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EN
Introduction. The aim of the study is the evaluation of the usefulness of High-Speed Digital Imaging (HSDI) in the diagnosis of organic dysphonia in a form of oedematous-hypertrophic changes of vocal fold mucosa, morphologically confirmed by Transmission Electron Microscopy (TEM) method in patients working with voice occupationally. Material and methods. The group consisted of 30 patients working with voice occupationally with oedematous-hypertrophic changes of vocal fold mucosa. Parameters of vocal folds vibrations were evaluated using HSDI technique with a digital HS camera, HRES Endocam Richard Wolf GmbH. The image of vocal folds was recorded with a rate of 4000 frames per second. Postoperative material of the larynx was prepared in a routine way and observed in transmission electron microscope OPTON 900–PC. Results. HSDI technique allows to assess the real vibrations of vocal folds and determine many parameters. The results of TEM in the postoperative material showed destruction of epithelial cells with severe vacuolar degeneration, the enlargement of intercellular spaces and a large number of blood vessels in the stroma, which indicates the presence of oedematous-hypertrophic changes of the larynx. Discussion. The ultrastructural assessment confirm the particular usefulness of HSDI method in the diagnosis of organic dysphonia in a form of oedematous-hypertrophic changes. Key words: High-Speed Digital Imaging, oedematous-hypertrophic changes, vocal fold mucosa, larynx
EN
Computational Fluid Dynamics (CFD) is a fluid mechanics department that uses numerical methods to solve fluid flow issues. A review of the literature was done as well to summarize the usage of the CFD method in the assessment of airflow through the upper respiratory tract (GDO), especially in the larynx. CFD is now becoming a very useful tool not only for analyzing airflow patterns and mechanism of particle deposition in the larynx, but also for obtaining information on temperature, pressure and shear stress changes in GDO. It is a tool with which one can safely plan surgical treatment as well as predict its potential effects.
EN
Introduction. The aim of the study is the evaluation of the usefulness of High-Speed Digital Imaging (HSDI) in the diagnosis of organic dysphonia in a form of oedematous-hypertrophic changes of vocal fold mucosa, morphologically confirmed by Transmission Electron Microscopy (TEM) method in patients working with voice occupationally. Material and methods. The group consisted of 30 patients working with voice occupationally with oedematous-hypertrophic changes of vocal fold mucosa. Parameters of vocal folds vibrations were evaluated using HSDI technique with a digital HS camera, HRES Endocam Richard Wolf GmbH. The image of vocal folds was recorded with a rate of 4000 frames per second. Postoperative material of the larynx was prepared in a routine way and observed in transmission electron microscope OPTON 900–PC. Results. HSDI technique allows to assess the real vibrations of vocal folds and determine many parameters. The results of TEM in the postoperative material showed destruction of epithelial cells with severe vacuolar degeneration, the enlargement of intercellular spaces and a large number of blood vessels in the stroma, which indicates the presence of oedematous-hypertrophic changes of the larynx. Discussion. The ultrastructural assessment confirm the particular usefulness of HSDI method in the diagnosis of organic dysphonia in a form of oedematous-hypertrophic changes. Key words: High-Speed Digital Imaging, oedematous-hypertrophic changes, vocal fold mucosa, larynx
EN
Laryngocele is an air-filled or fluid-filled abnormal dilatation of the laryngeal saccule. The paper presents a case of tracheotomy in acute respiratory disorder due to laryngopyocele in a 76-year old woman. The patient complained of swelling of the neck for 3 days before being admitted to the hospital. The tracheotomy was performed to quickly secure the Airways prior to progression of swelling. Computed tomography examination showed the presence of bilateral mixed-type laryngocele ‒ on the right air-filled and on the left fluid-filled. First, the acute infection was treated with antibiotics which were followed by surgical excision of laryngopyocele via an external approach. Tracheotomy removal was performed a few days after surgery. A review of the literature is also presented.
EN
Schwann cell tumours are a rare group of benign neoplasms that origin form peripheral nerves. 0.1%–1.5% develops in the larynx causing hoarseness, difficulty swallowing and dyspnoea. The treatment of choice is surgical resection of the tumour during open type surgery or endoscopic procedure. The chosen surgical technique depends on tumour location, size observed in clinical examination and imaging. Also, clinical manifestation of the disease is included in the decision-making process.
