Search results

1

Surgical Procedures Not Connected with Transplantation in Patients After Kidney or Kidney and Pancreas Transplant with Stable Function of Graft

100%

Kałuża B., Ziobrowski I., Durlik M.

Polish Journal of Surgery

|

2012

|

vol. 84

|

issue 4

196-201

EN

The aim of the study was to evaluate complication during and after surgical procedure without connection with transplantation among patients after kidney, kidney and pancreas transplantation with stable function of graft.Material and methods. 54 patients underwent 62 surgical procedures without connection with transplantation procedure. Main characteristic: standard immunosuppressive treatment, main age 51.1±13.95 years, men 77.4%, hospitalization time 5.27±3.31 day, group 1 - 55 procedures among patients after kidney transplantation, group 2 - 7 procedure among patients after kidney and pancreas transplantation.Results. Procedures from general surgery comprised 60% [cholecystectomy 19 (51%), left hemicolectomy 1 (3%), esophagus removal 1 (3%), hernia repair 8 (22%), nefrectomy 3 (8%), pancreas transplantation in patients with functional renal graft 1 (3%), laparotomy 4 (11%), vascular surgery 27% (correction of arteriovenosus fistula 13 (76%), by-pass surgery 1 (6%), embolectomy 1 (6%), implantation of aortal - iliac stentgraft 1 (6%), surgery of iliac artery 1 (6%)]. There has been no difference between parameters measured before and after procedure: creatinine (p=0.93), GFR (p=0.07), urea (p=0.25), glycaemia (p=0.322), glycated hemoglobin (p=0.3), C-peptide (p=0.3). In both groups were no differences in levels of creatinine (p=0.78) and urea (p=0.23), measured in the next years after surgical procedure. Mortality 0%, lost of graft 0%, in - hospital morbidity 10 (16.2%) (hematoma 1.6%, endocavitary electrode 1.6%, wound healing defect 16.2%). Morbidity in group 1 - 12.7%, group 2 - 48.8%, p=0.04.Conclusions. Surgical procedures performed in a specialist center do not impaire prognosis of patients with stable function of graft, after kidney, kidney and pancreas transplantation.

2

Aliskiren reduces albuminuria after kidney transplantation

100%

Tylicki L., Debska-Slizien A., Lizakowski S., Przybylska M., Heleniak Z., Renke M., Chamienia A., Biedunkiewicz B., Rutkowski P., Małgorzewicz S., Rutkowski B.

Acta Biochimica Polonica

|

2017

|

vol. 64

|

issue 2

221-226

EN

Background: The renoprotective effects of the direct renin inhibitor, aliskiren, in renal transplant recipients have been supposed, but not finally proven. We performed an exploratory double-blind, losartan controlled, cross-over study to evaluate the influence of aliskiren, direct renin inhibitor, on albuminuria and other surrogate markers of kidney injury in patients after renal transplantation. The safety of this therapy was also evaluated. Method: 16 of 18 patients (12 M, 4 F), 48.3 ± 9.0 years, 57.7 ± 9.1 months after kidney transplantation, with hypertension and stable serum creatinine 1.4 ± 0.08 mg/dl without proteinuria, completed the protocol. Each patient underwent two 8-week treatment periods (one with 150 mg of aliskiren, and one with 50 mg of losartan) in random order, allowing an 8-week placebo washout between them. Results: There were no differences in albuminuria, transforming growth factor β-1 and 15-F2t-isoprostanes urine excretion between aliskiren and losartan. Creatinine serum level, eGFR, 24 h systolic and 24 h diastolic blood pressure were stable through the study. There were no differences in haemoglobin and potassium serum concentration between studied drugs. Conclusion: Aliskiren decreases albuminuria in renal transplant recipients with clinically minimal side effects. The effect does not differ from that of losartan.

3

Influence of Donor and Recipient Gender as well as Selected Factors on the Five-Year Survival of Kidney Graft

100%

Głyda M., Czapiewski W., Karczewski M., Pięta R., Oko A.

