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Do haematological parameters such as HALP and Lymphocyte to C-reactive protein ratio predict tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer?

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Yordanagil M., Bakir H., Güler Avci G., Yildirim M., Ozkan N., İsmail O.
Polish Journal of Surgery
|
2022
|
vol. 95
|
issue 3
21-29
EN
Aim: Inflammatory markers are effective in determining the prognosis of malignant diseases. The aim of this study is to investigate the relationship of HALP and LCR with tumor response after neoadjuvant chemoradiotherapy and their effects on prognosis in patients with locally advanced rectal cancer. Methods: Eighty-eight patients who received nCRT with the diagnosis of LARC were included in the study. First, all patients were divided into 2 groups: patients with pathological and clinical complete response (pCR+cCR), group 1, and patients with non-complete response, group 2. The 82 patients who underwent surgery were divided into two groups according to the TRG Dworak: good response and poor response groups. Inflammation markers such as HALP and LCR were obtained using biochemical parameters. Results: HALP and LCR were higher in the complete response group than in the none-complete response group (P<0.05). When TRG 3-4 (good response group) and TRG 0-1-2 (poor response group) were compared, HALP and LCR were higher in the good response group (P<0.05). The cut-off point for the HALP value was 30.17, the sensitivity was 88.2%, and the specificity was 43.7%. The cut-off point for the LCR value was 0.402, the sensitivity was 88.2%, and the specificity was 63.4%. It was found that HALP and LCR calculated prior to neoadjuvant CRT could not predict overall survival. Conclusions: We believe that inflammatory markers such as HALP and LCR can effectively identify rectal cancer patients who respond best to nCRT.
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Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis

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Zuwała-Jagiełło J., Pazgan-Simon M., Simon K., Warwas M.
Acta Biochimica Polonica
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2011
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vol. 58
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issue 1
59-65
EN
Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the Child-Pugh score. Plasma concentrations of AOPPs and inflammatory markers such as C-reactive protein, tumor necrosis factor-α, and interleukin-6 were measured in 41 patients with HCV-related cirrhosis, 43 patients with alcohol-related liver cirrhosis (ALC), and in 30 age and sex matched controls. In comparison with controls, AOPPs were increased in HCV-related compensated (Child-Pugh A) and decompensated (Child-Pugh B-C) cirrhosis and in alcohol-related compensated cirrhosis. AOPPs level positively correlated with Child-Pugh score in alcohol-related cirrhosis but not in HCV-related cirrhosis and the correlation with the indices of chronic inflammation was stronger in ALC. In turn, AOPPs in HCV-related cirrhosis was related to inflammation to a lesser extent, but a significant correlation with antioxidant defense could be noted. In summary, liver cirrhosis was associated with increased formation of AOPPs, which differed between alcohol-related and HCV-related cirrhosis with respect to the relationship between AOPPs and antioxidant defense, stage of liver cirrhosis, and inflammatory response. The significant correlation between AOPPs accumulation and indices of chronic inflammation, more specifically TNF-α, suggests that oxidative stress may be a mediator of chronic inflammatory state in the early stage of alcohol-related cirrhosis.
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