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EN
Objectives: The aim of the study was the analysis of the epidemiology of laryngeal cancer over 10 years in relation to known risk factors and to assess the current survival rates in this group of patients. Methods: The data were retrospectively collected from patients’ medical records, then entered in the database using dedicated software and a statistical analysis was performed. Results: 512 subjects - 443 men (86.5%) and 69 women (13.5%) were enrolled into the study. The male-to-female ratio was 6.4:1. There were 97.1% smoking women and 98% smoking men, however the history of more than 20 cigarettes per day smoking admitted 81.1 % of women and 94.6% of men. Heavy alcohol consumption was the case in 14 (20.3%) women and in 307 (69.3%) men. For both the size of heavy alcohol consumption and the size of excessive tobacco use, there was found statistically significant difference between women and men with laryngeal cancer (p<0.05). In the majority of male and female subjects, the tumour was located in the supraglottis/glottis area. Apparently this tumour location was much more common among women, accounting for 60.9% of cases , while in men was confirmed in 39.3% of cases. The stages of the laryngeal cancer were similarly of high advancement for both the men and women - stages III and IV were confirmed in 82.6% of women and in 77.6% of men. The over 5-year survival rate was 39.1% among women and 37.2% among men. Conclusions Contradictory to decreased exposure to risk factors and the shorter period for diagnosis, the higher stages of cancer were observed in women. Although in women the advancement was higher and the majority of cases were located in unfavourable supraglottic area, the survival rates were higher. Key words: laryngeal cancer, epidemiology, men and women, risk factors
EN
Introduction: One of the most recent methods used in imaging of the larynx is NBI. NBI allows to detect specific patterns of pathological angiogenesis suggestive of premalignant or neoplastic lesions. Aim: The aim of the study was to compare imaging of laryngeal lesions in WLE and NBI in relation to histopathological examination. Material and methods: 333 patients with laryngeal lesions underwent endoscopic evaluation in WLE and NBI. Sensitivity, specificity, PPV, NPV for both methods were calculated. The diagnostic value for WLE and NBI was evaluated for two assumptions: a positive result indicates (1) severe dysplasia and cancer, or (2) only cancer. Results: Sensitivity, specificity, PPV, NPV for the first assumption were, respectively for white light compared to NBI: 95.4% vs 98.5%; 84.2% vs 98.5%; 79.6% vs 97.7% and 96.6% vs 99.0%. The values for the second assumption were: 97.4% vs 100%; 79.3% vs 93.5%; 72.6% vs 89.4% and 98.2% vs 100.0%. Higher sensitivity was observed for the second assumption, while higher specificity was recorded for the first assumption. Specificity was significantly higher for NBI than for WLE (p < 0.001). Conclusions: NBI allows to detect and differentiate laryngeal lesions, which are invisible in WLE. Endoscopic examination, especially in NBI mode, is non-invasive, repeatable and remains a useful tool in the daily practice and diagnosis of patients with pathological lesions in the larynx.
EN
Objectives: The aim of the study was the analysis of the epidemiology of laryngeal cancer over 10 years in relation to known risk factors and to assess the current survival rates in this group of patients. Methods: The data were retrospectively collected from patients’ medical records, then entered in the database using dedicated software and a statistical analysis was performed. Results: 512 subjects - 443 men (86.5%) and 69 women (13.5%) were enrolled into the study. The male-to-female ratio was 6.4:1. There were 97.1% smoking women and 98% smoking men, however the history of more than 20 cigarettes per day smoking admitted 81.1 % of women and 94.6% of men. Heavy alcohol consumption was the case in 14 (20.3%) women and in 307 (69.3%) men. For both the size of heavy alcohol consumption and the size of excessive tobacco use, there was found statistically significant difference between women and men with laryngeal cancer (p<0.05). In the majority of male and female subjects, the tumour was located in the supraglottis/glottis area. Apparently this tumour location was much more common among women, accounting for 60.9% of cases , while in men was confirmed in 39.3% of cases. The stages of the laryngeal cancer were similarly of high advancement for both the men and women - stages III and IV were confirmed in 82.6% of women and in 77.6% of men. The over 5-year survival rate was 39.1% among women and 37.2% among men. Conclusions Contradictory to decreased exposure to risk factors and the shorter period for diagnosis, the higher stages of cancer were observed in women. Although in women the advancement was higher and the majority of cases were located in unfavourable supraglottic area, the survival rates were higher. Key words: laryngeal cancer, epidemiology, men and women, risk factors
EN
Pedigree and clinical data are still very important diagnostic tool useful in estimation of a high risk of a cancer devel-opment, molecular basis research and also determining optimal screening for a single family. In this study the own experience was presented in identification of the risk of cancer prevalence with different organ location among the first degree relatives of 760 patients with laryngeal cancer.
