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Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations

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Makuszewska M., Litwiniuk-Kosmala M., Bartoszewicz R., Niemczyk K.
Polski Przegląd Otorynolaryngologiczny
|
2020
|
vol. 9
|
issue 3
23-29
EN
Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.
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Publication available in full text mode
Content available

Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations

100%
Makuszewska M., Litwiniuk-Kosmala M., Bartoszewicz R., Niemczyk K.
Polski Przegląd Otorynolaryngologiczny
|
2020
|
vol. 9(3)
23-29
EN
Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.
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