Polish Journal of Surgery

|

2011

|

vol. 83

|

issue 4

188-195

EN

The aim of the study was to determine the impact of the gender of renal allograft donor and recipient on the graft function over a 5-year follow-up period.Material and methods. The 154 kidney grafts from 77 donors transplanted into recipients of both genders. Two study groups were formed: one group consisted of male donors, while the other consisted of female donors. The recipients in each of the groups consisted of a pair, one male and one female.Results. 71% of grafts survived the five-year period in the group of male and female recipients when the donor was male; in case of female donors, the rate was 62.5%. Depending on the gender of the donor and the recipient, the rates of grafts with five-year survival were as follows: 79.2% for male donors and female recipients (MF); 62.5% for male donors and male recipients (MM). The difference between both groups was not statistically significant. In the case of female donors and male recipients (FM), the five-year survival rate was 58.3%, while in female donors and female recipients, the five-year survival rate was 64.1%.Conclusions. Grafts from male donors show a trend towards better five-year survival compared to grafts from female donors. The highest five-year survival rate was observed when the donor was male and the recipient was female; the lowest rate was observed for female donors and male recipients.

4

Renal tubular acidosis - underrated problem?

100%

Golembiewska E., Ciechanowski K.

Acta Biochimica Polonica

|

2012

|

vol. 59

|

issue 2

213-217

EN

Renal tubular acidosis (RTA) is a hyperchloremic metabolic acidosis characterized by a normal anion gap and normal (or near normal) glomerular filtration rate in the absence of diarrhoea. Inherited isolated forms of renal tubular acidosis are not common. However, they can also be a part of a more generalized tubule defect, like in Fanconi syndrome. In recent years more and more gene mutations have been found which are associated with RTA (mutations in the gene SLC4A4, encoding a Na+-HCO3- cotransporter (NBC-1); in the gene SLC4A1, encoding Cl-/HCO3- exchanger (AE1); in the gene ATP6B1, encoding B1 subunit of H+-ATPase; in the gene CA2 encoding carbonic anhydrase II; and others) and allow better understanding of underlying processes of bicarbonate and H+ transport. Isolated renal tubular acidosis can be frequently acquired due to use of certain drug groups, autoimmune disease or kidney transplantation. As the prevalence of acquired forms of RTA is common, new therapeutic options for the currently used supplementation of oral alkali, are awaited.

5

Treatment of Vascular Complications After Kidney Transplantation

100%

Wiśniewska-Goryń J., Gorczyca-Wiśniewska E., Goryń T., Andziak P., Durlik M.

Polish Journal of Surgery

|

2008

|

vol. 80

|

issue 3

132-138

EN

The aim of the study was to determine the frequency of occurrence and treatment methods of early vascular complications after kidney transplantation.Material and methods. A retrospective analysis comprised of 245 patients subjected to kidney transplantation during the period between 1998 and 2006 in our department. Of these, 236 patients received organs from deceased donors, while nine patients received organs from living donors. The occurrence of vascular complications and the diagnostic and treatment methods used were determined for each patient. Patients operated on during the period between 1998 and 2001 were compared to those operated on between 2002 and 2006.Results. Twenty-two patients presented with vascular complications after kidney transplantation. The following were observed: bleeding (6.1%), anastomotic stenosis (1.2%), renal vein thrombosis (0.81%), renal artery thrombosis (0.4%), and false aneurysm of the renal artery (0.4%). Nineteen patients underwent surgery, and two required intravascular procedures while one was subjected to conservative treatment. Good treatment results were obtained in 17 patients, while five patients had the transplanted kidney removed.Seventy-eight transplantations were performed in the first four years (1998-2001). In that period, vascular complications occurred in 13 patients (17%). During the following four years (2002-2006) we transplanted 167 patients, and vascular complications were observed in nine patients (5%). Statistical analysis showed a significant reduction (p=0.004-test chi2) in the number of vascular complications during the latter period.Conclusions. As surgeons gain experience treating transplant recipients, the number of vascular complications decreases. Diagnostics and treatment depends on the early visualization of complications by means of Doppler ultrasound and angio-MRI examinations. The use of intravascular techniques could be an effective and safe therapeutic method in the case of vascular complications.