EN
The diagnosis of cancer and its treatment may have a negative influence on patient functioning and coping strategies in malignant diseases. Evaluation of the sense of meaning in life and strategies of coping with cancer were the objectives of this study. In addition, the study compared patient demand for analgesic drugs during the postoperative period after surgical treatment of laryngeal and pharyngeal cancer between patients who assessed their pain with a pain intensity scale and patients who didn’t undergo this type of pain measurement. The study included 71 patients treated in the Clinic of Otolaryngology. Measurements were taken between 24 and 72 hours after the surgery. The following tools were used: the PIL test, the Mini-Mental Adjustment to Cancer (Mini-MAC) scale, a pain intensity numeric rating scale. Additionally, a retrospective review of medical records was conducted. Pain intensity measurement decreased patient demand for analgesic drugs both opioid, and non-opioid medications. The sense of meaning in life significantly increased levels of constructive coping skills in cancer and decreased levels of destructive coping strategies. Accurate assessment of postoperative pain intensity as well as analgesic efficacy increased the effectiveness of pain management, decreased patient demand for analgesic drugs and improved patient care quality. The sense of meaning in life played an important role in the process of developing coping strategies in cancer.
PL
Zdiagnozowanie choroby nowotworowej i jej leczenie może mieć negatywny wpływ na funkcjonowanie pacjenta oraz jego strategię radzenia sobie z chorobą nowotworową. Celem badania była ocena poczucia sensu życia i strategii radzenia sobie z chorobą oraz porównanie zapotrzebowania na leki przeciwbólowe w okresie pooperacyjnym u pacjentów po zabiegach operacyjnych krtani i gardła dolnego, u których stosowano ocenę natężenia bólu i bez stosowania oceny. Badaniami objęto 71 pacjentów Kliniki Otolaryngologii w okresie pooperacyjnym od doby zabiegu do trzeciej doby po zabiegu. W badaniu wykorzystano test PIL, skalę Mini-MAC, numeryczną skalę oceny natężenia bólu oraz zastosowano retrospektywną analizę dokumentacji medycznej. Ocena natężenia bólu zmniejsza u pacjentów zapotrzebowanie na leki przeciwbólowe nieopioidowe i opioidy. Poczucie sensu życia zwiększa w sposób istotny poziom konstruktywnych strategii radzenia sobie z chorobą, a zmniejsza poziom destruktywnych strategii. Prawidłowe monitorowanie bólu pooperacyjnego oraz stopnia ulgi w bólu podnosi skuteczność leczenia bólu, zmniejsza zapotrzebowanie pacjentów na leki przeciwbólowe i podnosi jakość opieki nad chorym. Poczucie sensu życia odgrywa ważną rolę w przyjmowanych strategiach radzenia sobie z chorobą nowotworową.
