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EN
The aim of this work was to create a numerical model of scintillation detector and to check whether such detector can be used for the measurements of internal contamination in emergency conditions. The purpose of the measurements would be only detection of possible contamination, without identification of radioactive isotopes, and hence without estimation of effective dose. However, in emergency conditions, it is sufficient for the rapid selection of a group of contaminated persons, who should be subjected to careful inspection in the laboratory conditions. The calculations were performed for three detector positions relatively to the phantom. The distribution of dose rate was also calculated, in order to find the best geometry for dose rate measurements around human body. Another problem under consideration was the possible influence of radioactive contamination in the environment on the registration of the gamma spectrum emitted from the whole body phantom. Performed calculations showed that there is a possibility to measure internal contamination outside laboratory, even in contaminated area.
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vol. 9
17-29
EN
The Morasko strewn field located near Poznań, in Poland is an excellent example of well preserved strewn ellipse with several small hypervelocity impact craters. Although many studies on this crater field has been conducted since the first meteorite finding in 1914, the discussion of the strewn ellipse, its shape, size and direction is still ongoing. The proper answers on many questions concerning the Morasko impact can be given by numerical modeling. In this paper the implications of the Morasko meteoroid entry parameters on the observed strewn ellipse are presented. It is shown by numerical modeling, that the Morasko impact occurred from the NE direction, with the shallow horizontal angle. The strewn ellipse size is modeled together with the number of big meteorites which probably remain in the Morasko reserved area deep in the ground. The results described in this paper clearly indicate that the strewn ellipse related to the Morasko fall is elongated no more than several kilometers and contain over a dozen meteorites weighting more than 100 kilograms.
8
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A model of axonal transport drug delivery

88%
Open Physics
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2012
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vol. 10
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issue 2
320-328
EN
In this paper a model of targeted drug delivery by means of active (motor-driven) axonal transport is developed. The model is motivated by recent experimental research by Filler et al. (A.G. Filler, G.T. Whiteside, M. Bacon, M. Frederickson, F.A. Howe, M.D. Rabinowitz, A.J. Sokoloff, T.W. Deacon, C. Abell, R. Munglani, J.R. Griffiths, B.A. Bell, A.M.L. Lever, Tri-partite complex for axonal transport drug delivery achieves pharmacological effect, Bmc Neuroscience 11 (2010) 8) that reported synthesis and pharmacological efficiency tests of a tri-partite complex designed for axonal transport drug delivery. The developed model accounts for two populations of pharmaceutical agent complexes (PACs): PACs that are transported retrogradely by dynein motors and PACs that are accumulated in the axon at the Nodes of Ranvier. The transitions between these two populations of PACs are described by first-order reactions. An analytical solution of the coupled system of transient equations describing conservations of these two populations of PACs is obtained by using Laplace transform. Numerical results for various combinations of parameter values are presented and their physical significance is discussed.
EN
The aim of this paper is to investigate, by means of a numerical simulation, the effect of the half-life of cytoskeletal elements (CEs) on superposition of several waves representing concentrations of running, pausing, and off-track anterograde and retrograde CE populations. The waves can be induced by simultaneous microinjections of radiolabeled CEs in different locations in the vicinity of a neuron body; alternatively, the waves can be induced by microinjecting CEs at the same location several times, with a time interval between the injections. Since the waves spread out as they propagate downstream, unless their amplitude decreases too fast, they eventually superimpose. As a result of superposition and merging of several waves, for the case with a large half-life of CEs, a single wave is formed. For the case with a small half-life the waves vanish before they have enough time to merge.
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