6

Prophylactic intra-abdominal drainage following kidney transplantation: a systematic review and meta-analysis

88%

Zawistowski M., Nowaczyk J., Domagała P.

Polish Journal of Surgery

|

2021

|

vol. 93

|

issue 4

1-10

EN

Introduction: An ongoing debate concerns the need for routine placement of prophylactic intra-abdominal drains following kidney transplantation. Aim: We conducted a systematic review and meta-analysis to determine whether such an approach brings any advantages in the prevention of perirenal transplant fluid collection, surgical site infection, lymphocele, hematoma, urinoma, wound dehiscence, graft loss, and need for reoperation. Methods: We conducted a random-effects meta-analysis of non-randomized studies of intervention comparing drained and drain-free adult renal graft recipients regarding perirenal transplant fluid collection and other wound complications. ROBINS-I tool and funnel plot asymmetry analysis were used to assess the risk of bias. Results: Five studies at moderate to critical risk of bias were included. A total of 2094 renal graft recipients were evaluated. Our analysis revealed no significant differences between drained and drain-free patients regarding perirenal transplant fluid collection (pooled odds ratio [OR], 0.77; 95% confidence interval [CI], 0.28–2.17; I 2 = 72%), surgical site infection (OR, 1.64; 95% CI, 0.11–24.88; I 2 = 80%), lymphocele (OR, 0.61; 95% CI, 0.02–15.27; I 2 = 0%), hematoma (OR, 0.71; 95% CI, 0.12–3.99; I 2 = 71%), and wound dehiscence (OR, 0.75; 95% CI, 0.21–2.70; I 2 = 0%). There was insufficient data concerning urinoma, graft loss, and need for reoperation. Conclusions: The available evidence is weak. Our findings show that the use of intra-abdominal drains after kidney transplantation seems to have neither beneficial nor harmful effects on perirenal transplant fluid collection and other wound complications. The present study does not support the routine placement of surgical drains after kidney transplantation. In this systematic review and meta-analysis we summarize the most up-to-date evidence for and against the routine use of intra-abdominal drain following renal transplantation.

7

Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review

75%

Zachara B. A., Gromadzińska J., Wąsowicz W., Zbróg Z.

Acta Biochimica Polonica

|

2006

|

vol. 53

|

issue 4

663-677

EN

The metabolism of oxygen in aerobic organisms leads to generation of reactive oxygen species (ROS). These entities are able to oxidize almost all classes of macromolecules, including proteins, lipids and nucleic acids. The physiological level of ROS is usually regulated by antioxidant defense mechanisms. There are at least three groups of antioxidant enzymes: superoxide dismutases, catalases and glutathione peroxidases (GSH-Pxs) which neutralize ROS. The trace elements (copper, zinc and selenium) bound to the active sites of the above listed enzymes play an important role in the antioxidant defense system. In mammals, a major function of selenium (Se) and Se-dependent GSH-Pxs is to protect cells from oxidative stress. Selenium concentrations and GSH-Px activities are altered in blood components of chronic kidney disease (CKD) patients. The Se level is frequently lower than in healthy subjects and the concentration very often decreases gradually with advancing stage of the disease. Studies on red cell GSH-Px activity in CKD patients reported its values significantly lower, significantly higher and lower or higher, but not significantly as compared with healthy subjects. On the other hand, all authors who studied plasma GSH-Px activity have shown significantly lower values than in healthy subjects. The degree of the reduction decreases gradually with the progression of the disease. High inverse correlations were seen between plasma GSH-Px activity and creatinine level. A gradual decrease in plasma GSH-Px activity in CKD patients is due to the fact that this enzyme is synthesized predominantly in the kidney and thus the impairment of this organ is the cause of the enzyme's lower activity. Se supplementation to CKD patients has a slightly positive effect in the incipient stage of the disease, but usually no effect was observed in end-stage CKD. Presently, kidney transplantation is the only treatment that may restore plasma Se level and GSH-Px activity in patients suffering from end-stage CKD. A few studies have shown that in kidney recipients, plasma Se concentration and GSH-Px activity are restored to normal values within a period of 2 weeks to 3 months following surgery and thus it can be acknowledged that Se supplementation to those patients has a positive effect on plasma GSH-Px activity.

