Search results

1

Cardiac endothelial cells isolated from mouse heart - a novel model for radiobiology

100%

Jelonek K., Walaszczyk A., Gabryś D., Pietrowska M., Kanthou C., Widłak P.

Acta Biochimica Polonica

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2011

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vol. 58

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issue 3

397-404

EN

Cardiovascular disease is recognized as an important clinical problem in radiotherapy and radiation protection. However, only few radiobiological models relevant for assessment of cardiotoxic effects of ionizing radiation are available. Here we describe the isolation of mouse primary cardiac endothelial cells, a possible target for cardiotoxic effects of radiation. Cells isolated from hearts of juvenile mice were cultured and irradiated in vitro. In addition, cells isolated from hearts of locally irradiated adult animals (up to 6 days after irradiation) were tested. A dose-dependent formation of histone γH2A.X foci was observed after in vitro irradiation of cultured cells. However, such cells were resistant to radiation-induced apoptosis. Increased levels of actin stress fibres were observed in the cytoplasm of cardiac endothelial cells irradiated in vitro or isolated from irradiated animals. A high dose of 16 Gy did not increase permeability to Dextran in monolayers formed by endothelial cells. Up-regulated expression of Vcam1, Sele and Hsp70i genes was detected after irradiation in vitro and in cells isolated few days after irradiation in vivo. The increased level of actin stress fibres and enhanced expression of stress-response genes in irradiated endothelial cells are potentially involved in cardiotoxic effects of ionizing radiation.

2

Radiative spectra of thermal electromagnetic noise induced by planar realistic dielectrics

100%

Dorofeyev I., Fuchs H., Sobakinskaya K.

Open Physics

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2005

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vol. 3

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issue 3

351-375

EN

Spectral characteristics of stochastic fields and their spatial derivatives in various planar structures composed by lossy materials described by realistic dielectric functions are numerically calculated based on solutions to the problems of multipolar electromagnetic fields in a plane layered geometry. A displacement of the maximum of the spectral power densities for spatial derivatives of fluctuating fields to the high-frequency domain, a resonant increase in the density of states of the fluctuating fields at the frequencies of interface excitations and interference modes for the radiative part of the spectra, the influence of geometry on the density of states, and other peculiarities are found by numerical calculations and graphically demonstrated. Interpretations of the above effects are provided.

3

Radon Measurements in Groundwater Mines in La Palma and El Hierro, Canary Islands (Spain)

86%

Santamarta J. C., Gutiérrez L. E. H., Rodríguez Martín J., Pérez L., Lario Bascones R. J., Moro Á. M. G., Cruz Pérez N., Santamarta J. C., Gutiérrez L. E. H., Rodríguez Martín J., Pérez L., Lario Bascones R. J., Moro Á. M. G., Cruz Pérez N.

Archives of Mining Sciences

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2020

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vol. 65

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issue 4

4

Radiation of Sound Waves by a Semi-Infinite Duct with Outer Lining and Perforated End

86%

Tiryakioglu B., Tiryakioglu B.

Archives of Acoustics

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2020

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vol. 45

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issue 1

5

Radiation Degradation of Bipolar Transistor Current Gain

86%

Miskiewicz S., Komarov A., Komarov F., Zayats G., Soroka S.

Acta Physica Polonica A

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2017

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vol. 132

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issue 2

288-290

EN

Spatial distribution of nonequilibrium minority charge carriers in bipolar transistors before and during the radiation exposure is described. Radiation-induced changes in the input and output characteristics and the current gain under the ⁶⁰Co 1.2 MeV γ -rays were calculated. It was shown that the collector current and current gain steadily fall due to irradiation in the considered range in the dose range 0-7×10⁵ rad. The simulation results correlate well with the experimental data obtained at the Research and Production Corporation "Integral".

6

The prognostic significance of histology and treatment modality in stage IB1 squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the uterine cervix: SEER study 2004–2008

86%

Herskovic A., Yan W., Christos P., Ye J. C., Nori D., Ravi A.