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Introduction: Sarcoidosis is a multi-organ disease characterized by noncaseating granulomas. The lesions are usually localized within the lungs and hilar lymph nodes. The sarcoidosis of the upper respiratory tract (SURT) rate is estimated at 0.5–6%. The involvement of the larynx is extremely rare – it occurs in 1.2% of cases of SURT. Materials and methods. We present a case of a patient with laryngeal sarcoidosis. Results: A 48-year-old man had had a diagnosed of dysphonia for 5 years. A diagnosis of chronic hypertrophic laryngitis was made. Empirical course of methylprednisolone was attempted with a short-term improvement. Due to coexisting skin lesions, he was diagnosed with allergy. Chest CT showed moderately enlarged mediastinal and hilar lymph nodes as well as bilateral nodules around the hila. The bronchial biopsy showed no granulomas. Samples taken during microlaryngoscopy revealed sarcoid infiltrates. Conclusions and discussion: There is no unambiguous test confirming the diagnosis of sarcoidosis. It is a typical example of a diagnosis by exclusion. Laryngeal involvement is extremely rare and occurs in 1.2% of cases of SURT. The clinical course of the disease is often difficult to predict. In many patients, the lesion may undergo spontaneous regression. In patients poorly responding to steroid therapy or developing side effects, cytotoxic drugs may be considered.
EN
Professor Geza Julius Jako was involved in development of CO2 Laser larynx surgery. In 1972 he was the first one to publish clinical case results of using CO2 laser with patients. For the first time in Poland, CO2 laser was used during larynx surgery as ‘surgery knife’ in Otolaryngology Clinic of Medical Academy in Warsaw (WUM) on 28th of April 1983. CO2 Laser was created in Quantum Electronics Institute of Military Technical Academy by Professor Zbigniew Puzewicz team. The CO2 laser was donated to Clinic for medical and scientific purpose thanks to Professor Grzegorz Janczewski, who was the director of Otolaryngology Clinic. The first surgeons, who introduced laser surgery in Poland were Zbigniew Sonnenberg, Ryszard Połubiński and Jadwiga Osuch.
EN
Computational Fluid Dynamics is a rapidly developing instrument with a number of practical applications. CFD simulations have been used for years in aerodynamics, engineering, hydraulics, meteorology, construction, and many other fields. In medicine it was used primarily in pulmonology and cardiology, the areas in which the dynamic properties of the gas and liquid play an important role in the proper functioning of the body. In laryngology, Computational Fluid Dynamics (CFD) is a useful method, which allows calculation and visualization of the changing parameters of air flow in the upper respiratory tract.
EN
Objective: To assess the sensitivity and specificity of larngovideostroboscopy (LVS) in the diagnosis of precancerous and malignant lesions of the vocal folds. Material and methods: In 175 patients (128 men and 47 women), aged 19-88 years, mean age 61.5, who were admitted to the clinic with diagnosed premalignant conditions of vocal fold mucosa (leukoplakia, chronic hypertrophic inflammatory lesions) and thickening or tumor on the vocal fold, there was performed LVS before the laryngeal microsurgery. The LVS study included: localization of the leasion, movement of the vocal folds, mucosal wave, shape of glottis clousure, amplitude and symmetry of vocal fold vibration. In the evaluation, a point scale was applied for the individual functional parameters. The scale ranged from 0 to 14. Patients with impaired vocal fold motion or absent mucosal wave were positive on LVS for malignant lesions. Those with limitted mucosal wave were positive on LVS for dysplastic lesions. The results were compared with the final histopathological examination and the sensitivity, specificity, accuracy, positive (PPV) and negative (NPV) predictive value were calculated. Results: On the basis of histopathological examination, benign lesions (normal or inflammatory mucosa) accounted for 20% of diagnoses, hypertrophy and parakeratosis for 28%, low and middle grade dysplasia accounted for 10% and malignant lesions (high-grade dysplasia, pre-invasive cancer, Invasive cancer) was diagnosed in 42% of patients. The overall mean score for LVS was 4.5 and 8.0, respectively for benign and malignant lesions. Sensitivity, specificity, accuracy, PPV and NPV of LVS in detecting malignant lesions were respectively - 95.6%, 23.8%, 61.1%, 57.6% and 83.3% and in detecting both premalignant and malignant lesions were respectively – 90.7%, 31.4%, 78.9%, 84.1% and 45.8%. Conclusions: Because of the high sensitivity of LVS in detecting precancerous and malignant lesions, this method is a very good tool for screening of pathology within the larynx.
EN
Chronic irritation of the laryngeal mucosa by external factors can lead to the development of dysphonia: hoarseness, change of the voice tone or weakening of its strength. Patients who additionally report alarming symptoms, such as dyspnea, dysphagia, or odynophagia require urgent diagnosis and treatment. Long-term exposure to irritants may lead to the development of numerous recurrent hypertrophic laryngeal lesions requiring continuous otorhinolaryngological care and multiple surgical procedures, as it was in the presented case.
