence was achieved in 25 patients (64%). The most frequent reason for unsuccessful interventions was local recurrence noted in 18 patients (46%), while distant metastases occurred in 9 patients (23%). Conclusions: The basic procedure in the treatment of STS is radical surgery combined with preoperative or postoperative radiotherapy and/or chemotherapy and, in case of a metastasis, surgical removal thereof. Despite the fact that sarcomas are rare tumors, they remain a challenge for head and neck surgery. Recurrence rates and mortality remain high due to the high degree of malignancy.
3
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Angiogenic Effect of Bioactive Borate Glass Microfibers and Beads in the Hairless Mouse

75%
Watters R. J., Brown R. F., Day D. E.
Biomedical glasses
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2015
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vol. 1
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issue 1
EN
The purpose of this project was to investigate the angiogenic mechanism of bioactive borate glass for soft tissue repair in a ‘hairless’ SKH1 mouse model. Subcutaneous microvascular responses to bioactive glass microfibers (45S5, 13-93B3, and 13-93B3Cu) and bioactive glass beads (13-93, 13-93B3, and 13-93B3Cu) were assessed via: noninvasive imaging of skin microvasculature; histomorphometry of microvascular densities; and quantitative PCR measurements of mRNA expression of VEGF and FGF-2 cytokines. Live imaging via dorsal skin windows showed the formation at twoweeks of a halo-like structure infused with microvessels surrounding implanted boratebased 13-93B3 and 13-93B3Cu glass beads, a response not observed with silicate-based 13-93 glass beads. Quantitative histomorphometry of tissues implanted with plugs of 45S5, 13-93B3, and 13-93B3Cu glass microfibers revealed microvascular densities that were 1.6-, 2.3-, and 2.7-times higher, respectively, than the sham control valueswhereas 13-93, 13-93B3, and 13-93B3Cu glass beads caused the microvascular density to increase 1.3-, 1.6-, and 2.5-fold, respectively, relative to sham controls. Quantitative PCR measurements indicate a marginally significant increased expression of VEGF mRNA in tissues with 13-93B3Cu glass beads, an outcome that supported the hypothesis that copper-doped borate glass could promote VEGF expression followed by angiogenesis for enhanced wound healing.
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