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issue 2

78-84

EN

Objective: To determine the significance of histology and treatment modality on overall survival and cause-specific survival in stage IB1 cervical carcinoma. Methods: Cases of stage IB1 squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the uterine cervix managed with either radical hysterectomy, definitive radiation therapy which may include external beam radiation therapy and/or vaginal brachytherapy, or total abdominal hysterectomy with adjuvant radiation therapy which may include external beam radiation therapy plus/minus vaginal brachytherapy were abstracted from the SEER database (2004–2008). Cause-specific survival was calculated using Kaplan–Meier, log-rank, and multivariable Cox regression analyses. Results: Five-year cause-specific survival for squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma were 94.4%, 97.3%, and 85.7%, respectively (p = 0.001 by log-rank test). On multivariable Cox regression analysis, patients with squamous cell carcinoma were not more likely to die of cervical cancer than patients with adenocarcinoma (hazard ratio = 1.12, 95% confidence interval = 0.53–2.39); but patients with adenosquamous cell carcinoma were more likely to die of cervical cancer than patients with adenocarcinoma (hazard ratio = 3.65, 95% confidence interval = 1.41–9.44). Five-year cause-specific survival was 96.9%, 80.0%, and 92.4% for patients receiving radical hysterectomy, definitive radiation therapy, and total abdominal hysterectomy plus radiation therapy, respectively (p < 0.0001 by log-rank test). On multivariable Cox regression analysis, patients who received definitive radiation therapy and patients who received total abdominal hysterectomy plus radiation therapy were more likely to die of cervical cancer than patients who received radical hysterectomy. Conclusion: In patients with stage IB1 cervical cancer, on multivariable Cox regression analysis, patients with squamous cell carcinoma were not more likely to die of cervical cancer than patients with adenocarcinoma; patients with adenosquamous cell carcinoma were more likely to die of cervical cancer than patients with adenocarcinoma. Patients who received either definitive radiation therapy or total abdominal hysterectomy plus radiation therapy were more likely to die of cervical cancer than patients who received radical hysterectomy.

PL

Cel pracy: Określenie wpływu histologii nowotworu oraz metody leczenia na całkowity czas przeżycia i czas przeżycia swoistego w przypadku raka szyjki macicy w stadium IB1. Metody: Analizowano zawarte w rejestrze SEER, obejmujące lata 2004–2008, przypadki raka płaskonabłonkowego, gruczolakoraka i raka gruczołowo-płaskonabłonkowego szyjki macicy w stadium IB1, w których zastosowano radykalną histerektomię, radykalną radioterapię, w tym napromienianie wiązką zewnętrzną i/lub brachyterapię dopochwową, bądź całkowitą histerektomię brzuszną z radioterapią adiuwantową, w tym napromienianie wiązką zewnętrzną z brachyterapią dopochwową lub bez niej. Czas przeżycia swoistego obliczono, wykorzystując analizę Kaplana–Meiera, test log-rank oraz wieloczynnikową analizę regresji Coxa. Wyniki: Pięcioletnie przeżycie swoiste w przypadku raka płaskonabłonkowego, gruczolakoraka oraz raka gruczołowo-płaskonabłonkowego wynosiło odpowiednio 94,4%, 97,3% i 85,7% (p = 0,001 wg testu log-rank). Wieloczynnikowa analiza regresji Coxa wykazała, że prawdopodobieństwo zgonu z powodu raka szyjki macicy u pacjentek z rakiem płaskonabłonkowym nie było wyższe niż u pacjentek z gruczolakorakiem (współczynnik ryzyka = 1,12; przedział ufności 95% = 0,53–2,39). Z kolei u pacjentek z rakiem gruczołowo-płaskonabłonkowym prawdopodobieństwo zgonu z powodu tego nowotworu było wyższe niż u pacjentek z gruczolakorakiem (współczynnik ryzyka = 3,65, przedział ufności 95% = 1,41–9,44). Pięcioletnie przeżycie swoiste wynosiło 96,9%, 80,0% i 92,4% u chorych, które zostały poddane odpowiednio radykalnej histerektomii, radykalnej radioterapii oraz całkowitej histerektomii brzusznej z radioterapią (p < 0,0001 wg testu log-rank). Wieloczynnikowa analiza regresji Coxa wykazała większe prawdopodobieństwo zgonu z powodu raka szyjki macicy u pacjentek, które zostały poddane radykalnej radioterapii, oraz tych, które przeszły zabieg całkowitej histerektomii brzusznej z radioterapią, w porównaniu z chorymi, które poddano radykalnej histerektomii. Wniosek: U chorych na raka szyjki macicy w stadium IB1 wieloczynnikowa analiza regresji Coxa wykazała, że prawdopodobieństwo zgonu z powodu raka szyjki macicy u pacjentek z rakiem płaskonabłonkowym nie było większe niż u pacjentek z gruczolakorakiem, z kolei u chorych z rakiem gruczołowopłaskonabłonkowym było wyższe niż u pacjentek z gruczolakorakiem. U pacjentek, które zostały poddane radykalnej radioterapii lub przeszły zabieg całkowitej histerektomii brzusznej z radioterapią, prawdopodobieństwo zgonu z powodu raka szyjki macicy było większe niż u chorych, które poddano radykalnej histerektomii.

