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1

Influenza viruses resistant to neuraminidase inhibitors

100%

Nitsch-Osuch A., Brydak L.

Acta Biochimica Polonica

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2014

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vol. 61

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issue 3

505-508

EN

Neuraminidase inhibitors (NAIs) are antiviral drugs for treatment and prophylaxis of influenza. By blocking the activity of the enzyme neuraminidase, NAIs prevent new viral particles from being released. The increasing use of NAIs brings into focus the risk of drug resistance arising to the class. There are three levels of antiviral resistance according to the way that resistance can be detected or inferred: genotypic, phenotypic and clinical resistance. For many years seasonal influenza viruses resistance to NAIs was low (0.33%). Recently, there has been described an increasing number of resistant seasonal influenza strains to oseltamivir (2% in adults, 5-18% in children). In 2007 there were published data describing 14% resistant to oseltamivir strains of influenza A/H1N1/ in Europe. Approximately 0.5-1.0% of influenza A/H1N1/pdm09 isolates are currently resistant to oseltamivir. The established markers of the resistance to oseltamivir were found in 2.4% of human and 0.8% of avian isolates of influenza A/H5N1/. It has been not observed a cross resistance among oseltamivir and zanamivir. NAIs resistance in influenza viruses is relative and despite its presence patients with resistant viruses may still benefit from receiving these antivirals. The response to treatment with antivirals remains the most important proof of antiviral effectiveness. The rational use of NAIs is essential to preserve the best choice for treatment and prophylaxis of seasonal, avian and pandemic influenza.

2

Design of hollow section overlap joints with reinforcing rib plate. Joint resistance

100%

Bródka J.

Archives of Civil Engineering

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2015

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issue 1

3

Comparison of antibiotic resistance and virulence between biofilm-producing and non-producing clinical isolates of Enterococcus faecium

100%

Sieńko A., Wieczorek P., Majewski P., Ojdana D., Wieczorek A., Olszańska D., Tryniszewska E.

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issue 4

859-866

EN

An increase in the antibiotic resistance among Enterococcus faecium strains has been observed worldwide. Moreover, this bacteria has the ability to produce several virulence factors and to form biofilm that plays an important role in human infections. This study was designed to compare the antibiotic resistance and the prevalence of genes encoding surface protein (esp), aggregation substance (as), surface adhesin (efaA), collagen adhesin (ace), gelatinase (gelE), and hialuronidase (hyl) between biofilm-producing and non-producing E. faecium strains. Therefore, ninety E. faecium clinical isolates were tested for biofilm-forming ability, and then were assigned to two groups: biofilm-positive (BIO+, n =70) and biofilm-negative (BIO-, n = 20). Comparison of these groups showed that BIO+ isolates were resistant to β-lactams, whereas 10% of BIO- strains were susceptible to ampicillin (statistically significant difference, p = 0.007) and 5% to imipenem. Linezolid and tigecycline were the only antibiotics active against all tested isolates. Analysis of the virulence factors revealed that ace, efaA, and gelE genes occurred more frequently in BIO- strains (ace in 50% BIO+ vs. 75% BIO-; efaA 44.3% vs. 85%; gelE 2.9% vs. 15%, respectively), while hyl gene appeared more frequently in BIO+ isolates (87.1% BIO+ vs. 65% BIO-). These differences were significant (p < 0.05). We concluded that BIO+ strains were more resistant to antibiotics than BIO- strains, but interestingly, BIO- isolates were characterized by possession of higher virulence capabilities.

4

The Presence of Metals and Antibiotics Resistant Bacteria in Arable Manure Soils

100%

Erdem B., Dayangaç A., Şahin İ.

Acta Physica Polonica A

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2017

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vol. 132

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issue 3

570-571

EN

Heavy metals and antibiotics resistance are intense public interest owing to their pollution in the environment and potential deleterious effects on human health. A total of 15 isolates of Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa and Escherichia coli (50 manure garden soils) were tested for their resistance against certain heavy metals and antibiotics. Minimum inhibitory concentrations of Pb²⁺, Co²⁺, Cu²⁺, and Zn²⁺ for each isolate were also determined. B. subtilis, B. cereus, P. aeruginosa and E. coli exhibited high tolerance to minimum inhibitory concentrations of 3,200 μg/ml for Pb²⁺, 400 μg/ml for Cu²⁺ and Co²⁺, and 100 μg/ml for Zn²⁺ in agar plates. All the isolates were highly resistant to lead and they showed 100% growth in 3,200 μg/ml concentration. It was observed that all isolates were resistant to a wide range of antibiotics namely clindamycin, ceftazidime, aztreonam and vancomycin.