EN
Introduction: A 66-year-old male complained of throat discomfort and odynophagia. Laryngeal fiber optic examination was normal but narrow band imaging was suspicious. USG-FNAC from a cervical lymph node was positive for malignant metastatic carcinoma cells. CECT revealed obliteration of the left pyriform fossa till the level of cricoid cartilage, abutting the ala of the thyroid cartilage, arytenoid cartilage and prevertebral muscles. UGIE revealed an ulcerated mass lesion in the left pyriform fossa. Histopathological examination revealed stratified non-keratinized squamous epithelial lined tissue with subepithelial stroma showing large round to polygonal tumour cells. The tumour cells were surrounded by a lymphoid stroma. On immunohistochemistry the tumour cells were positive for pancytokeratin and negative for CD45, chromogranin and synaptophysin. Lymphocytes were positive for CD45. The diagnosis of lymphoepithelial carcinoma was established. The tumour was inoperable and was treated by radiotherapy. Conclusions: Lymphoepithelial carcinoma is the primary entity of the nasopharynx but rarely seen at sites like oropharynx, larynx and hypopharynx. Only around 50 non-nasopharyngeal cases have been reported till date out of which only 10–12 were in the hypopharynx. Radiotherapy is the mainstay of treatment whereas surgery can be considered for a local disease.
EN
Introduction: The two major recognized risk factors for laryngeal cancer are tobacco and alcohol consumption. However, according to WHO and IARC, occupational factors are probably underestimated. Confirmed/highly probable occupational carcinogens related to laryngeal cancer include asbestos and strong organic acid mists. Probable carcinogens are cement, polycyclic aromatic hydrocarbons (PAH) and wood dust. Suspected carcinogens are organic solvents, formaldehyde, coal/silica dust, leather dust and cotton dust. An important problem of epidemiological studies appears to be the lack of differentiation between laryngeal and hypopharyngeal (squamous cell) carcinomas. Material and Methods: For the purposes of this study, a database of 164 well-documented cases of laryngeal and hypopharyngeal cancers was created by collecting data from 4 centres in Belgium, Italy and France. In order to identify confirmed, probable and suspected carcinogenic risks, jobs and exposures over the whole career of the patients were exhaustively identified and mapped. Confounding factors were taken in account. Results: In general, occupational exposure to known or suspected carcinogens is significantly higher in laryngeal than in hypopharyngeal carcinomas. As regards the exposed subjects, the global occupational exposure profiles differ significantly (10 categories). Asbestos and acid mist exposures are significantly more important in laryngeal carcinoma. Coal/silica dust exposure is significantly more important in pharyngeal carcinoma..
EN
Objective: To assess the sensitivity and specificity of larngovideostroboscopy (LVS) in the diagnosis of precancerous and malignant lesions of the vocal folds. Material and methods: In 175 patients (128 men and 47 women), aged 19-88 years, mean age 61.5, who were admitted to the clinic with diagnosed premalignant conditions of vocal fold mucosa (leukoplakia, chronic hypertrophic inflammatory lesions) and thickening or tumor on the vocal fold, there was performed LVS before the laryngeal microsurgery. The LVS study included: localization of the leasion, movement of the vocal folds, mucosal wave, shape of glottis clousure, amplitude and symmetry of vocal fold vibration. In the evaluation, a point scale was applied for the individual functional parameters. The scale ranged from 0 to 14. Patients with impaired vocal fold motion or absent mucosal wave were positive on LVS for malignant lesions. Those with limitted mucosal wave were positive on LVS for dysplastic lesions. The results were compared with the final histopathological examination and the sensitivity, specificity, accuracy, positive (PPV) and negative (NPV) predictive value were calculated. Results: On the basis of histopathological examination, benign lesions (normal or inflammatory mucosa) accounted for 20% of diagnoses, hypertrophy and parakeratosis for 28%, low and middle grade dysplasia accounted for 10% and malignant lesions (high-grade dysplasia, pre-invasive cancer, Invasive cancer) was diagnosed in 42% of patients. The overall mean score for LVS was 4.5 and 8.0, respectively for benign and malignant lesions. Sensitivity, specificity, accuracy, PPV and NPV of LVS in detecting malignant lesions were respectively - 95.6%, 23.8%, 61.1%, 57.6% and 83.3% and in detecting both premalignant and malignant lesions were respectively – 90.7%, 31.4%, 78.9%, 84.1% and 45.8%. Conclusions: Because of the high sensitivity of LVS in detecting precancerous and malignant lesions, this method is a very good tool for screening of pathology within the larynx.
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