7

Role of T-lymphocytes in Radiation-Impaired Wound Healing

86%

Schäffer M., Stülten C., Viebahn R.

Polish Journal of Surgery

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2007

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vol. 79

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issue 4

312-318

EN

Radiation impairs healing, although the underlying mechanisms are not clearly defined. T-lymphocytes have been shown to be critical for wound healing. We hypothesized that radiation-impaired healing may affect different subtypes of T cells.The aim of the study. We studied the effect of local electron irradiation on standard parameters of dermal wound healing in rats and correlated the outcome of healing with the expression of different lymphocyte subtypes in the wound.Material and methods. Groups of 10 rats were irradiated using single dose 12 or 24 Gray electron radiation at the dorsal skin. Control rats were sham-irradiated. On day 5, a skin incision in the irradiated area was performed and polyvinyl alcohol sponges were inserted subcutaneously. Rats were sacrificed 10 days later to determine the wound breaking strength and reparative collagen deposition. Blood lymphocytes were analyzed by FACS. Immunohistochemistry was performed on wound sections.Results. Irradiation significantly reduced wound collagen deposition and wound breaking strength (p <0.05), leading to a 78% reduction in collagen deposition and 47% reduction in breaking strength in 24 Gy animals. Blood lymphocytes were not affected by electron-irradiation, suggesting that the wound was not affected by radiation-induced systemic effects. Impaired healing was reflected, however, in increased expression of wound CD8 cells and decreased expression of CD25 (IL-2 receptor) (p <0.01). No effect was seen on wound CD4 cells. In addition, the ratio of CD4/CD8 was significantly decreased (p <0.05).Conclusions. Radiation-impaired healing is reflected in impaired expression of wound lymphocyte subtypes. Altered lymphocyte subtypes may affect the outcome of healing in irradiated wounds.

8

Does regular physical exercises during radiotherapy influence on fatigue, and physical endurance in high-risk prostate cancer patients?

86%

Hojan K., Milecki P.

Medical Rehabilitation

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2019

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vol. 23(4)

