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1

The effect of short-term lithium treatment on head twitches induced by 5-hydroxytryptophan in mice

100%

Szymczyk H., Danilczuk Z., Wielosz M.

Current Issues in Pharmacy and Medical Sciences

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2015

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vol. 28

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issue 4

264-268

EN

The effectiveness of lithium in the treatment of affective disorders is well documented. However, the mechanism of this effect is still unknown. The purpose of this study was to investigate the effect of lithium on serotonergic neurons. The evaluation of the serotoninergic system activity was performed on the basis of an experimental model of head twitch response triggered by direct or indirect stimulation of serotonin 5-HT2 receptors in the brain. The obtained results indicated that the lithium chloride co-applied with a direct precursor of serotonin - 5-hydroxytryptophan used in a threshold dose and with carbidopa, generated head twitch response in mice. What is more, an enhancement of head twitch response in mice was observed after repeated 5-hydroxytryptophan application in head twitch-evoking doses. Moreover, inhibition of the serotonine storage in nerve endings in mice was evoked by reserpine administration. Furthermore, lithium increased the effect of 5-hydroxytryptophan given in a threshold dose and a head twitchevoking dose, respectively. In addition, when P-chlorphenylalanine (pCPA), an inhibitor of the serotonin synthesis within the serotonergic neurons, was given simultaneously with the lithium chloride, carbidopa and 5-hydroxytryptophan in the threshold dose, as well as with the lithium chloride and 5-hydroxytryptophan given at head twitchevoking dosage, pCPA administration decreased the number of head twitches responses in both experimental models, as well as in the reserpinized mice subjected to the lithium chloride and 5-hydroxytryptophan application. Finally, 5,7-dihydroxytryptamineevoked serotoninergic nerve endings destruction led to absolute inhibition of headtwitch response when observed after the lithium and 5-hydroxytryptophan application. Moreover, the increase by lithium 5-hydroxytryptophan-evoke head twitch response was inhibited by administration of the ritanserine - a 5-HT2 serotonin receptor blocking agent. In summary, our data show that lithium induced an enhancement of serotonergic neurotransmission due to its action on presynaptic serotonergic terminals.

2

Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae

88%

Zhang Y., Yang T., Huang F., Zhang Y., Yang T., Huang F.

Polish Journal of Veterinary Sciences

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2020

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vol. 23

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issue 4

3

ANXIOLYTIC-LIKE ACTIVITY OF PZ-1433, A NOVEL ARYLSULFONAMIDE DERIVATIVE OF ARYLOXY(PROPYL)PIPERIDINE, IN RODENTS

88%

PARTYKA A.

Medicina Internacia Revuo

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2018

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vol. 28

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issue 110

35-46

EN

A novel arylsulfonamide derivative of aryloxy(propyl)piperidine PZ-1433, has been proved to possess a preclinical activity profile appropriate for the treatment of depression and memory impairments. In the present study its pharmacological activity toward anxiety symptoms as well as its anxiolytic properties have been examined in mouse and rat models. PZ-1433 significantly increased the number of punished crossings and decreased the number of buried marbles in two tests conducted in mice. Moreover, PZ-1433 evoked anxiolytic-like activity in “conditional” anxiety paradigm in rats, meaningly increasing the number of accepted shocks in the Vogel conflict drinking test. However, it did not produce a significant anxiolytic-like effect in “unconditional” anxiety model, i.e. the elevated plus-maze test. From these results, it is likely that direct antagonism toward serotonin 5-HT7 receptors may be involved in the anxiolytic action of PZ-1433. However, in vitro detected inhibition of serotonin transporter evoked by PZ-1433, might also contribute to this effect.

4

THE EFFECT OF A SINGLE OR MULTIPLE DOSES OF GRAPEFRUIT JUICE ON SOME PHARMACOKINETIC AND PHARMACODYNAMIC EFFECTS OF PARACETAMOL IN MICE

88%

AL ZA'ABI M., ALI B. H., AL-HDHRAMI A.

Acta Poloniae Pharmaceutica - Drug Research

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2019

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vol. 76

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issue 4

753-759

EN

Grapefruit juice (GFJ), a commonly consumed dietary substance, has been shown to alter the disposition of several commonly used drugs. The available data on the effects of GFJ on the paracetamol pharmacokinetics and pharmacodynamics are at variance. The aim of this study was to evaluate the effect of a single or multiple dose of GFJ on some pharmacokinetics and pharmacodynamics aspects of orally given paracetamol (400 mg/Kg). Male mice were randomly divided into three equal groups: mice in the first group were given paracetamol; the second group was given a single oral dose (10 mL/Kg) of GFJ one hour prior to paracetamol administration; the third group was administered multiple oral doses of GFJ (10 mL/Kg) for five consecutive days, and on the last day it was treated with paracetamol. Blood samples were collected 10, 20, 30, and 40 min, and 1, 2, 4, 6 and 8 h after paracetamol administration for subsequent pharmacokinetic analysis. Some mice in the same three groups were also tested for their reactions to thermal (hotplate) and chemical (acetic acid induced – abdominal constriction) nociceptive stimuli. GFJ increased the plasma concentration and area under the plasma concentration curve of paracetamol, to a greater extent after a single dose than multiple doses. It also increased the reaction time in the hotplate test, and reduced abdominal constrictions. GFJ administration increased the plasma concentration and the analgesic effect of paracetamol in mice. The possible implications of these changes in humans and their clinical relevance need to be further investigated.

5

Antidepressant-like and anxiolytic-like activity of a novel indoleamine derivative ADN -2013 in rodents

75%

Wasik A., Partyka A., Jastrzębska-Więsek M., Kołaczkowski M., Wesołowska A.