5

Moderate resistance to tomato leaf curl virus among commercial tomato cultivars in northern Nigeria

88%

Alegbejo M., Banwo O.

Journal of Plant Protection Research

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2006

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vol. 46

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issue 3

6

Antimicrobial susceptibility of Salmonella spp.strains isolated from free-living birds

88%

Krawiec M., Rusiecki S., Kuczkowski M., Wieliczko A.

Polish Journal of Veterinary Sciences

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2017

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issue 4

7

Therapeutic effects of Cucumis metuliferus fruits on avian viruses

88%

Olamilekan A. R.

World News of Natural Sciences

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2021

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vol. 35

68-82

EN

Poverty is the major restraint of people to modern medicine in the developing world. This brought about therapeutic usage of medicinal plants which can be traced back to history as different cultures utilize plants and plant products from ancient time for preventing and treating of diseases. These People in the developing countries or rural areas solely depend on traditional medicine for their primary health care, in which they majorly use plants or their active principles. Upsurge resistance of avian viruses to commercial drugs is both developed and developing countries problem which imposed a search for new avian antiviral substances from other sources like medicinal plants. This led to the discovery of Cucumis metuliferus E. Mey. ex Naudin fruit which has been verified by local farmers and scientific researchers to cure various diseases and conditions including avian viruses like Newcastle Disease Virus (NDV), Infectious Bursal Disease Virus (IBDV), avian influenza and Hepatitis B Virus. This review is aimed at revealing the avian virus diseases that are treated with the Cucumis metuliferus E. Mey. ex Naudin, fruit and phytochemical constituents responsible for this antiviral activities.

8

In vitro activity of oxazaphosphorines in childhood acute leukemia: Preliminary report.

88%

Styczyński J., Wysocki M., Dębski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sońta-Jakimczyk D., Chybicka A.

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vol. 49

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issue 1

221-225

EN

Glufosfamide (β-D-glucosyl-ifosfamide mustard) is a new agent for cancer chemotherapy. Its pharmacology is similar to commonly used oxazaphosphorines, but it does not require activation by hepatic cytochrome P-450 and preclinically demonstrates lower nephrotoxicity and myelosuppression than ifosfamide. The aim of the study was a comparison of the drug resistance profiles of glufosfamide and other oxazaphosphorines in childhood acute leukemias. Leukemic cells, taken from children with ALL on diagnosis (n = 41), ALL on relapse (n = 12) and AML on diagnosis (n= 13) were analyzed by means of the MTT assay. The following drugs were tested: glufosfamide (GLU), 4-HOO-ifosfamide (IFO), 4-HOO-cyclophosphamide (CYC) and mafosfamide cyclohexylamine salt (MAF). In the group of initial ALL samples median cytotoxicity values for GLU, IFO, CYC and MAF were 15.5, 33.8, 15.7 and 7.8 μM, respectively. In comparison with initial ALL samples, the relative resistance for GLU and IFO in relapsed ALL samples was 1.9 (p = 0.049) and 1.3 (ns), and in initial AML samples 31 (p < 0.001) and 5 (p = 0.001), respectively. All oxazaphosphorines presented highly significant cross-resistance. Glufosfamide presented high activity against lymphoblasts both on diagnosis and on relapse.

9

Resistance risk assessment: realized heritability, cross resistance and resistance stability of acetamiprid in the cotton aphid, Aphis gossypii Glover (Homoptera: Aphididae)

88%

Mokbel E.-S. M. S.

Journal of Plant Protection Research

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2018

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vol. 58

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issue 4

10

Appropriate Loads for Peak-Power During Resisted Sprinting on a Non-Motorized Treadmill

88%

Andre M. J., Fry A. C., Lane M. T.

