Results found: 3

Number of results on page

Search results

Search:
in the keywords: prostaglandins

Sort By:

Limit search:

Constriction of Fetal Ductus Arteriosus and Maternal Intake of Polyphenol-Rich Foods

100%

Zielinsky P.

2014

vol. 4

issue 4

6-18

Fetal ductal constriction is a potentially severe functional alteration, often causing right ventricular overload and insufficiency, tricuspid regurgitation and neonatal pulmonary hypertension. Classically, maternal administration of indomethacin and/or other nonsteroidal antiinflammatory drugs interfere in prostaglandin metabolism, leading to ductal constriction. However, many cases of fetal ductal constriction, as well as of persistent neonatal pulmonary artery hypertension, remain without an established etiology, being referred as “idiopathic”. In recent years, a growing body of evidences has shown that herbs, fruits, nuts, and a wide diversity of substances commonly used in daily diet, because of their high content of polyphenols, have definitive effects upon the metabolic pathway of inflammation, with consequent inhibition of prostaglandins synthesis. This anti-inflammatory action of polyphenols, when ingested during the third trimester of pregnancy, may interfere with the dynamics of fetal ductus arteriosus flow and cause ductal constriction. This review has the purpose to approach these new evidences, which may influence dietary orientation during pregnancy.

Identification of lipid derivatives in Hep G2 cells

86%

Gdula-Argasińska J., Garbacik A., Tyszka-Czochara M., Woźniakiewicz M., Paśko P., Czepiel J.

Acta Biochimica Polonica

2013

vol. 60

issue 4

811-815

Metabolism of polyunsaturated fatty acids results in biosynthesis of mediators with different physiological effects. These metabolites include prostaglandins, prostacyclins, isoprostanes and others that are important signalling molecules and regulate a variety of physiological and pathophysiological processes including inflammation. Prostaglandins and isoprostanes are produced by either non-enzymatic lipid peroxidation or by enzyme-induced peroxidation (cyclooxygenases and lipoxygenases). They are used as biomarkers of oxidative stress. The aim of our study was to assess the effect of eicosapentaenoic acid (EPA) supplementation with added benzo(a)pyrene (BaP) on HepG2 cells by using a UHPLC/MS-TOF method. This rapid and simple method was developed for the identification, separation and quantification of 8-iPGF3α, PGF3α, 8-isoPGF2α and 5-iPF2α in cultured cells. The UHPLC/MS-TOF method was validated. The calculated limit of detection was in the range of 0.16-0.50 ng/mL, precision (% RSD): 1.2-2.1% and recoveries better than 88%. This method empowered qualitative and quantitative analysis of the selected individual prostaglandins derived from arachidonic acid and eicosapentaenoic acid from cell extracts.

Labor induction at full-term and post-term pregnancies

86%

Modrzyńska A., Radoń-Pokracka M., Płonka M., Adrianowicz B., Wilczyńska G., Nowak M., Huras H., Modrzyńska A., Radoń-Pokracka M., Płonka M., Adrianowicz B., Wilczyńska G., Nowak M., Huras H.

Folia Medica Cracoviensia

2019

vol. 59

issue 4

Refine search results

1 Acta Biochimica Polonica

1 Folia Medica Cracoviensia

1 Prenatal Cardiology

1 2019

1 2014

1 2013

1 Adrianowicz B.

1 Czepiel J.

1 Garbacik A.

1 Gdula-Argasińska J.

1 Huras H.

1 Modrzyńska A.

1 Nowak M.

1 Paśko P.

1 Płonka M.

1 Radoń-Pokracka M.

1 Tyszka-Czochara M.

1 Wilczyńska G.

1 Woźniakiewicz M.

1 Zielinsky P.

Search results

Constriction of Fetal Ductus Arteriosus and Maternal Intake of Polyphenol-Rich Foods

Identification of lipid derivatives in Hep G2 cells

Labor induction at full-term and post-term pregnancies