Search results

Search:
in the keywords: kidney stones

Sort By:

Limit search:

Primary hyperparathyroidism on the example of a 33-year-old female patient with parathyroid adenoma

100%

Łach J., Dyaczyński M., Buczkowski K.

Polish Journal of Surgery

2020

vol. 92(3)

55-61

Parathyroid hyperactivity is the state of over-production and PTH secretion [1]. The most common cause of primary hyperparathyroidism is parathyriod adenoma - about 80% of cases, the remaining are parathyroid hyperplasia around 15%cases [2] [3], and in 1-5% of cases, cancer [2] [3] [4] [5]. The disease is diagnosed inabout 40 people in 100,000 [5] [6] [3] [7]. The most common cause of adenoma is the mutation in gene MEN 1. Less than 5% of cases are chronichyperparathyroidism, which is a component of the MEN 1 MEN 2a endocrine adenocarcinoma syndrome [1]. Excess PTH in the body leads to increased mobilization of calcium from the bones, and henceincreased osteolysis, what also increases the absorption of calcium from thedigestive system, as well as an increased amount of phosphate excretion in the urine. Clinical picture of the disease is multiform and often runs in a latent form. Most often the diseaseoccurs in the form of osteoporosis, chronic recurrent kidney stones, and is also commonpyelonephritis on the basis of urolithiasis. The disease may be accompanied by: dysphagia, abdominal pain, metallic taste in the mouth, persistent constipation. In addition, from the systemnervous: dizziness and headaches, disturbances of consciousness. Arrhythmia the form of additional contractions and paroxysmal tachycardia. Osteolysis, osteoporosis and pathological fractures [1]. The purpose of this article is to bring closer to the reader case of 33 years old woman with primary hyperparathyroidism on the adenoma.

Inhibitors of bacterial and plants urease. A review

88%

Macegoniuk K.

Acta Universitatis Lodziensis. Folia Biologica et Oecologica

2013

vol. 9

9-16

Urease is an important virulence factor for Helicobacter pylori and Proteus mirabilis as well as in environmental transformations of certain nitrogenous compounds. Urea hydrolysis caused by these microorganisms leads to increased pH and ammonia toxicity and enables bacterial colonization of the human gastric mucosa and urinary tract formation of struvite and carbonate-apatite stones. Due to the possibility of medical applications the development of novel, selective and efficient classes of urease inhibitors which satisfy the low toxicity requirement for human health and have low environmental impact is necessary. In this article are described the various urease inhibitors used so far by researchers, especially in the last few years.

Refine search results

1 Acta Universitatis Lodziensis. Folia Biologica et Oecologica

1 Polish Journal of Surgery

1 2019

1 2013

1 Buczkowski K.

1 Dyaczyński M.

1 Macegoniuk K.

1 Łach J.

Search results

Primary hyperparathyroidism on the example of a 33-year-old female patient with parathyroid adenoma

Inhibitors of bacterial and plants urease. A review