Journal of Human Kinetics

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2013

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vol. 38

161-167

EN

The purpose of this study was to determine the load which allows the highest peak power for resisted sprinting on a non-motorized treadmill and to determine if other variables are related to individual differences. Thirty college students were tested for vertical jump, vertical jump peak and mean power, 10 m sprint, 20 m sprint, leg press 1 RM, leg press 1 RM relative to body weight, leg press 1 RM relative to lean body mass, leg press 1 RM power, and leg press power at 80% of 1 RM. Participants performed eight resisted sprints on a non-motorized treadmill, with increasing relative loads expressed as percent of body weight. Sprint peak power was measured for each load. Pearson correlations were used to determine if relationships between the sprint peak power load and the other variables were significant. The sprint peak power load had a mode of 35% with 73% of all participants having a relative sprint peak power load between 25-35%. Significant correlations occurred between sprint peak power load and body weight, lean body mass, vertical jump peak and mean power, leg press 1 RM, leg press 1 RM relative to lean body mass, leg press 1 RM power, and leg press power at 80% of 1 RM (r = 0.44, 0.43, 0.39, 0.37, 0.47, 0.39, 0.46, and 0.47, respectively). Larger, stronger, more powerful athletes produced peak power at a higher relative load during resisted sprinting on a nonmotorized treadmill.

11

Resistance of some sesame (Sesamum indicum L.) collections against root rot disease (Rhizoctonia solani Kühn) under field conditions

75%

Wahid O. A. R. A., El-Bramawy M. A. E.-H. S. A.

Journal of Plant Protection Research

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2007

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vol. 47

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issue 3

12

Evaluation of locally available tomato varieties and introductions for resistance to bacterial speck and bacterial spot diseases in Tanzania

75%

Shenge K. C., Mabagala R. B., Mortensen C. N.

Journal of Plant Protection Research

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2007

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vol. 47

|

issue 2

13

Validation of relationship between milk resistance and daily yield of dairy cows

75%

Wojciechowska B., Burmańczuk A., Grabowski T., Kowalski C., Hola P.

Polish Journal of Veterinary Sciences

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2017

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issue 4

14

In-situ automatic observations of ice thickness of seas

75%

Dou Y., Chang X.

Metrology and Measurement Systems

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2012

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issue 3

15

Eyespot resistance of winter wheat breeding lines evaluated with marker-assisted selection and inoculation tests at the seedling and adult plant stages

75%

Majka M., Kwiatek M., Korbas M., Danielewicz J., Gawłowska M., Góral T., Wiśniewska H.

Journal of Plant Protection Research

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2018

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vol. 58

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issue 4

16

Occurrence and Antibiotic Resistance Profile of Bacteria Isolated from Freshly Sliced Ready to Eat Fruits Sold Across Major Retail Outlets within Owerri Metropolis

75%

Dike K. S.

|

EN

In recent years, there has been a substantial rise in the consumption of sliced ready-to-eat fruits sold across numerous retail outlets in Nigeria. This is because of their high accessibility, convenience, and, most significantly, their lower cost than whole fruits. Nevertheless, these food items have continually acted as carriers for human diseases on a global scale. This study evaluated the occurrence and antibiogram of bacteria from ready-to-eat sliced fruits sold across major retail outlets in the Owerri metropolis. One hundred and fifty samples comprising oranges, watermelons, pineapples, and paw-paws were analysed using standard microbiological techniques. Bacteria isolates were identified using cultural, biochemical, and molecular methods. Antibiotic sensitivity was performed using the Kirby-Bauer diffusion technique. Results showed that orange samples had the highest total viable count (2.50 log cfu/g), total coliform count (2.70 log cfu/g), and faecal coliform count (2.05 log cfu/g), respectively. Staphylococcus aureus predominated in the fruit samples with a percentage occurrence of 29.4%. Isolates exhibited different resistance levels, with Staphylococcus aureus and Bacillus spp showing a high resistance against Gentamycin and ofloxacin. These findings demand further investigation due to the possible health risks of coliform bacteria, faecal coliform and antibiotic resistance. Therefore, monitoring and implementing food safety standards is necessary to protect consumers.

17

Antimicrobial studies and phytochemical analysis of the fruits and leaves of Cnestis ferruginea

75%

Ebana R. U. B., Edet U. O., Atang D. E., Iyere L. A.

