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INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2023
|
vol. 28
111-118
EN
The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.
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CHITOSAN GELS TO PREVENT REFLUX DISEASE

100%
Małolepsza-Jarmołowska K.
|
EN
Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.
3
Publication available in full text mode
Content available

INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2023
|
vol. 28
111-118
EN
The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.
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