Medicina Internacia Revuo

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2017

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vol. 28

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issue 108

152-162

EN

A novel indolamine derivative, ADN-2013, has been proved to possess a preclinical activity profile appropriate for the treatment of behavioral and psychological symptoms of dementia. Its antidepressant and anxiolytic properties have been examined in rat and mice models. The receptor mechanisms underlying the antidepressant properties of ADN-2013 have also been elucidated. ADN-2013 significantly shortened the immobility time measured in the forced swim test in mice and rats, producing an effect that was abolished by the dopamine D1-receptor antagonist SCH 23390 in rats. Moreover, ADN-2013 evoked anxiolytic-like activity in both “conditional” and “unconditional” anxiety-like paradigms in mice and rats. From these results, it is likely that direct antagonism toward serotonin 5-HT6 receptors and an indirect effect of dopamine, acting mostly via D1-like receptors, may be involved in the antidepressant action of ADN-2013. However, the partial agonist activity of ADN-2013 toward D2 receptors, observed in in vitro studies, might also contribute to this effect.

6

ANTINOCICEPTIVE AND ANTIANXIETY ACTIVITY OF HYDROETHANOLIC EXTRACTS OF THREE IMPATIENS SPECIES IN MICE

75%

Szewczyk K., Orzelska-Górka J., Polakowska M., Biała G.

Acta Poloniae Pharmaceutica - Drug Research

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2018

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vol. 75

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issue 4

989-1001

EN

The plants of the Impatiens L. (Balsaminaceae) have been used for a long time in folk medicine in different painful conditions, and to treat rheumatism, isthmus and crural aches, fractures, superficial infections, fingernail inflammation. This study was undertaken to determine the pharmacological profile of hydroethanolic extracts from Impatiens glandulifera, I. noli-tangere and I. parviflora. A range of behavioral assessments was applied to evaluate the effects of obtained extracts i.e. measurement of body temperature, tests of locomotor activity and motor coordination, nociceptive reaction and anxiety-like behavior. Hydroethanolic extracts were analyzed for total polyphenol (TPC), flavonoid (TFC), flavones/flavonols (TFFC), and flavonones/dihydroflavonols (TFDC) content. Our results show that the extracts from Impatiens species contain high levels of TPC, TFC, TFFC, and TFDC. Oral (i.e., by gavage) administration of Impatiens L. extracts (except for I. noli-tangere) presented an antinociceptive or/and anti-inflammatory activity in the writhing test. The antinociceptive effect of I. parviflora leaves (100 mg/kg) and I. glandulifera flowers (100 mg/kg) was reversed by naloxone. I. glandulifera flowers and roots extracts (100 mg/kg) increased the reaction time to the thermal stimulus in the hot-plate test. All extracts from I. glandulifera (100 mg/kg) showed antianxiety effect in the elevated plus-maze test. It is worth noting that none of the extracts, at the highest used dose – 0.1 ED50 (200 mg/kg), caused coordination impairments or myorelaxation as measured in the rota-rod and chimney tests. These results seem to suggest that the tested extracts are not neurotoxic.

7

Neurological effects of acute exposure to caffeine and organophosphates in mice

75%

Łukawski K., Raszewski G., Kruszyński K., Czuczwar S. J., Łukawski K., Raszewski G., Kruszyński K., Czuczwar S. J.

Polish Journal of Veterinary Sciences

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2021

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vol. 24

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issue 2

8

Female headstart in resistance to hyperoxia-induced oxidative stress in mice

63%

Šarić A., Sobočanec S., Šafranko Ž., Popović-Hadžija M., Aralica G., Korolija M., Kušić B., Balog T.

Acta Biochimica Polonica

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2014

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vol. 61

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issue 4

801-807

EN

Increased oxygen concentration (hyperoxia) induces oxidative damage of tissues and organs. Oxygen toxicity in hyperoxia is controlled by factors such as sex, age, tissue, strain and hormones. In most species females show lower incidence of some age-related pathologies linked with oxidative stress, which has been attributed to a beneficial effect of ovarian hormones. In this study we found that hyperoxia induced hepatic oxidative damage exclusively in male CBA/H mice, followed by their decreased survival. Histopathological examination revealed that the observed differences in survival were not the consequence of acute lung injury induced by hyperoxia. Next, we observed that an increased Sirt1 protein level in hyperoxia-exposed female CBA/H mice correlated with their lower PPAR-γ and higher eNOS and Sod2 protein levels. In males, higher PPAR-γ and lower Sod2 protein levels were associated with unchanged Sirt1 expression. Although these results are of a correlative nature only, they clearly show that females show better survival, increased resistance to hyperoxia and have generally more efficient defense systems, which suggests that their headstart in resistance to hyperoxia could be a consequence of the beneficial effect of ovarian hormones.

Refine search results

The effect of short-term lithium treatment on head twitches induced by 5-hydroxytryptophan in mice

Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae

ANXIOLYTIC-LIKE ACTIVITY OF PZ-1433, A NOVEL ARYLSULFONAMIDE DERIVATIVE OF ARYLOXY(PROPYL)PIPERIDINE, IN RODENTS

THE EFFECT OF A SINGLE OR MULTIPLE DOSES OF GRAPEFRUIT JUICE ON SOME PHARMACOKINETIC AND PHARMACODYNAMIC EFFECTS OF PARACETAMOL IN MICE

Antidepressant-like and anxiolytic-like activity of a novel indoleamine derivative ADN -2013 in rodents

ANTINOCICEPTIVE AND ANTIANXIETY ACTIVITY OF HYDROETHANOLIC EXTRACTS OF THREE IMPATIENS SPECIES IN MICE

Neurological effects of acute exposure to caffeine and organophosphates in mice

Female headstart in resistance to hyperoxia-induced oxidative stress in mice