8

Jakość życia pacjentów dializowanych i po przeszczepie nerek

63%

Gętek M., Nowakowska-Zajdel E., Czech N., Białek A., Muc-Wierzgoń M., Kokot T.

Annales Academiae Medicae Silesiensis

|

2010

|

vol. 64

|

issue 5-6

23-30

EN

BACKGROUND Chronic kidney disease have a signifi cant impact on patient quality of life. The main aim of renal replacement therapy is not only extend life for patients, but also improve its quality. AIM OF THE STUDY The objectives of this study was evaluation of the quality of life of dialysis patients and after kidney transplantation, identifi cation of factors that aff ect the most essential quality of life scores in both groups and compare the quality of life in groups based on gender, age and education. MATERIAL AND METHODS The study was conducted on the basis of a questionnaire WHOQOL-Bref among 40 renal transplant patients (20 women and 20 men) aged from 22 to 64 years (the average was 46 years ± 13) and 80 patients undergoing hemodialysis (40 women and 40 men) aged from 22 to 76 years (the average was 60 years ± 12). RESULTS AND CONCLUSIONS Patients after kidney transplantation better rated their quality of life than dialysis patients across all surveyed areas. Socio-demographic factor, which is the greatest determined the quality of life scores in both groups was gender. In both groups, women better assess their quality of life. Age infl uence on the assessment of quality of life in patients after kidney transplantation: the younger patients (22–34 years), the higher rated quality of life. In both groups training does not aff ect the assessment of quality of life.

PL

WSTĘP Przewlekła choroba nerek znacząco wpływa na jakość życia chorego. Coraz doskonalsze metody leczenia, głównie substytucyjnego, takie jak dializoterapia i transplantacja, pozwalają obecnie wydłużyć życie pacjentom z niewydolnością nerek. Głównym celem terapii nerkozastępczej jest jednak nie tylko przedłużenie życia pacjentów, ale również poprawa jego jakości. CEL PRACY Celami pracy były ocena jakości życia pacjentów dializowanych i pacjentów będących po przeszczepie nerki, wyznaczenie czynników, które wpływają na ocenę jakości życia w obu badanych grupach oraz porównanie jakości życia w grupach w zależności od płci, wieku i wykształcenia. MATERIAŁ I METODY Badanie zostało przeprowadzone na podstawie kwestionariusza WHOQOL- Bref (WHO Quality of Life – BREF) w grupie 40 pacjentów po przeszczepie nerki (20 kobiet i 20 mężczyzn) w przedziale wiekowym 22–64 lat w średnim wieku 46 lat ± 13 oraz w grupie 80 pacjentów poddawanych hemodializie (40 kobiet i 40 mężczyzn) w przedziale wiekowym od 22 do 76 lat w średnim wieku 60 lat ± 12. WYNIKI I WNIOSKI Pacjenci po przeszczepie nerki lepiej ocenili jakość swojego życia w obrębie wszystkich badanych dziedzin w porównaniu do pacjentów dializowanych. Czynnikiem socjodemografi cznym, który w największym stopniu determinował ocenę jakości życia w obu badanych grupach, była płeć. Kobiety lepiej oceniały jakość swojego życia w porównaniu do badanych mężczyzn. Ocena jakości życia w grupie pacjentów po przeszczepie nerki dobrowykazała, że młodsi pacjenci (22–34 lata) wyżej ocenili jakość swojego życia. W obu badanych grupach wykształcenie nie miało wpływu na ocenę jakości życia.

Refine search results

Surgical Procedures Not Connected with Transplantation in Patients After Kidney or Kidney and Pancreas Transplant with Stable Function of Graft

Aliskiren reduces albuminuria after kidney transplantation

Influence of Donor and Recipient Gender as well as Selected Factors on the Five-Year Survival of Kidney Graft

Renal tubular acidosis - underrated problem?

Treatment of Vascular Complications After Kidney Transplantation

Prophylactic intra-abdominal drainage following kidney transplantation: a systematic review and meta-analysis

Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review

Jakość życia pacjentów dializowanych i po przeszczepie nerek