World News of Natural Sciences

|

2019

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vol. 25

188-198

EN

Few studies have shown that Cnestis ferruginea possess some therapeutic properties. The present study was aimed screening the extracts of the fruits and leaves of Cnestis ferruginea for phytochemicals using crude screening and gas chromatography-mass spectrophotometer (GC-MS) methods, and also antimicrobial activity against clinical isolates. Preparation of the extracts (aqueous and ethanolic), identification of isolates, and antimicrobial sensitivity were done using previously reported standard methodologies. Replicate readings for the antimicrobial sensitivity were analysed using analysis of variance at 95% level of significance. The result of the crude qualitative screening revealed the presence of phenol, terpenes, alkaloids, saponins, tannin and polyphenol in various amounts in both the leaves and fruits. Quantitative analysis using GC-MS revealed a total of 14 similar phytochemicals each in the leaves and fruits of the study plant in varying amounts. In the fruits, phenol had the highest concentration of 15.01%, followed by terpenes (10.64%), alkaloid (5.43%), and tannins (5.16%). Others were anthocyanins, phytate, phytosterol, steroids, saponins, cardiac glycosides, oxalate, flavonoids, cyanogenic glycosides and coumarin with concentrations that ranged from to 0.01- 4.21%. On the other hand, in the leaves, alkaloids had the highest concentration of 31.62%, followed by phenol (20.59%), phytate (15.18%), and tannin (12.34%). Others include were flavonoid, terpenes, phytosterol, cardiac glycosides, saponins, cyanogenic glycosides, oxalate, anthocyanins, steroids and coumarin with concentrations that ranged from 0.16-8.45%. The isolates were identified as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Proteus spp. The results of the antimicrobial sensitivity revealed varying zones of inhibitions; however, it increased as the concentration of the extract increased. The observed highest zones of inhibitions were 33.86 mm for the fruit ethanolic extract and 30.56 mm for the aqueous extract of the leaves against Proteus and Staphylococcus aureus, respectively.

18

Survey of anthelmintic resistance in a Romanian horse stud using three different methods

75%

Dărăbuş G., Badea C., Oprescu I., Morariu S., Mederle N., Ilie M., Suici T., Imre M., Dărăbuş G., Badea C., Oprescu I., Morariu S., Mederle N., Ilie M., Suici T., Imre M.

Polish Journal of Veterinary Sciences

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2021

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vol. 24

|

issue 1

19

Variability of statistical parameters of resistance for reinforced concrete columns with circular cross-section

75%

Lutomirski T. A., Lutomirska M., Lutomirski T. A., Lutomirska M.

Archives of Civil Engineering

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2021

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vol. 67

|

issue 2

20

Phytotoxicity and efficacy of chlorsulfuron in winter wheat

63%

Marczewska K.

Journal of Plant Protection Research

|

2006

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vol. 46

|

issue 4

Refine search results

Influenza viruses resistant to neuraminidase inhibitors

Design of hollow section overlap joints with reinforcing rib plate. Joint resistance

Comparison of antibiotic resistance and virulence between biofilm-producing and non-producing clinical isolates of Enterococcus faecium

The Presence of Metals and Antibiotics Resistant Bacteria in Arable Manure Soils

Moderate resistance to tomato leaf curl virus among commercial tomato cultivars in northern Nigeria

Antimicrobial susceptibility of Salmonella spp.strains isolated from free-living birds

Therapeutic effects of Cucumis metuliferus fruits on avian viruses

In vitro activity of oxazaphosphorines in childhood acute leukemia: Preliminary report.

Resistance risk assessment: realized heritability, cross resistance and resistance stability of acetamiprid in the cotton aphid, Aphis gossypii Glover (Homoptera: Aphididae)

Appropriate Loads for Peak-Power During Resisted Sprinting on a Non-Motorized Treadmill

Resistance of some sesame (Sesamum indicum L.) collections against root rot disease (Rhizoctonia solani Kühn) under field conditions

Evaluation of locally available tomato varieties and introductions for resistance to bacterial speck and bacterial spot diseases in Tanzania

Validation of relationship between milk resistance and daily yield of dairy cows

In-situ automatic observations of ice thickness of seas

Eyespot resistance of winter wheat breeding lines evaluated with marker-assisted selection and inoculation tests at the seedling and adult plant stages

Occurrence and Antibiotic Resistance Profile of Bacteria Isolated from Freshly Sliced Ready to Eat Fruits Sold Across Major Retail Outlets within Owerri Metropolis

Antimicrobial studies and phytochemical analysis of the fruits and leaves of Cnestis ferruginea

Survey of anthelmintic resistance in a Romanian horse stud using three different methods

Variability of statistical parameters of resistance for reinforced concrete columns with circular cross-section

Phytotoxicity and efficacy of chlorsulfuron in winter wheat