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Retinopathy severity correlates with RANTES concentrations and CCR5-positive microvesicles in diabetes

100%
Tokarz A., Konkolewska M., Kuśnierz-Cabala B., Maziarz B., Hanarz P., Żurakowski A., Szuścik I., Stępień E. Ł., Tokarz A., Konkolewska M., Kuśnierz-Cabala B., Maziarz B., Hanarz P., Żurakowski A., Szuścik I., Stępień E. Ł.
Folia Medica Cracoviensia
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2019
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vol. 59
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issue 3
2
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Air-conducted cervical and ocular vestibular evoked miogenic potentials in patients with Susac’s syndrome

86%
Lachowska M., Zakrzewska-Pniewska B., Nojszewska M., Niemczyk K.
Polski Przegląd Otorynolaryngologiczny
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2018
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vol. 7(2)
8-15
EN
Aim: To evaluate acoustically evoked cervical and ocular vestibular miogenic potentials (AC cVEMP and oVEMP) in patients with Susac’s syndrome. We did not seek for a diagnostic replacement test in those patients, but we investigated if the combined application of AC cVEMP and oVEMPs might be helpful as an additional source of information about the disease. Material and methods: To record VEMPs, the EMG standardization method was used to continuously monitor and minimize the variability of the recordings. The stimuli were presented unilaterally one ear at a time. The waveforms were analyzed for the response, latency and amplitude. Susac’s syndrome is a rare disease and two patients were analyzed in this study. Results: In patient #1 stimulation resulted in responses on both sides with latencies within normal and symmetry limits for both c- and oVEMPs; however, the responses presented small amplitudes for cVEMPs. In patient #2, only cVEMPs were present. The P1 latencies were within normal values but amplitudes were low, in addition showing asymmetry between sides, with right side amplitude being smaller. Conclusion: The information provided by the combined application of AC cVEMP and oVEMP might be useful in the diagnostics of Susac’s syndrome revealing additional information about the affected vestibular system and be of help in the treatment and rehabilitation planning.
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The way it was and the way it should be - the new approach to the treatment of nonproliferative diabetic retinopathy

72%
Misiuk-Hojło M., Kręcicka J.
OphthaTherapy
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2021
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vol. 8
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issue 4
233-237
PL
Cukrzyca została uznana przez Światową Organizację Zdrowia za epidemię XXI w. Retinopatia cukrzycowa należy do głównych komplikacji cukrzycy i wiodących przyczyn utraty wzroku wśród aktywnych zawodowo dorosłych. Jest to mikroangiopatia, w której dochodzi do uszkodzenia głównie drobnych naczyń, ponieważ są one najbardziej wrażliwe na hiperglikemię. W ramach działań prewencyjnych kluczowe są adekwatne monitorowanie metaboliczne cukrzycy, w tym wyrównane wartości hemoglobiny glikowanej, ciśnienia tętniczego oraz lipidogramu. Niezwykle ważne są również regularne kontrole okulistyczne i okresowe badania obrazowe siatkówki. Od lat naukowcy poszukują terapii umożliwiającej zahamowanie zmian naczyniowych w cukrzycy. W maju 2021 r. Polskie Towarzystwo Okulistyczne opublikowało stanowisko grupy eksperckiej w zakresie stosowania sulodeksydu jako leczenia wspomagającego w łagodnej oraz średnio zaawansowanej retinopatii cukrzycowej. Sulodeksyd chroni śródbłonek naczyń, wpływa na czynność jego komórek, ma właściwości profibrynolityczne, przeciwzapalne i wazoregulujące. Cechy te czynią go obiecującym czynnikiem protekcyjnym w pierwszych fazach retinopatii cukrzycowej.
EN
Diabetes has been declared an epidemic of the XXIst century by the World Health Organisation. Diabetic retinopathy, one of its main complications, is a leading cause of vision impairment among professionally active adults. Diabetic retinopathy is a microangiopathy that affects mainly small vessels, due to their highest vulnerability to hyperglycemia. Preventive measures involve mainly strict diabetic follow-ups, balanced level of glycated hemoglobin, blood pressure values and analysis of lipids. Regular ophthalmological check-ups and imaging tests of the retina are also extremely significant. For many years scientists have searched for a therapy to suppress vascular changes in diabetes. In May 2021 a stance on sulodexide use as a supporting treatment in mild and intermediate diabetic retinopathy was published by the Polish Society of Ophthalmology. Sulodexide protects vascular endothelium, contributes to endothelial cells’ function and has profibrinolytic, anti-inflammatory and vasoregulatory properties. These features make it a promising protective agent in the early stages of diabetic retinopathy.
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