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Serum Osteocalcin Concentration in Treadmill-Trained Adult Male Wistar Rats

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Nowak A., Pogrzebna M., Celichowski J., Pilaczyńska-Szcześniak Ł.
Journal of Human Kinetics
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2008
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vol. 19
121-130
EN
Mechanical stress is considered to be essential for the regulation of bone mass. The purpose of this study was to determine whether treadmill exercise at moderate intensity induces alterations in blood osteocalcin concentration in rats. Male Wistar rats, aged 5 months, were divided randomly into two groups: trained animals (n = 6) and controls (n = 7). Trained rats were exercised 5 days/week for 4 weeks on a motor-driven treadmill. Each exercise session lasted 60 minutes and the average locomotion speed was 16.2 m/min. After completion of the training period, a blood sample was taken for osteocalcin measurement and the hindlimbs medial gastrocnemius muscles were excised and weighed. Comparative analysis showed significantly lower circulating osteocalcin levels in the exercised rats in comparison to control animals. It is possible that the observed decreased blood osteocalcin concentration is transient in nature. Factors including stress may also influenced the results.Serum osteocalcin concentration in treadmill-trained rats
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Relation of the protein glycation, oxidation and nitration to the osteocalcin level in obese subjects

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Razny U., Goralska J., Zdzienicka A., Fedak D., Masania J., Rabbani N., Thornalley P., Pawlica-Gosiewska D., Gawlik K., Dembinska-Kiec A., Solnica B., Malczewska-Malec M.
Acta Biochimica Polonica
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2017
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vol. 64
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issue 3
415-422
EN
Carboxylated osteocalcin (Gla-OC) contributes to the bone formation, whereas its undercarboxylated form (Glu-OC) takes part in the energy metabolism. In vitro studies had shown that treatment of osteoblast-like cells with advanced glycation end product-modified bovine serum resulted in reduced synthesis of collagen 1 and osteocalcin. The aim of this study was to find association between Gla-OC and markers of protein glycation, oxidation and nitration, as well as pro-inflammatory and antioxidant defense markers in obese subjects. Non-obese [(body mass index (BMI)<30 kg/m; n=34)] and obese subjects (30
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Molecular cloning, recombinant expression, and purification of osteocalcin in sika deer (Cervus nippon) antler

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Li X., Liu M., Bai X., Li Y., Zhao Y., Wang S., Wang J., Li X., Liu M., Bai X., Li Y., Zhao Y., Wang S., Wang J.
Polish Journal of Veterinary Sciences
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2019
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issue 1
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