EN
A rare case of distant metastasis to spinal column – lumbar vertebra (L5) – from laryngeal cancer was reported. It must be noted that in 10 % of cases metastases to vertebral column are fi rst symptom of a neoplastic disease and sixty-fi ve percent of patients with advanced cancer present bone metastases. Metastatic involvement of the bone is one of the most frequent causes of pain in cancer patients and represents one of the fi rst signs of widespread neoplastic disease. Nevertheless metastases to lumbar vertebral column from laryngeal cancer is very rare. In presented case MRI and CT were performed to confi rm metastasis. Laryngological examination revealed tumor of a right part of larynx – squamous cell carcinoma (G2) in histopathological examination. The patient was qualifi ed to palliative radiotherapy and still is under laryngological observation.
EN
Introduction: One of the most recent methods used in imaging of the larynx is NBI. NBI allows to detect specific patterns of pathological angiogenesis suggestive of premalignant or neoplastic lesions. Aim: The aim of the study was to compare imaging of laryngeal lesions in WLE and NBI in relation to histopathological examination. Material and methods: 333 patients with laryngeal lesions underwent endoscopic evaluation in WLE and NBI. Sensitivity, specificity, PPV, NPV for both methods were calculated. The diagnostic value for WLE and NBI was evaluated for two assumptions: a positive result indicates (1) severe dysplasia and cancer, or (2) only cancer. Results: Sensitivity, specificity, PPV, NPV for the first assumption were, respectively for white light compared to NBI: 95.4% vs 98.5%; 84.2% vs 98.5%; 79.6% vs 97.7% and 96.6% vs 99.0%. The values for the second assumption were: 97.4% vs 100%; 79.3% vs 93.5%; 72.6% vs 89.4% and 98.2% vs 100.0%. Higher sensitivity was observed for the second assumption, while higher specificity was recorded for the first assumption. Specificity was significantly higher for NBI than for WLE (p < 0.001). Conclusions: NBI allows to detect and differentiate laryngeal lesions, which are invisible in WLE. Endoscopic examination, especially in NBI mode, is non-invasive, repeatable and remains a useful tool in the daily practice and diagnosis of patients with pathological lesions in the larynx.
EN
Introduction: Management of advanced laryngeal cancer has shown fluctuating trends during the last few decades. Though many extensive reports are available in the literature regarding survival outcomes for advanced laryngeal cancer, there is a paucity of elaborate systematic reviews giving a complete picture of facts and figures. The present analysis brings to attention the most relevant data in a focused and up to date format, for simpler interpretation of evidence-based inference. Objective: To present the trends in the treatment of T4 laryngeal cancer over the past few decades and analyze survival outcomes for different treatment modalities in the management of T4 laryngeal cancer by way of systematic review. Methods : An electronic search was conducted using the terms “total laryngectomy”, “T4 laryngeal cancer”, “survival outcomes” in combination with the following search strategy : Search block Laryngeal cancer - "Laryngeal Neoplasms"[Mesh] OR ((Laryngeal[tiab] OR larynx[tiab] OR "Larynx"[Mesh]) AND (“Neoplasms”[Mesh] OR neoplasm* [tiab] OR tumor* [tiab] OR tumour* [tiab] OR cancer* [tiab] OR malignancy* [tiab] OR carcinoma* [tiab] OR neoplasm* [tiab] OR oncology* [tiab])); Search block Total laryngectomy - "Laryngectomy"[Mesh] OR total laryngectomy*[tiab] OR total laryngopharyngectomy*[tiab] OR total pharyngolaryngectomy*[tiab]; Search block T4 - t4[tiab]. Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, SCOPUS and Cochrane Library. 304 articles had been published till June 2017, which included prospective studies, randomized controlled trials, retrospective studies, and smaller descriptive studies. References of the selected studies were further searched for relevant articles. Apart from this, a search was conducted on Google Scholar to obtain related articles. Results: Numerous studies, as mentioned in this review, provide authentic evidence in relation to the efficacy and outcome of surgical treatment for T4 laryngeal cancer. To address the problem of heterogeneity with regards to patient selection, numerous reports pertaining to T4 patients exclusively have been included. Conclusion: Total laryngectomy remains the gold standard for management of T4a laryngeal cancer. After the unparalleled oncological outcomes of more than a century, the technique has stood the test of time. An exhaustive review of the literature has been presented, discussing the trends in the treatment of advanced laryngeal cancer across different continents. However, it must be specified that the purpose of the study is not to prove one treatment protocol to be superior to the other but to bring out patterns of adherence to protocols and guidelines as suggested by multidisciplinary consensus reports and the consequent outcomes.