21-27

PL

Wstęp: Podczas radioterapii (RT) pacjenci z rakiem prostaty (PCa) bardzo często zgłaszają uczucie zmęczenia, które upośledza sprawność funkcjonalną, stan psychiczny i jakość życia (QoL). Powszechnie wiadomo, że ćwiczenia fizyczne odgrywają ważną rolę u zdrowych osób ale mają też pozytywny wpływ na wiele aspektów immunologicznych zdrowia i poprawiają QoL u pacjentów z nowotworami. Wcześniejsze badania wykazały, że ćwiczenia fizyczne u pacjentów z chorobą nowotworową poddawanych RT poprawiają wydolność serca i QoL. Nadal jednak nie jest dobrze znane, jak ćwiczenia fizyczne wpływają na sprawność fizyczną czy uczucie zmęczenia u pacjentów z PCa w czasie RT. Dlatego celem tego badania było zbadanie wpływu nad zorowanego treningu fizycznego na wytrzymałość fizyczną oraz uczucie zmęczenia u pacjentów z PCa o wysokim ryzyku progresji, poddanych RT. Materiały i metody: Było to prospektywne, dwuramienne, randomizowane i kontrolowane badanie kliniczne. Przeprowadzono je u pacjentów leczonych ambulatoryjnie w Wielkopolskim Centrum Onkologii. Przed podjęciem RT, siedemdziesięcioro dwóch mężczyzn z PCa o wysokim ryzyku progresji, zostało losowo przydzielonych do dwóch grup. Trzydziestu sześciu pacjentów wykonywało regularne, nadzorowane ćwiczenia fizyczne o umiarkowanej intensywności (grupa ćwiczeń, ang.exercise group, EG), a pozostałe 36 osób utworzyło grupę kontrolną, która wykonywała normalną codzienną aktywność fizyczną (zwykła grupa; ang. usual group, UG). Zarówno przed jak i po RT oceniano następujące parametry: ogólną wytrzymałość fizyczną, zmęczenie. Wyniki: Nie stwierdzono istotnych różnic pomiędzy grupami w badaniu przed RT. Natomiast po RT nastąpiła znacząca poprawa wytrzymałości fizycznej (p <0,05) i mniejsze objawy zmęczenia w EG. Wniosek: Regularne, umiarkowanie intensywne ćwiczenia fizyczne poprawiają wytrzymałość fizyczną i mają pozytywny wpływ na zmniejszenie objawów zmęczenia podczas RT u pacjentów z PCa o wysokim ryzyku progresji choroby. Dlatego aby zmniejszyć skutki uboczne leczenia w czasie RT, ta grupa pacjentów powinna przeprowadzać regularny trening fizyczny.

EN

Background: During radiotherapy (RT) prostate cancer (PCa) patients very often report fatigue, which impairs functional capacity, psychological status, and quality of life (QoL). It is well known that physical exercise plays an important role in healthy adults, has a positive role in immunological aspects of health and improves QoL in cancer patients. Previous studies have shown that physical exercise in cancer patients undergoing RT improves cardiac fitness and QoL. However, it is still not well understood how physical exercise affects physical fitness or fatigue in PCa patients during RT. Therefore, the purpose of this study was to examine the effect of supervised physical exercise on physical endurance and fatigue in high-risk PCa patients undergoing RT. Material and Methods: This was a prospective, two-arm randomized controlled clinical trial. The study was performed with outpatients of the Greater Poland Cancer Center. Seventy-two high-risk PCa men were randomly allocated to two groups prior to undergoing RT. Thirty-six patients performed supervised moderately intense physical exercise (exercise group; EG) and the other 36 formed a control group that carried out normal daily physical activity (usual group; UG). The following parameters were assessed before and after RT: physical endurance, fatigue scores. Results. No significant differences existed between the study groups at pre-RT assessment. After RT, there was a significant improvement in physical endurance (p<0.05) and important smaller fatigue scores in EG. Conclusion. Regular, moderately intense physical exercise improves physical endurance and has a positive influence on symptoms of fatigue during RT in high-risk PCa patients. Therefore, this patient group should conduct regular physical training during RT to decrease the side effects of treatment.

9

Radiation conditions in the Hornsund area (Spitsbergen)

86%

Głowicki B., Głowicki B.

Polish Polar Research

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1985

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vol. 6

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issue 3

Refine search results

Cardiac endothelial cells isolated from mouse heart - a novel model for radiobiology

Radiative spectra of thermal electromagnetic noise induced by planar realistic dielectrics

Radon Measurements in Groundwater Mines in La Palma and El Hierro, Canary Islands (Spain)

Radiation of Sound Waves by a Semi-Infinite Duct with Outer Lining and Perforated End

Radiation Degradation of Bipolar Transistor Current Gain

The prognostic significance of histology and treatment modality in stage IB1 squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the uterine cervix: SEER study 2004–2008

Role of T-lymphocytes in Radiation-Impaired Wound Healing

Does regular physical exercises during radiotherapy influence on fatigue, and physical endurance in high-risk prostate cancer patients?

Radiation conditions in the Hornsund area (Spitsbergen)