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EFFECT OF A HYDROPHILISING SUBSTANCE ON THE VISCOSITY OF GYNAECOLOGICAL GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
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2012
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vol. 17
125 - 132
EN
Thus ensuring a continuous action of a drug also during daily activity time of a patient is a vital question in gynaecological treatment. The main problem in applied therapies is to maintain the continuity of treatment during 24 hours. The addition of 5-25% glycerol or 1,2-propylene glycol decreases the pH of investigated gels with calcium alginate to 4.20 to 4.88 (1:1) and 3.69 to 4.19 (2:1); 4.29 to 4.88 (1:1) and 3.62 to 4.40 (2:1). The addition of 5-25% glycerol or 1,2-propylene glycol increases the dynamic viscosity gels with calcium alginate from 595.14 to 820.25 for 1:1 and 640.15 to 769.12 for 2:1; 585.40 to 815.56 for 1:1 and 648.52 to 780.10 for 2:1 ratios. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 with the addition of calcium alginate and glycerol or 1,2-propylene glycol in comparison to the reference gels.
2
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PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

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Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
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2022
|
vol. 27
175-182
EN
The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.
3
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INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
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2022
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vol. 27
183-193
EN
Gastro-oesophageal reflux disease is a serious social problem that affects every sphere of life. The quality of life of people with this disease is reduced due to the presence of troublesome symptoms, which translates into reduced work efficiency and vitality. The major problem is acidic gastro-oesophageal reflux. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and carboxymethylcellulose sodium salt on the protective properties of prepared gels in the treatment of acid reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. Preparations containing 0.3% carboxymethylcellulose sodium salt showed the highest pH. The texture tests showed the effect of carboxymethylcellulose sodium salt concentration on the adhesion work of the tested gels. These gels could be used in the treatment of advanced acid reflux.
4
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INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
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2023
|
vol. 28
111-118
EN
The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.
5
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THE EFFECT OF A HYDROPHILIZING SUBSTANCE ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
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2011
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vol. 16
105 - 110
EN
Commonly applied drug forms tend to leave the vagina when the patient assumes an upright position. Permanent contact of the drug form with the vaginal mucosa during daily activities of the patient is an indispensable condition for 24-hour therapy. This condition may be fulfilled by drug forms with high ability to adhere to vaginal mucosa. The investigations demonstrated that the thermosensitive polymer - poloxamer 407 increases significantly the adhesive properties of hydrophilic gels, but at the same time it increases their pH. The use of pectin resulted in a decrease of the pH. The addition of glycerol or 1,2-propylene glycol caused further decrease of the pH. Rheological investigations demonstrated positive pharmaceutical properties of the investigated preparations. The obtained parameters gels should provide positive application effects. The investigations revealed that it is possible to obtain gels with high adhesion properties to vaginal mucous membrane.
6
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INFLUENCE OF PECTIN AND CHITOSAN ON THE PROPERTIES OF GELS PROTECTING THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
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2021
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vol. 26
162-169
EN
Among the diseases of the digestive tract, gastro-oesophageal reflux is one of the most troublesome ailments. It is estimated that in highly developed countries, reflux symptoms occur in about 5%-10% of people every day. It has also been found that about 20% of people experience such symptoms once a week. The incidence of this disease increases with age, regardless of gender. The aim of the study was to investigate the physicochemical properties of gels intended for the protection of the oesophageal mucosa. Preparations containing 3.0% pectin showed the lowest pH. These gels can be used in the treatment of advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of pectin concentration on the adhesion work of the tested gels.
7
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CHITOSAN GELS TO PREVENT REFLUX DISEASE

100%
Małolepsza-Jarmołowska K.
|
EN
Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.
8
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INCREASING THE EFFECTIVENESS OF CHITOSAN GELS TO PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2023
|
vol. 28
111-118
EN
The troublesome symptoms of gastro-oesophageal reflux disease are a serious health, medical, and social problem for patients. The main problem is gastro-oesophageal acid reflux. In this study, I investigated hydrogels that could prevent the destruction of the oesophageal mucosa. I investigated the effect of chitosan and poloxamer 407 on the protective properties of gels. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity. Preparations containing 25% poloxamer 407 showed the highest pH. Texture tests showed the effect of the poloxamer concentration on the adhesion performance of the tested gels. The findings suggest that the gels can be used to treat advanced acid reflux.
9
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INFLUENCE OF CHITOSAN ON THE PROPERTIES OF GELS PROTECTING OF THE ESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2019
|
vol. 24
135 - 144
EN
Gastro-esophageal reflux is a term that defines the reverse flow of acid gastric contents into the esophagus. On the other hand, alkaline reflux occurs in the case when alkaline intestinal contents enter the esophagus. The aim of the study was to examine the pharmaceutical properties of gels for the treatment of gastro-esophageal reflux, covering the mucosa, allowing prolonged contact with the esophageal mucosa. Formulations containing the PVP K-30 showed the lowest pH, which is an important feature and can be used in the treatment of advanced alkaline reflux. Gels containing PVP K-90 and chitosan can be used in the treatment of acid reflux. The addition of chitosan significantly increased the dynamic viscosity of the tested gels. The study of the work of adhesion showed the effect of PVP K-30 and PVP K-90 and their concentration on the value of the work of adhesion. The presented studies have shown that it is possible to obtain gels with high adhesion to the esophageal mucous membrane.
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