EN
Ill applying with extensive infi ltration of new-growth within of larynx will demand radical therapeutic procedure, which is operation completely removals of organ. Aim of work was estimation of voice and speeches ill with vocal fi stula in comparison with oesophageal voice and speech and with physiological. With research one embraced 81 men in age 42–75 of years. Group I – 32 ill with cancer of larynx, to which executed total laryngectomy and placed the voice prosthesis Provox 2. Group II – 30 ill after operation total removals of larynx, whiches used oesophageal speech. The control group III – 19 persons with physiological voice. Research one began from subjective estimation of replacement voices. Then one executed measurements maximum phonation time of vowel „a”. To objective estimation of voice one used polish programme „IRIS”. One compared: maximum intensities of voices for colloquial speech, F0, Jitter, Shimmer and NHR. In subjective estimation voice of the patients with voice prostheses was greater freedom of production and voice of the patients with voice prostheses appeared to be more loud in relation to oesophageal voice. Greatest statistical essential differences one obtained between maximum phonation times of vowels „a” where clearly is visible, that values obtained for voices of the patients with voice prostheses are to nearer values for physiological voices. Obtained averages values of acoustic analysis: F0, Jitter, Shimmer and NHR did not show statistical of essential differences between voices supplementary, though parameters of voice of the patients with voice prostheses one was to nearer parameters of physiological voice. Characterization perceptive and acoustic speech of the patients with voice prostheses in comparison with oesophageal speech is to nearer characterization of physiological speech. Lack of satisfactory effects of rehabilitation of oesophageal speech, should be effective secondary implantation vocal prosthesis.
EN
ntroduction: Laryngeal cancer and its treatment are associated with both short- and long-term side effects, affecting laryngeal functions and having an impact on the quality of life. Material and methods: Retrospective analysis of the medical records of patients receiving surgical or non-surgical, larynx- -preserving treatment for laryngeal cancer. R esults: After termination of the treatment, the highest proportion of patients with bad voice quality was in the glottic carcinoma group (both in early and late phase), with swallowing dysfunction in the transglottic carcinoma group. Compared to the situation before the treatment, the proportion of patients with impaired voice quality (bad voice quality and loss of voice) initially decreased among all groups (except for supraglottic carcinomas), and during the first post-treatment year either increased or did not change. The proportion of patients with no swallowing dysfunction increased in the supraglottic, subglottic and transglottic carcinoma groups. D iscussion: We consider necessary the implementation of a standard pre- and post-treatment monitoring of the voice and swallowing function in the management of patients with laryngeal cancer.
EN
Introduction: Laryngeal cancer and its treatment are associated with both short- and long-term side effects, affecting laryngeal functions and having an impact on the quality of life. Material and methods: Retrospective analysis of the medical records of patients receiving surgical or non-surgical, larynx- -preserving treatment for laryngeal cancer. Results: After termination of the treatment, the highest proportion of patients with bad voice quality was in the glottic carcinoma group (both in early and late phase), with swallowing dysfunction in the transglottic carcinoma group. Compared to the situation before the treatment, the proportion of patients with impaired voice quality (bad voice quality and loss of voice) initially decreased among all groups (except for supraglottic carcinomas), and during the first post-treatment year either increased or did not change. The proportion of patients with no swallowing dysfunction increased in the supraglottic, subglottic and transglottic carcinoma groups. D iscussion: We consider necessary the implementation of a standard pre- and post-treatment monitoring of the voice and swallowing function in the management of patients with laryngeal cancer.
