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Review on analgesic effect of co-administrated ibuprofen and caffeine

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Polski A., Kasperek R., Sobotka-Polska K., Poleszak E.

Current Issues in Pharmacy and Medical Sciences

2014

vol. 27

issue 1

10-13

Pain is a symptom of many diseases and significantly affects the quality of life, so researchers are constantly seeking new substances to be used as analgesics. Other, easier way is to combine already known drugs which cause synergistic effects greater than additive, so that probability of drug-specific side effects can be reduced. Researchers showed that caffeine can be an effective analgesic adjuvant enhancing antinociceptive effect of ibuprofen in animals and humans. By using modern drug technology methods tablets containing well-soluble ibuprofen salt and caffeine can be easily prepared. Thanks to that combination, the therapeutic dose of ibuprofen can be lowered and the side effects may be reduced.

THE STUDY OF PHYSICOCHEMICAL PROPERTIES OF SOLID DISPERSIONS OF IBUPROFEN IN THE PRESENCE OF CHITOSAN

100%

Grimling B., Meler J., Szcześniak M., Pluta J., Górniak A.

Progress on Chemistry and Application of Chitin and its Derivatives

2015

vol. 20

64-72

The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.

MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE

88%

Mucha M., Michalak I., Draczyński Z.

Progress on Chemistry and Application of Chitin and its Derivatives

2013

vol. 18

issue 18

139-147

In view of ongoing interest in biodegradable polymers, dibutyrylchitin was used as a matrix for controlled release of a model substance. Transdermal systems (films) are presently more commonly used as an alternative to standard forms of drug delivery. The presented results are concerned with the release of ibuprofen from dibutyrylchitin film. The obtained transdermal films were modified by applying a control layer to slow down the release process. The matrices were also modified by adding nanoclay (Nanofil 2). Dibutyrylchitin matrices were tested for swelling and release kinetics using UV-Vis spectrophotometer. The drug kinetics release was studied in phosphorus buffer of pH=5.5 at the temperature of 35˚C. Structural investigations of the obtained matrices were carried out by optical microscopy and FTIR spectrophotometry. An appropriate mathematical model was also fitted to the obtained experimental data

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2 Progress on Chemistry and Application of Chitin and its Derivatives

1 Current Issues in Pharmacy and Medical Sciences

1 2015

1 2014

1 2013

1 Draczyński Z.

1 Grimling B.

1 Górniak A.

1 Kasperek R.

1 Meler J.

1 Michalak I.

1 Mucha M.

1 Pluta J.

1 Poleszak E.

1 Polski A.

1 Sobotka-Polska K.

1 Szcześniak M.

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Review on analgesic effect of co-administrated ibuprofen and caffeine

THE STUDY OF PHYSICOCHEMICAL PROPERTIES OF SOLID DISPERSIONS OF IBUPROFEN IN THE PRESENCE OF CHITOSAN

MODIFIED DIBUTYRYLCHITIN FILMS AS MATRICES FOR CONTROLLED IBUPROFEN RELEASE