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  1. 1 Acta Biochimica Polonica

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  1. 1 2013

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  1. 1 Bialik-Wąs K.

  2. 1 Pielichowski K.

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Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation

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Bialik-Wąs K., Pielichowski K.
Acta Biochimica Polonica
|
2013
|
vol. 60
|
issue 4
835-838
EN
We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and 1H NMR, as well as surface morphology assessment by SEM, were performed.
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