EN
As many as 70-85% of laryngeal and laryngopharyngeal cancers are diagnosed at a high staging, comprising a great diagnostic and therapeutic challenge with influence on poor treatment results. Patients with advanced lesions, that is, stages III and IV, qualify for primary surgical treatment or chemoradiotherapy, depending on the clinical stage, poor prognostic factors and preferences of the patient. Reliable qualifications standards for treatment that would allow to establish homogenous therapeutic recommendations and improvement of treatment results in the group of patients have not yet been developed.
EN
Introduction. Laryngeal cancers are the most common malignant tumours of the head, neck, as well as the respiratory tract. They are more likely to affect men, less often women. Morbidity increases after the age of 50 and increases with each decade. The most common histopathological variant is squamous cell carcinoma. The aim. The aim of the work is to analyse the tasks of the nurse in the care of a patient with laryngeal cancer, located in the home environment. A patient case presentation. A man of 59 years after surgery for a tracheostomia due to cancer, staying at home, under the care of a primary health care nurse. Discussion. The operation to completely remove the larynx constitutes a deep mutilation, which affects both the change in physiological functions, as well as deprives the patient of the possibility of verbal communication with the environment, which affects the mental and social state of the patient. Conclusions. Primary health care nurses face tasks in the area of information, instrumental and emotional support. The overarching goal of nursing care in the oncological patient's home environment is to mobilize his forces and resources to self-care and self-care in relation to his own person, and to assist at different stages of the course of the disease process.
PL
Wstęp. Nowotwory krtani to najczęstsze guzy złośliwe głowy, szyi, a także dróg oddechowych. Częściej dotyczą mężczyzn, rzadziej kobiet. Zachorowalność wzrasta po 50-tym roku życia i rośnie z każdą dekadą. Najczęstszą odmianą histopatologiczną jest rak płaskonabłonkowy. Cel. Celem pracy jest analiza zadań pielęgniarki w pielęgnacji pacjenta z nowotworem krtani, przebywającego w środowisku domowym. Prezentacja przypadku. Mężczyzna lat 59 po zabiegu tracheostomii z powodu choroby nowotworowej, przebywający w warunkach domowych, będący pod opieką pielęgniarki poz. Dyskusja. Operacja całkowitego usunięcia krtani stanowi głębokie okaleczenie, które pływa zarówno na zmianę funkcji fizjologicznych, jak również pozbawia chorego możliwości werbalnej komunikacji z otoczeniem, co rzutuje na stan psychiczny i socjalny pacjenta. Wnioski. Przed pielęgniarką w ramach podstawowej opieki zdrowotnej stoją zadania z obszaru wsparcia informacyjnego, instrumentalnego, a także emocjonalnego. Celem nadrzędnym opieki pielęgniarskiej w środowisku domowym chorego onkologicznie jest mobilizowanie jego sił i zasobów do sprawowania samoopieki i samopielęgnacji w stosunku do własnej osoby, oraz asystowanie na różnych etapach przebiegu procesu chorobowego. Słowa kluczowe: nowotwór krtani, proces pielęgnowania, samoopieka.
EN
The diagnosis of cancer and its treatment may have a negative influence on patient functioning and coping strategies in malignant diseases. Evaluation of the sense of meaning in life and strategies of coping with cancer were the objectives of this study. In addition, the study compared patient demand for analgesic drugs during the postoperative period after surgical treatment of laryngeal and pharyngeal cancer between patients who assessed their pain with a pain intensity scale and patients who didn’t undergo this type of pain measurement. The study included 71 patients treated in the Clinic of Otolaryngology. Measurements were taken between 24 and 72 hours after the surgery. The following tools were used: the PIL test, the Mini-Mental Adjustment to Cancer (Mini-MAC) scale, a pain intensity numeric rating scale. Additionally, a retrospective review of medical records was conducted. Pain intensity measurement decreased patient demand for analgesic drugs both opioid, and non-opioid medications. The sense of meaning in life significantly increased levels of constructive coping skills in cancer and decreased levels of destructive coping strategies. Accurate assessment of postoperative pain intensity as well as analgesic efficacy increased the effectiveness of pain management, decreased patient demand for analgesic drugs and improved patient care quality. The sense of meaning in life played an important role in the process of developing coping strategies in cancer.
