Equimolar mixtures of 3,5-dimethylpyrazole (1) with four NH-imidazoles (2–5) have been studied by13C and 15N CPMAS NMR and by DSC. In three cases, the solid mixture behaves as the sum of the individual components [imidazole (2), 2-methylimidazole (3) and 2,4(5)-dimethylimidazole (5)]. In one case [4,5-dimethylimidazole (4)], the mixture corresponds to a new species in which the dynamic behavior of1 no longer exists.
A total of six of 1,2,4,5-tetrasubstituted imidazoles were prepared by multicomponent cyclo- condensation of benzil, aromatic aldehyde, aminoethylpiperazine and ammonium acetate. The prepared compounds were screened for their antibacterial activity against S. aureus, S. typhi, E.coli and Pseudomonas and antifungal activity against A. niger, C. albicans, Rhizopus sp, and Mucor. They exhibited better activities against all the tested bacterial and fungal strains.
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