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Neuroendocrine Carcinoma of the Head and Neck – review of literature

100%
Berger G., Dawidziuk T., Chyczewski L.
Polski Przegląd Otorynolaryngologiczny
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2016
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vol. 5(4)
16-21
EN
Neuroendocrine carcinoma is a rare neoplasm, and its most common location in the head and neck area is the larynx, especially the epiglottis and the supraglottic region. The first case of neuroendocrine carcinoma of the larynx was reported in 1969 by Goldman et al. Expression of the two crucial markers, synaptophysin and chromogranin, along with neural cell adhesion molecule (CD56) should be mentioned among the neuroendocrine features detected on immunohistochemistry. Human papilloma virus (HPV16/18) infection in the laryngeal neuroendocrine carcinoma can be one of the causal factors, and the detection of HPV should be considered as a standard procedure for the diagnosis and treatment.
2
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Neuroendocrine Carcinoma Responsible For Gastrointestinal Tract Perforation

80%
Domurat M., Juchimiuk M., Kędra B.
Polish Journal of Surgery
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2010
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vol. 82
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issue 10
577-580
EN
In terms of their clinical and histopathologic presentation, neuroendocrine gastrointestinal tumours constitute an extremely diversifed group of malignancies and thus are difficult to diagnose. Late and often accidental diagnosis means a multistage therapeutic process. The authors present the case of a 78-year-old female patient with clinical symptoms of visceral perforation followed by diffuse peritonitis. The patient was immediately operated. Intraoperative presentation revealed annular narrowing of the intestinal lumen by a tumour located in the cecum just above Bauhin's valve. The free tenia was microperforated in the described lesion area and had been the primary cause of diffuse fibrinous and pyogenic peritonitis. In addition, choleliths were found in the gallbladder. Right hemicolectomy with regional lymphadenectomy and cholecystectomy were performed. No postoperative complications. Histopathologic examination of resected specimen returned carcinoma neuroendocrinale. The authors argue, that the uncommon clinical course and circular, closing growth of the small cecum-located tumour with coincident perforation may originally suggest non-epithelial disease background.
3
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Changes in the pathomorphological diagnosis of gastrointestinal neuroendocrine neoplasms in 2017

70%
Nasierowska-Guttmejer A.
OncoReview
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2017
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vol. 7
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issue 3
109-115
EN
The following changes were introduced in 2017 WHO and TnM classifications: 1. a new group of well-differentiated neuroendocrine tumors with the proliferation index of more than 20% and mitotic count of 20 per 10 hpf (NET G3), formerly classified under neuroendocrine carcinomas (NEC G3) 2. the division of poorly differentiated neuroendocrine tumors (PD NET) with the Ki-67 index of more than 20% into two groups in terms of the degree of differentiation and prognosis: NET G3 and NEC. 3. the replacement of MANEC with MINEN within the mixed group 4. the verification of histological grading (G) criteria 5. new TNM staging criteria, based on ENETS guidelines.
4
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Neuroendocrine carcinoma of the mammary gland. A case report of synchronous occurrence of two different carcinomas in one breast

61%
Lorek A. J., Boratyn-Nowicka A.
Annales Academiae Medicae Silesiensis
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2018
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issue 72
252-256
EN
The paper presents a case of primary neuroendocrine breast carcinoma that coexisted with a typical infiltrating carcinoma (BC) within the same mammary gland. It was diagnosed post-operatively on histopathological examination and confirmed by immunohistochemical analysis.
PL
W pracy przedstawiono przypadek pierwotnego neuroendokrynnego raka piersi, który współwystępował z typowym rakiem naciekającym (BC) w tym samym gruczole piersiowym. Został zdiagnozowany pooperacyjnie w badaniu histopatologicznym i potwierdzony w badaniach immunohistochemicznych.
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