PL
Zdiagnozowanie choroby nowotworowej i jej leczenie może mieć negatywny wpływ na funkcjonowanie pacjenta oraz jego strategię radzenia sobie z chorobą nowotworową. Celem badania była ocena poczucia sensu życia i strategii radzenia sobie z chorobą oraz porównanie zapotrzebowania na leki przeciwbólowe w okresie pooperacyjnym u pacjentów po zabiegach operacyjnych krtani i gardła dolnego, u których stosowano ocenę natężenia bólu i bez stosowania oceny. Badaniami objęto 71 pacjentów Kliniki Otolaryngologii w okresie pooperacyjnym od doby zabiegu do trzeciej doby po zabiegu. W badaniu wykorzystano test PIL, skalę Mini-MAC, numeryczną skalę oceny natężenia bólu oraz zastosowano retrospektywną analizę dokumentacji medycznej. Ocena natężenia bólu zmniejsza u pacjentów zapotrzebowanie na leki przeciwbólowe nieopioidowe i opioidy. Poczucie sensu życia zwiększa w sposób istotny poziom konstruktywnych strategii radzenia sobie z chorobą, a zmniejsza poziom destruktywnych strategii. Prawidłowe monitorowanie bólu pooperacyjnego oraz stopnia ulgi w bólu podnosi skuteczność leczenia bólu, zmniejsza zapotrzebowanie pacjentów na leki przeciwbólowe i podnosi jakość opieki nad chorym. Poczucie sensu życia odgrywa ważną rolę w przyjmowanych strategiach radzenia sobie z chorobą nowotworową.
EN
Dysphagia concerns 10–89% patients after total laryngectomy; to a greater extent it regards patients receiving complementary radiotherapy. The disease mechanism is associated with anatomical changes after surgery (typeof surgery) or complications of adjuvant therapy (xerostomia, neuropathy, swelling of tissue, etc.). The above changes lead to: decreased mobility of the lateral walls of the pharynx and tongue retraction, the occurrence of tounge pumping movements, decreased swallowing reflex, weakening of the upper esophageal sphincter opening, contraction of the cricopharyngeal muscle, tissue fibrosis, formation of pharyngeal pseudodiverticulum, etc. As a result: regurgitation of food through the nose and oral cavity, food sticking in middle and lower pharynx, prolongation of bolus transit time. Upon the formation of tracheoesophageal fistula, there may be aspiration of gastric contents. The above changes considerably reduce patients’ quality of life after surgery. The diagnostic protocol includes: medical interview (questionnaires such as EAT 10, SSQ, MDADI, DHI can be helpful), clinical swallowing assessment and instrumental examinations: primarily videofluoroscopy but also endoscopic evaluation of swallowing. Selected cases also require high frequency manometry. The treatment options include: surgical methods (e.g. balloon dilatation of the upper esophageal sphincter, cricopharyngeal myotomy, pharyngeal plexus neurectomy, removal of the pharyngeal pseudodiverticulum), pharmacological treatment or conservative methods (e.g. botulinum toxin injection of the upper esophageal sphincter, speech therapy, nutritional treatment) and supportive methods such as consultation with a psychologist, physiotherapist, clinical dietitian). The selection of a specific treatment method should be preceded by a diagnostic process in which the mechanism of functional disorders related to voice formation and swallowing will be established.
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