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PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

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Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2018
|
vol. 23
130 - 139
EN
The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.
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THE EFFECT OF A CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROPERTIES OF HYDROPHILIC POWDERS CONTAINING A LACTIC ACID-CHITOSAN COMPLEX

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2018
|
vol. 23
120 - 129
EN
The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.
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